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AMR Drug RepurposingSmart Screeningresearch prototype

Sodium Gluconate

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Sodium Gluconate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

Anti-infective classification
Neither a WHO ATC code nor an FDA pharmacologic class was found for it, so whether it is already an antimicrobial is not established. It needs review and is not counted as a repurposing candidate.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Sodium Gluconate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA10.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli23.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis18.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sodium Gluconate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sodium Gluconate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Baseline Oral Health Study: UnCoVer the Connections to General Health

    NCT04954313 · start 2021-09-28

    Registered record
    Registry ID
    NCT04954313
    Conditions
    Cardiovascular Diseases; Diabetes Type 2
    Interventions
    Subgingival chlorhexidine irrigation; Dental Supplies; Periodonal Treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-09-28
    Completion
    2025-02-01
    Enrolment
    786

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Diseases; Diabetes Type 2
    InterventionSubgingival chlorhexidine irrigation; Dental Supplies; Periodonal Treatment
    PhasePhase 4
    Registry statusCompleted

  • Ultrasound Guided Steroids Injection Versus PRP for Shoulder Pain Relief

    NCT05317624 · start 2021-08-10

    Registered record
    Registry ID
    NCT05317624
    Conditions
    Shoulder Pain
    Interventions
    Platelet rich plasma; Methylprednisolone
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2021-08-10
    Completion
    2023-02-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShoulder Pain
    InterventionPlatelet rich plasma; Methylprednisolone
    PhaseEarly phase 1
    Registry statusCompleted

  • Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma

    NCT04521335 · start 2021-05-21

    Registered record
    Registry ID
    NCT04521335
    Conditions
    Multiple Myeloma
    Interventions
    Disulfiram; Copper Gluconate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2021-05-21
    Completion
    2022-02-06
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Myeloma
    InterventionDisulfiram; Copper Gluconate
    PhasePhase 1
    Registry statusTerminated

  • Vitamin D and Zinc Supplementation for Improving Treatment Outcomes Among COVID-19 Patients in India

    NCT04641195 · start 2021-04-22

    Registered record
    Registry ID
    NCT04641195
    Conditions
    COVID-19
    Interventions
    Vitamin D3 (cholecalciferol); Zinc (zinc gluconate); Zinc (zinc gluconate) & Vitamin D (cholecalciferol); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-04-22
    Completion
    2022-08-01
    Enrolment
    181

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19
    InterventionVitamin D3 (cholecalciferol); Zinc (zinc gluconate); Zinc (zinc gluconate) & Vitamin D (cholecalciferol); Placebo
    PhasePhase 3
    Registry statusCompleted

  • Chlorhexidine Mouthrinse Before EBUS-TBNA

    NCT04718922 · start 2021-01-20

    Registered record
    Registry ID
    NCT04718922
    Conditions
    Endobronchial Ultrasound
    Interventions
    Chlorhexidine Gluconate 0.12 % Mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-01-20
    Completion
    2021-12-11
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndobronchial Ultrasound
    InterventionChlorhexidine Gluconate 0.12 % Mouthwash
    PhasePhase 4
    Registry statusCompleted

  • Mouth Rinses for Inactivation of COVID-19

    NCT04584684 · start 2020-12-18

    Registered record
    Registry ID
    NCT04584684
    Conditions
    Covid19; Coronavirus Infection; SARS-CoV-2 Infection
    Interventions
    0.9% w/v NaCL Saline; 1.5% w/v Hydrogen Peroxide; 0.12% Chlorohexidine Gluconate; 27% Ethanol plus essential oils; 0.5% w/v Povidone-iodide; 0.075% Cetylpyridinium Chloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2020-12-18
    Completion
    2021-10-21
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCovid19; Coronavirus Infection; SARS-CoV-2 Infection
    Intervention0.9% w/v NaCL Saline; 1.5% w/v Hydrogen Peroxide; 0.12% Chlorohexidine Gluconate; 27% Ethanol plus essential oils +2 more
    PhasePhase 2
    Registry statusTerminated

  • Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery

    NCT04256798 · start 2020-11-13

    Registered record
    Registry ID
    NCT04256798
    Conditions
    Infection; Pneumonia; Surgical Site Infection; Wound Infection; Surgical Wound Infection; Postoperative Complications; Anesthesia; Communicable Disease; Pathologic Processes; Perioperative Complication; Chlorhexidine; Laparotomy
    Interventions
    Chlorhexidine mouthwash; Oxygen; Oxygen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2020-11-13
    Completion
    2026-06-01
    Enrolment
    12,942

