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AMR Drug RepurposingSmart Screeningresearch prototype

Oxytocin

FDA-approved product (solution, nasal), marketed as Oxytocin, Oxytocin 10 Usp Units In Dextrose 5%, Oxytocin 20 Usp Units In Dextrose 5% and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Oxytocin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage
  • Uterine Inertia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Oxytocin and analogues
FDA pharmacologic class
Oxytocic FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA74.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae52.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Oxytocin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Oxytocin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Trial for Acupuncture in Adolescents With Psychological Distress and Insomnia

    NCT06638450 · start 2026-08-18

    Registered record
    Registry ID
    NCT06638450
    Conditions
    Psychological Distress; Insomnia
    Interventions
    Dense Cranial Electroacupuncture Stimulation plus Body Acupuncture (DCEAS+BA); Minimal Acupuncture Stimulation (MAS)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-08-18
    Completion
    2028-09
    Enrolment
    148

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsychological Distress; Insomnia
    InterventionDense Cranial Electroacupuncture Stimulation plus Body Acupuncture (DCEAS+BA); Minimal Acupuncture Stimulation (MAS)
    PhaseNot applicable
    Registry statusRecruiting

  • Carbetocin vs Misoprostol for Postpartum Hemorrhage Prevention

    NCT07353281 · start 2026-01-31

    Registered record
    Registry ID
    NCT07353281
    Conditions
    Postpartum Complication; Postpartum Hemorrhage
    Interventions
    Carbetocin 100 Microgram/mL Solution for Injection; Misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-01-31
    Completion
    2028-01-01
    Enrolment
    146

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Complication; Postpartum Hemorrhage
    InterventionCarbetocin 100 Microgram/mL Solution for Injection; Misoprostol
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Oxytocin's Effects on Emotional Processing and Its Acting Routes

    NCT07425938 · start 2026-01-24

    Registered record
    Registry ID
    NCT07425938
    Conditions
    Healthy Adult Male
    Interventions
    placebo (compared to vasoconstrictor); vasoconstrictor (Otrivin); placebo (compared to oxytocin); oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-01-24
    Completion
    2026-04-15
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Adult Male
    Interventionplacebo (compared to vasoconstrictor); vasoconstrictor (Otrivin); placebo (compared to oxytocin); oxytocin
    PhaseNot applicable
    Registry statusRecruiting

  • Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain

    NCT07053774 · start 2025-11-05

    Registered record
    Registry ID
    NCT07053774
    Conditions
    Pain, Acute
    Interventions
    Intravenous oxytocin; Intravenous placebo; Intranasal oxytocin; Intranasal placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2025-11-05
    Completion
    2026-06-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Acute
    InterventionIntravenous oxytocin; Intravenous placebo; Intranasal oxytocin; Intranasal placebo
    PhasePhase 2
    Registry statusCompleted

  • Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section

    NCT07188207 · start 2025-10-01

    Registered record
    Registry ID
    NCT07188207
    Conditions
    Postpartum Hemorrhage
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-10-01
    Completion
    2026-12-31
    Enrolment
    282

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Hemorrhage
    InterventionOxytocin
    PhaseNot applicable
    Registry statusNot yet recruiting

  • The Effect of Music That the Individuals With Moderate Dental Anxiety Have Started Listening to While Waiting

    NCT07274501 · start 2025-04-17

    Registered record
    Registry ID
    NCT07274501
    Conditions
    Dental Anxiety
    Interventions
    Music listening in the waiting room
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-04-17
    Completion
    2026-04-20
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Anxiety
    InterventionMusic listening in the waiting room
    PhaseNot applicable
    Registry statusCompleted

  • Oxytocin Pharmacokinetics and Pharmacodynamics

    NCT05488457 · start 2025-01-01

    Registered record
    Registry ID
    NCT05488457
    Conditions
    Post Partum Hemorrhage; Cesarean Section Complications; Blood Loss
    Interventions
    deuterated oxytocin (d5OT)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2025-01-01
    Completion
    2027-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Partum Hemorrhage; Cesarean Section Complications; Blood Loss
    Interventiondeuterated oxytocin (d5OT)
    PhasePhase 2
    Registry statusRecruiting

  • Effects of Carbetocin and Oxytocin Used in Cesarean Sections on Postoperative Pain

