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AMR Drug RepurposingSmart Screeningresearch prototype

Bacitracin

FDA-approved product (ointment, ophthalmic), marketed as Baci-Rx, Baciguent, Bacitracin and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Bacitracin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Burn
  • Eye infection
  • Infection
  • Inflammation
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antibiotics for topical use; Other antibacterials; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01XX10; WHO ATC D06AX05; WHO ATC R02AB04; WHO ATC S01AA32

Repurposing investigation

Bacitracin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA82.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. A stereoisomer of this medicine was in the model's training data.
  • E. coli65.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae49.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Bacitracin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Bacitracin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Nailbed Repair for Patients With Nailbed Injuries

    NCT07388823 · start 2026-06-01

    Registered record
    Registry ID
    NCT07388823
    Conditions
    Nail Bed Injury; Nail Laceration; Nail Plate Disruption
    Interventions
    Nail Bed Repair; Nail bed dressing
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-06-01
    Completion
    2030-10-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNail Bed Injury; Nail Laceration; Nail Plate Disruption
    InterventionNail Bed Repair; Nail bed dressing
    PhaseNot applicable
    Registry statusRecruiting

  • Sebum Metabolomics and Lipidomics for Clinical Applications

    NCT07549828 · start 2026-04-01

    Registered record
    Registry ID
    NCT07549828
    Conditions
    Acne; Atopic Dermatitis; Seborrheic Dermatitis; Psoriasis; Healthy Subjects (HS)
    Interventions
    Sebutape sampling; Bacitracin/Polymyxin B/Neomycin ointment (Yentuogin ointment)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-04-01
    Completion
    2029-03-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne; Atopic Dermatitis; Seborrheic Dermatitis; Psoriasis +1 more
    InterventionSebutape sampling; Bacitracin/Polymyxin B/Neomycin ointment (Yentuogin ointment)
    PhaseNot applicable
    Registry statusNot yet recruiting

  • The Safety and Microbial Changes in the Use of Intranasal Neosporin®

    NCT07698938 · start 2025-02-13

    Registered record
    Registry ID
    NCT07698938
    Conditions
    Teste the Safety of (Polymyxin B Sulfate 500,000 IU, Bacitracin Zinc 40,000 IU, Neomycin Sulfate 0.35g Neomycin Base) Intranasally
    Interventions
    Intranasal application of Polymyxin B Sulfate 500,000 IU, Bacitracin zinc 40,000 IU, Neomycin Sulfate 0.35g neomycin base
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-02-13
    Completion
    2025-03-23
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTeste the Safety of (Polymyxin B Sulfate 500,000 IU, Bacitracin Zinc 40,000 IU, Neomycin Sulfate 0.35g Neomycin Base) Intranasally
    InterventionIntranasal application of Polymyxin B Sulfate 500,000 IU, Bacitracin zinc 40,000 IU, Neomycin Sulfate 0.35g neomycin base
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Assessment of Protopic® Ointment in Deep Partial-Thickness Burns

    NCT05856994 · start 2024-09-19

    Registered record
    Registry ID
    NCT05856994
    Conditions
    Burn Injury
    Interventions
    Tacrolimus ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2024-09-19
    Completion
    2026-04-20
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurn Injury
    InterventionTacrolimus ointment
    PhasePhase 1
    Registry statusTerminated

  • Topical Phenytoin-Loaded Hydrogel Dressing for Postoperative Wound Management After Oral Squamous Cell Carcinoma Resection

    NCT07801157 · start 2024-07-01

    Registered record
    Registry ID
    NCT07801157
    Conditions
    Postoperative Wound Healing After Oral Cancer Surgery
    Interventions
    Topical Phenytoin-Loaded Hydrogel Dressing; Conventional Postoperative Wound Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-07-01
    Completion
    2025-12-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Wound Healing After Oral Cancer Surgery
    InterventionTopical Phenytoin-Loaded Hydrogel Dressing; Conventional Postoperative Wound Care
    PhaseNot applicable
    Registry statusCompleted

  • Chronic Suppurative Otitis Media Microbiology

    NCT06424704 · start 2024-05-15

    Registered record
    Registry ID
    NCT06424704
    Conditions
    Otitis Media, Suppurative Chronic; Cholesteatoma; Microbial Colonization
    Interventions
    Microbiological culture
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-05-15
    Completion
    2026-05
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOtitis Media, Suppurative Chronic; Cholesteatoma; Microbial Colonization
    InterventionMicrobiological culture
    PhaseNot recorded
    Registry statusUnknown

