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AMR Drug RepurposingSmart Screeningresearch prototype

Midazolam

FDA-approved product (spray, nasal), marketed as Midazolam In 0.8% Sodium Chloride, Midazolam In 0.9% Sodium Chloride, Nayzilam and 6 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Midazolam
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Amnesia
  • Epilepsy
  • Seizure
  • Status epilepticus

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine derivatives
FDA pharmacologic class
Benzodiazepine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis64.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Midazolam in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Midazolam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Analgesic Effects of Midazolam in Human Volunteers

    NCT02629146 · start 2015-12

    Registered record
    Registry ID
    NCT02629146
    Conditions
    Analgesic Drugs; Antinociceptive Agents
    Interventions
    Midazolam; Fentanyl; Isotonic saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-12
    Completion
    2016-03
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnalgesic Drugs; Antinociceptive Agents
    InterventionMidazolam; Fentanyl; Isotonic saline
    PhasePhase 4
    Registry statusCompleted

  • Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD)

    NCT02647086 · start 2015-12

    Registered record
    Registry ID
    NCT02647086
    Conditions
    Atopic Dermatitis
    Interventions
    Dupilumab; Midazolam; Omeprazole; Warfarin; Caffeine; Metoprolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-12
    Completion
    2016-07
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtopic Dermatitis
    InterventionDupilumab; Midazolam; Omeprazole; Warfarin +2 more
    PhasePhase 1
    Registry statusCompleted

  • Dabigatran in an Interaction Probe Drug Cocktail

    NCT02361619 · start 2015-02

    Registered record
    Registry ID
    NCT02361619
    Conditions
    Healthy Volunteers
    Interventions
    Caffeine; Diclofenac; Esomeprazole; Metoprolol; Midazolam; Dabigatran; Clarithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-02
    Completion
    2017-06
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionCaffeine; Diclofenac; Esomeprazole; Metoprolol +3 more
    PhasePhase 1
    Registry statusCompleted

  • Pilot Study on Pairing Sedation Strategies and Weaning

    NCT02219659 · start 2014-12

    Registered record
    Registry ID
    NCT02219659
    Conditions
    Acute Respiratory Failure
    Interventions
    Sedation Protocol with Daily Interruption; Sedation Protocol Without Daily Interruption; Fentanyl Push First
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-12
    Completion
    2018-05-18
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Respiratory Failure
    InterventionSedation Protocol with Daily Interruption; Sedation Protocol Without Daily Interruption; Fentanyl Push First
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration

    NCT02396537 · start 2014-01

    Registered record
    Registry ID
    NCT02396537
    Conditions
    Pain
    Interventions
    Lidocaine; Midazolam; 0.9% Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-01
    Completion
    2014-08
    Enrolment
    77

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionLidocaine; Midazolam; 0.9% Saline
    PhaseNot applicable
    Registry statusCompleted

  • Patient Satisfaction With Propofol for Out Patient Colonoscopy

    NCT02937506 · start 2013-11

    Registered record
    Registry ID
    NCT02937506
    Conditions
    Colon Cancer; IBS; Polyps
    Interventions
    Propofol; Fentanyl Plus Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-11
    Completion
    2016-08
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColon Cancer; IBS; Polyps
    InterventionPropofol; Fentanyl Plus Midazolam
    PhasePhase 4
    Registry statusCompleted

  • Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children

    NCT02013986 · start 2013-09

    Registered record
    Registry ID
    NCT02013986
    Conditions
    Congenital Hydronephrosis; Congenital Choledochal Cyst; Fracture
    Interventions
    etomidate; midazolam; propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-09
    Completion
    2014-08
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCongenital Hydronephrosis; Congenital Choledochal Cyst; Fracture
    Interventionetomidate; midazolam; propofol
    PhasePhase 4
    Registry statusUnknown