    NCT06692621 · start 2024-10-04

    Registered record
    Registry ID
    NCT06692621
    Conditions
    PREG1
    Interventions
    Oxytocin; Carbetocin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2024-10-04
    Completion
    2025-01-10
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPREG1
    InterventionOxytocin; Carbetocin
    PhaseNot recorded
    Registry statusCompleted

  • Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery

    NCT06970483 · start 2023-12-01

    Registered record
    Registry ID
    NCT06970483
    Conditions
    Postpartum Hemorrhage; Cesarean Section Complications; Delivery Complication
    Interventions
    Tranexamic acid; Misoprostol 200mcg Tab
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-12-01
    Completion
    2024-12-01
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Hemorrhage; Cesarean Section Complications; Delivery Complication
    InterventionTranexamic acid; Misoprostol 200mcg Tab
    PhasePhase 4
    Registry statusCompleted

  • Time of Oxytocin Initiation at 2nd Stage of Labor and Adverse Outcomes

    NCT06181396 · start 2023-10-01

    Registered record
    Registry ID
    NCT06181396
    Conditions
    Delivery Complication; Cesarean Delivery Affecting Fetus
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-10-01
    Completion
    2026-10
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDelivery Complication; Cesarean Delivery Affecting Fetus
    InterventionOxytocin
    PhaseNot applicable
    Registry statusRecruiting

  • Oxytocin Effects on Bone in Children With Autism Spectrum Disorder

    NCT05754073 · start 2023-08-01

    Registered record
    Registry ID
    NCT05754073
    Conditions
    Autism Spectrum Disorder; Bone Health
    Interventions
    1. Intranasal oxytocin spray; 2. Intranasal placebo spray; 3. Intranasal Oxytocin spray
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2023-08-01
    Completion
    2028-08-31
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutism Spectrum Disorder; Bone Health
    Intervention1. Intranasal oxytocin spray; 2. Intranasal placebo spray; 3. Intranasal Oxytocin spray
    PhasePhase 2
    Registry statusRecruiting

  • After Caesarean Section Oxitocin Breast Massage Anthropometric Characteristics of the Newborn

    NCT06242886 · start 2023-02-20

    Registered record
    Registry ID
    NCT06242886
    Conditions
    Breastfeeding, Exclusive; Breastfeeding
    Interventions
    Oxytocin massage; and Breast massage
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-02-20
    Completion
    2023-09-20
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreastfeeding, Exclusive; Breastfeeding
    InterventionOxytocin massage; and Breast massage
    PhaseNot applicable
    Registry statusCompleted

  • Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain

    NCT05179421 · start 2022-05-09

    Registered record
    Registry ID
    NCT05179421
    Conditions
    Healthy Volunteer Study
    Interventions
    Low dose oxytocin; High dose oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2022-05-09
    Completion
    2023-02-10
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteer Study
    InterventionLow dose oxytocin; High dose oxytocin
    PhasePhase 2
    Registry statusCompleted

  • To Evaluate the Efficacy and Safety of Balloon Catheter Combined With Oxytocin Induction in Nulliparous Women With Estimated Fetal Weight ≥3500g at 39-40 Weeks of Gestation

    NCT05197101 · start 2022-01-17

    Registered record
    Registry ID
    NCT05197101
    Conditions
    Macrosomia, Fetal
    Interventions
    balloon catheter combined with oxytocin induction
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-01-17
    Completion
    2023-03-17
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMacrosomia, Fetal
    Interventionballoon catheter combined with oxytocin induction
    PhaseNot applicable
    Registry statusUnknown

  • The Stimulation To Induce Mothers Study

    NCT05079841 · start 2021-11-15

    Registered record
    Registry ID
    NCT05079841
    Conditions
    Oxytocin; Labor Pain; Induction of Labor Affected Fetus / Newborn; Physiologic Effects of Drugs
    Interventions
    Electric breast pump; Exogenous oxytocin intravenous infusion without nipple stimulation.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2021-11-15
    Completion
    2029-03
    Enrolment
    933

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxytocin; Labor Pain; Induction of Labor Affected Fetus / Newborn; Physiologic Effects of Drugs
    InterventionElectric breast pump; Exogenous oxytocin intravenous infusion without nipple stimulation.
    PhasePhase 4
    Registry statusActive not recruiting