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Pneumonia; Surgical Site Infection; Wound Infection +8 more
    InterventionChlorhexidine mouthwash; Oxygen; Oxygen
    PhasePhase 3
    Registry statusRecruiting

  • Efficacy of Zinc L-Carnosine Mouth Rinse

    NCT04430998 · start 2020-06

    Registered record
    Registry ID
    NCT04430998
    Conditions
    Periodontal Index; Pain
    Interventions
    Zinc L-Carnosine; Chlorhexidine; Water
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2020-06
    Completion
    2020-06-30
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Index; Pain
    InterventionZinc L-Carnosine; Chlorhexidine; Water
    PhasePhase 3
    Registry statusUnknown

  • Ultrasound Guided Peripheral Intravenous Catheterization in the Pediatric Intensive Care Unit.

    NCT04268225 · start 2020-03

    Registered record
    Registry ID
    NCT04268225
    Conditions
    Peripheral Venous Cannulation
    Interventions
    US guided dynamic needle tip positioning peripheral intravenous cannulation; Traditional peripheral intravenous cannulation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-03
    Completion
    2022-03
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeripheral Venous Cannulation
    InterventionUS guided dynamic needle tip positioning peripheral intravenous cannulation; Traditional peripheral intravenous cannulation
    PhaseNot applicable
    Registry statusUnknown

  • Oral Care in Non-Mechanically Ventilated Stroke Patients

    NCT05521659 · start 2020-01-01

    Registered record
    Registry ID
    NCT05521659
    Conditions
    Stroke, Ischemic
    Interventions
    Standardized oral care protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-01-01
    Completion
    2020-06-30
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStroke, Ischemic
    InterventionStandardized oral care protocol
    PhaseNot applicable
    Registry statusCompleted

  • Is Therapeutic Elastic Bandage As Effective As Corticosteroids Following Third Molar Surgery?

    NCT04200885 · start 2019-05-02

    Registered record
    Registry ID
    NCT04200885
    Conditions
    Third Molar Surgery
    Interventions
    Dexketoprofen Trometamol; Dexamethasone 21-Phosphate; Therapeutic Elastic Bandage
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-05-02
    Completion
    2019-11-21
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThird Molar Surgery
    InterventionDexketoprofen Trometamol; Dexamethasone 21-Phosphate; Therapeutic Elastic Bandage
    PhasePhase 4
    Registry statusCompleted

  • BPO vs Hibiclens Soap for Surgical Preparation

    NCT04021524 · start 2018-09-10

    Registered record
    Registry ID
    NCT04021524
    Conditions
    Propionibacterium Acnes
    Interventions
    Benzoyl Peroxide 10% Bar; Chlorhexidine Gluconate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-09-10
    Completion
    2021-04-16
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPropionibacterium Acnes
    InterventionBenzoyl Peroxide 10% Bar; Chlorhexidine Gluconate
    PhasePhase 4
    Registry statusCompleted

  • Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme

    NCT03363659 · start 2018-03-28

    Registered record
    Registry ID
    NCT03363659
    Conditions
    Glioblastoma; Glioblastoma Multiforme
    Interventions
    Disulfiram; Copper gluconate; Temozolomide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2018-03-28
    Completion
    2022-01-13
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlioblastoma; Glioblastoma Multiforme
    InterventionDisulfiram; Copper gluconate; Temozolomide
    PhasePhase 2
    Registry statusTerminated

  • Clinical Evaluation of a Mouthwash Containing Malva Sylvestris Extract.

    NCT05138484 · start 2017-10-20

    Registered record
    Registry ID
    NCT05138484
    Conditions
    Periodontal Diseases
    Interventions
    experimental group 10% mouthwash of M. sylvestris extract
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-10-20
    Completion
    2019-01-14
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Diseases
    Interventionexperimental group 10% mouthwash of M. sylvestris extract
    PhasePhase 3
    Registry statusCompleted

  • Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)

    NCT02997020 · start 2017-05-18

    Registered record
    Registry ID
    NCT02997020
    Conditions
    CRS
    Interventions
    EDSPD
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2017-05-18
    Completion
    2027-05-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCRS
    InterventionEDSPD
    PhaseNot recorded
    Registry statusActive not recruiting