  • Comparing CO2 Laser and Electrosurgical Treatments for Perianal Condyloma

    NCT06166290 · start 2024-01

    Registered record
    Registry ID
    NCT06166290
    Conditions
    Perianal Wart
    Interventions
    CO2 LASER Vaporisation; Electrosurgical Fulguration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-01
    Completion
    2026-04
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerianal Wart
    InterventionCO2 LASER Vaporisation; Electrosurgical Fulguration
    PhaseNot applicable
    Registry statusUnknown

  • Mupirocin 2% Ointment Vs Spray Antibiotics on Temporary Hemodialysis Catheter

    NCT05874219 · start 2023-04-10

    Registered record
    Registry ID
    NCT05874219
    Conditions
    Hemodialysis Complication; Hemodialysis Catheter Infection
    Interventions
    Local antibiotic spray Neomycin sulphate 165,000 IU + Bacitracin zinc 12,500 IU; Mupirocin 2% ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2023-04-10
    Completion
    2023-05-25
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodialysis Complication; Hemodialysis Catheter Infection
    InterventionLocal antibiotic spray Neomycin sulphate 165,000 IU + Bacitracin zinc 12,500 IU; Mupirocin 2% ointment
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Topical Antibacterial Agents for Prevention of COVID-19

    NCT05449392 · start 2022-09-01

    Registered record
    Registry ID
    NCT05449392
    Conditions
    COVID-19; SARS-CoV2 Infection
    Interventions
    Neosporin; Vaseline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2022-09-01
    Completion
    2023-09-22
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19; SARS-CoV2 Infection
    InterventionNeosporin; Vaseline
    PhasePhase 1
    Registry statusCompleted

  • Processed Amniotic Fluid (pAF) for the Treatment of Chronic Wounds

    NCT04438174 · start 2022-08

    Registered record
    Registry ID
    NCT04438174
    Conditions
    Wounds and Injuries
    Interventions
    Processed Amniotic Fluid; Standard of Care Wound Treatment Regimen
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2022-08
    Completion
    2023-03
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWounds and Injuries
    InterventionProcessed Amniotic Fluid; Standard of Care Wound Treatment Regimen
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • Impaired Risk Awareness During Intoxication in DUI Offenders

    NCT05247788 · start 2022-02-02

    Registered record
    Registry ID
    NCT05247788
    Conditions
    Alcohol Use
    Interventions
    Blood alcohol concentration (BAC) discrimination training; Performance feedback training; Blood alcohol concentration (BAC) discrimination training for controls
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-02-02
    Completion
    2025-03-01
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Use
    InterventionBlood alcohol concentration (BAC) discrimination training; Performance feedback training; Blood alcohol concentration (BAC) discrimination training for controls
    PhaseNot applicable
    Registry statusCompleted

  • The Effects of Post-Operative Interventions on Surgical Site Occurrences in AWR

    NCT04906408 · start 2021-09-17

    Registered record
    Registry ID
    NCT04906408
    Conditions
    Abdomen Hernia
    Interventions
    Prevena; Prineo; Traditional
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2021-09-17
    Completion
    2028-05-01
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdomen Hernia
    InterventionPrevena; Prineo; Traditional
    PhaseNot applicable
    Registry statusRecruiting

  • A Randomized Trial Evaluating EARLY Application of a Surfactant Dressing in Thermal Injury (EARLY)

    NCT04880655 · start 2021-08-03

    Registered record
    Registry ID
    NCT04880655
    Conditions
    Burns; Partial-thickness Burn
    Interventions
    WSD; Dressed with bacitracin and petrolatum gauze
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-08-03
    Completion
    2023-10-24
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns; Partial-thickness Burn
    InterventionWSD; Dressed with bacitracin and petrolatum gauze
    PhaseNot applicable
    Registry statusCompleted

  • Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty

    NCT04075526 · start 2019-10-01

    Registered record
    Registry ID
    NCT04075526
    Conditions
    Osteoarthritis
    Interventions
    Povidone iodine; Vancomycin powder; Conventional
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-10-01
    Completion
    2025-12-13
    Enrolment
    2,129

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionPovidone iodine; Vancomycin powder; Conventional
    PhasePhase 1
    Registry statusCompleted

  • Prospective Randomized Clinical Trial on Oral and Intravenous Antibiotic Prophylaxis in Colorectal Surgery.

    NCT04438655 · start 2019-05-01

    Registered record
    Registry ID
    NCT04438655
    Conditions
    Colorectal Surgery
    Interventions
    Oral antibiotic drugs; Parenteral prophylaxis
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-05-01
    Completion
    2021-11-01
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Surgery
    InterventionOral antibiotic drugs; Parenteral prophylaxis
    PhaseNot applicable
    Registry statusCompleted