  • Sevoflurane- Safety in Long-term Sedation Procedures

    NCT01802255 · start 2013-03

    Registered record
    Registry ID
    NCT01802255
    Conditions
    Poisoning by Inhaled Anaesthetic; Fluoride Poisoning; Recovery From Sedation; Renal Function; Hepatic Function
    Interventions
    Sevoflurane; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2013-03
    Completion
    2015-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPoisoning by Inhaled Anaesthetic; Fluoride Poisoning; Recovery From Sedation; Renal Function +1 more
    InterventionSevoflurane; Midazolam
    PhasePhase 3
    Registry statusWithdrawn

  • Performance of Endoscopic Submucosal Dissection According to the Sedation Method

    NCT01806753 · start 2013-03

    Registered record
    Registry ID
    NCT01806753
    Conditions
    Early Gastric Cancer; Gastric Adenoma
    Interventions
    Intermittent midazolam/propofol injection controlled by endoscopist; Continuous propofol infusion with opioid administration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-03
    Completion
    2014-01
    Enrolment
    157

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEarly Gastric Cancer; Gastric Adenoma
    InterventionIntermittent midazolam/propofol injection controlled by endoscopist; Continuous propofol infusion with opioid administration
    PhaseNot applicable
    Registry statusCompleted

  • Study to Evaluate the Long-term Safety and Tolerability of USL261 in Patients With Seizure Clusters

    NCT01529034 · start 2012-07

    Registered record
    Registry ID
    NCT01529034
    Conditions
    Epilepsy
    Interventions
    USL261
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2012-07
    Completion
    Not recorded
    Enrolment
    175

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionUSL261
    PhasePhase 3
    Registry statusTerminated

  • Dexmedetomidine Premedication in Hypertensive Patients

    NCT02058485 · start 2012-01

    Registered record
    Registry ID
    NCT02058485
    Conditions
    Hypertension
    Interventions
    Midazolam; Dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-01
    Completion
    2013-06
    Enrolment
    162

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionMidazolam; Dexmedetomidine
    PhasePhase 3
    Registry statusCompleted

  • Safety Evaluation of Dexmedetomidine for EBUS-TBNA

    NCT01381627 · start 2011-06

    Registered record
    Registry ID
    NCT01381627
    Conditions
    Lung Cancer
    Interventions
    Remifentanil; Dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-06
    Completion
    2013-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Cancer
    InterventionRemifentanil; Dexmedetomidine
    PhasePhase 4
    Registry statusUnknown

  • Study of Comparison of the Effectiveness of Three Diagrams for Sedation in Spinal Anesthesia

    NCT02136641 · start 2011-06

    Registered record
    Registry ID
    NCT02136641
    Conditions
    Anesthesia; Reaction
    Interventions
    Midazolam; Midazolam+Fentanyl Combination; Midazolam+Ketamine Combination
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-06
    Completion
    2012-06
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Reaction
    InterventionMidazolam; Midazolam+Fentanyl Combination; Midazolam+Ketamine Combination
    PhasePhase 4
    Registry statusCompleted

  • The Effects of Denosumab on the Pharmacokinetics (PK) of Midazolam

    NCT01221727 · start 2010-11

    Registered record
    Registry ID
    NCT01221727
    Conditions
    Postmenopausal Osteoporosis
    Interventions
    Denosumab; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-11
    Completion
    2011-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostmenopausal Osteoporosis
    InterventionDenosumab; Midazolam
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers

    NCT01162486 · start 2010-04

    Registered record
    Registry ID
    NCT01162486
    Conditions
    Tuberculosis; Tuberculosis, Pulmonary
    Interventions
    Rifampin & midazolam; rifapentine & midazolam; rifapentine & midazolam; rifapentine & midazolam; rifapentine and midazolam; rifapentine and midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-04
    Completion
    2011-03
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Tuberculosis, Pulmonary
    InterventionRifampin & midazolam; rifapentine & midazolam; rifapentine & midazolam; rifapentine & midazolam +2 more
    PhasePhase 1
    Registry statusCompleted