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AMR Drug RepurposingSmart Screeningresearch prototype

Diazepam

FDA-approved product (tablet, oral), marketed as Diastat, Diastat Acudial, Diazepam and 6 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Diazepam
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Agitation
  • Anxiety
  • Anxiety disorder
  • Cerebral palsy
  • Epilepsy
  • Stiff-Person syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine derivatives
FDA pharmacologic class
Benzodiazepine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli27.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Diazepam in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Diazepam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Association of Different Doses of Clonidine in Caudal Epidural Anesthesia for Hypospadias Surgery

    NCT02769390 · start 2015-07

    Registered record
    Registry ID
    NCT02769390
    Conditions
    Postoperative Pain
    Interventions
    Clonidine 1 mcg/Kg; Clonidine 2 mcg/ Kg; Clonidine 3 mcg/ Kg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-07
    Completion
    2015-11
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionClonidine 1 mcg/Kg; Clonidine 2 mcg/ Kg; Clonidine 3 mcg/ Kg
    PhasePhase 2
    Registry statusCompleted

  • Diazepam Use With Standard Management for Acute Low Back Pain

    NCT02646124 · start 2015-06

    Registered record
    Registry ID
    NCT02646124
    Conditions
    Low Back Pain
    Interventions
    Naproxen; Placebo; Diazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2015-06
    Completion
    2016-05
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain
    InterventionNaproxen; Placebo; Diazepam
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Diazepam at the Active Phase of Labor

    NCT02232035 · start 2014-09

    Registered record
    Registry ID
    NCT02232035
    Conditions
    Pain; Prolonged Labour
    Interventions
    normal saline/diazepam at the active phase of labor
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2014-09
    Completion
    2015-09
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Prolonged Labour
    Interventionnormal saline/diazepam at the active phase of labor
    PhasePhase 2
    Registry statusUnknown

  • A Workflow and Satisfaction Study Evaluating the Implementation of a New "Smart" Ambulatory Infusion System

    NCT01997099 · start 2013-11

    Registered record
    Registry ID
    NCT01997099
    Conditions
    Home Healthcare Organizations Utilizing Ambulatory Infusion Pumps; Patients Requiring Infusion With an Ambulatory Infusion Pump
    Interventions
    CADD®-Solis VIP Pump; CADD™ Solis Medication Safety Software Administrator
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-11
    Completion
    2015-10
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHome Healthcare Organizations Utilizing Ambulatory Infusion Pumps; Patients Requiring Infusion With an Ambulatory Infusion Pump
    InterventionCADD®-Solis VIP Pump; CADD™ Solis Medication Safety Software Administrator
    PhaseNot recorded
    Registry statusCompleted

  • Treatment of Alcohol Withdrawal Syndrome With Alpha-2 Agonists and/or Anticonvulsants

    NCT05438641 · start 2013-08

    Registered record
    Registry ID
    NCT05438641
    Conditions
    Alcohol Withdrawal Syndrome
    Interventions
    BZDP-Sparing Protocol; BZDP-Based Protocol
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-08
    Completion
    2017-08
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Withdrawal Syndrome
    InterventionBZDP-Sparing Protocol; BZDP-Based Protocol
    PhaseNot recorded
    Registry statusCompleted

  • Gabapentin Treatment of Benzodiazepine Dependence

    NCT01893632 · start 2013-07

    Registered record
    Registry ID
    NCT01893632
    Conditions
    Benzodiazepine Dependence
    Interventions
    gabapentin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-07
    Completion
    2016-04-01
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenzodiazepine Dependence
    Interventiongabapentin; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Prevention of Posttraumatic Stress Disorder (PTSD) With Diazepam

    NCT01221883 · start 2013-05

    Registered record
    Registry ID
    NCT01221883
    Conditions
    Posttraumatic Stress Disorder
    Interventions
    Diazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-05
    Completion
    2014-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPosttraumatic Stress Disorder
    InterventionDiazepam
    PhasePhase 4
    Registry statusUnknown

  • A Pilot Study Examining the Efficacy of Biomodulator Treatment for Chronic Low Back Pain

    NCT02707094 · start 2013-01

    Registered record
    Registry ID
    NCT02707094
    Conditions
    Chronic Low Back Pain
    Interventions
    Biomodulator; Usual Care (Medication + Exercise)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-01
    Completion
    2016-08-31
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Low Back Pain
    InterventionBiomodulator; Usual Care (Medication + Exercise)
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy Study of Δ9-THC to Treat Chronic Abdominal Pain

    NCT01318369 · start 2011-10

    Registered record
    Registry ID
    NCT01318369
    Conditions
    Cannabinoid; Tetrahydrocannabinol; Chronic Pancreatitis; Abdominal Pain
    Interventions
    Namisol; Diazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-10
    Completion
    2013-05
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCannabinoid; Tetrahydrocannabinol; Chronic Pancreatitis; Abdominal Pain
    InterventionNamisol; Diazepam
    PhasePhase 2
    Registry statusCompleted

  • Comparative Study of Hemodynamic Changes Caused by Diazepam and Midazolam During Third Molar Surgery

    NCT02177955 · start 2011-01

    Registered record
    Registry ID
    NCT02177955
    Conditions
    Anxiety
    Interventions
    7.5 mg Midazolam; 10 mg diazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-01
    Completion
    2012-09
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety
    Intervention7.5 mg Midazolam; 10 mg diazepam
    PhasePhase 4
    Registry statusCompleted

  • Therapeutic Effect of Quetiapine on Methamphetamine-Induced Psychosis

    NCT01939093 · start 2010-03

    Registered record
    Registry ID
    NCT01939093
    Conditions
    Methamphetamine-induced Psychosis
    Interventions
    Diazepam; Vitamin B1-6-12; Stugeron
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-03
    Completion
    2011-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethamphetamine-induced Psychosis
    InterventionDiazepam; Vitamin B1-6-12; Stugeron
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Hair Transplantation Compared With Hypodermic Needle Irritation in Alopecia Areata

    NCT01385839 · start 2009-10

    Registered record
    Registry ID
    NCT01385839
    Conditions
    Alopecia Areata; Alopecia; Balding
    Interventions
    Hair transplantation; Hypodermic needle irritation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2009-10
    Completion
    2012-05
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia Areata; Alopecia; Balding
    InterventionHair transplantation; Hypodermic needle irritation
    PhaseNot applicable
    Registry statusTerminated

  • Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2)

    NCT00621478 · start 2008-02

    Registered record
    Registry ID
    NCT00621478
    Conditions
    Status Epilepticus
    Interventions
    lorazepam or diazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2008-02
    Completion
    2012-05
    Enrolment
    259

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStatus Epilepticus
    Interventionlorazepam or diazepam
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Effects of Discontinuation of Benzodiazepine-derivative Hypnotics on Cognitive and Motor Functions in Elderly Persons

    NCT00707915 · start 2008-01

    Registered record
    Registry ID
    NCT00707915
    Conditions
    Adverse Effects
    Interventions
    Drug: Benzodiazepine (listed out below)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-01
    Completion
    2010-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdverse Effects
    InterventionDrug: Benzodiazepine (listed out below)
    PhasePhase 4
    Registry statusCompleted

  • Exploring the Effects of Diazepam and Lorazepam

    NCT00696033 · start 2007-07

    Registered record
    Registry ID
    NCT00696033
    Conditions
    Healthy Subjects
    Interventions
    Diazepam; Lorazepam; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-07
    Completion
    2008-12
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Subjects
    InterventionDiazepam; Lorazepam; placebo
    PhaseNot applicable
    Registry statusCompleted