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AMR Drug RepurposingSmart Screeningresearch prototype

Midazolam

FDA-approved product (spray, nasal), marketed as Midazolam In 0.8% Sodium Chloride, Midazolam In 0.9% Sodium Chloride, Nayzilam and 6 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Midazolam
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Amnesia
  • Epilepsy
  • Seizure
  • Status epilepticus

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine derivatives
FDA pharmacologic class
Benzodiazepine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis64.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Midazolam in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Midazolam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Impact of Sedation Practices on Clinical Outcomes Among Mechanically Ventilated Children

    NCT07821268 · start 2026-09-01

    Registered record
    Registry ID
    NCT07821268
    Conditions
    Mechanically Ventilated Children Admitted to the Pediatric Intensive Care Unit
    Interventions
    no need
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2026-09-01
    Completion
    2027-06-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMechanically Ventilated Children Admitted to the Pediatric Intensive Care Unit
    Interventionno need
    PhaseNot recorded
    Registry statusNot yet recruiting

  • A Trial of Lu AH69593 in Healthy Participants

    NCT07775261 · start 2026-08-27

    Registered record
    Registry ID
    NCT07775261
    Conditions
    Healthy Participants
    Interventions
    Lu AH69593; Itraconazole; Carbamazepine; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Not yet recruiting
    Start
    2026-08-27
    Completion
    2026-11-06
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Participants
    InterventionLu AH69593; Itraconazole; Carbamazepine; Midazolam
    PhasePhase 1
    Registry statusNot yet recruiting

  • An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers

    NCT07426757 · start 2026-07-01

    Registered record
    Registry ID
    NCT07426757
    Conditions
    Advanced Malignancies; Advanced Cancer
    Interventions
    PF-07994525; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Recruiting
    Start
    2026-07-01
    Completion
    2030-07-10
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdvanced Malignancies; Advanced Cancer
    InterventionPF-07994525; Midazolam
    PhasePhase 1
    Registry statusRecruiting

  • Comparing Two Doses of Midazolam With Added Dexmedetomidine for Kids Before Surgery

    NCT06979791 · start 2025-06-01

    Registered record
    Registry ID
    NCT06979791
    Conditions
    Preoperative Anxiety Experienced by the Pediatric Patient; Preoperative Anxiety
    Interventions
    Dexmedetomidine + Midazolam 0.4 mg/kg; Dexmedetomidine + Midazolam 0.2 mg/kg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2025-06-01
    Completion
    2026-06-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreoperative Anxiety Experienced by the Pediatric Patient; Preoperative Anxiety
    InterventionDexmedetomidine + Midazolam 0.4 mg/kg; Dexmedetomidine + Midazolam 0.2 mg/kg
    PhasePhase 2
    Registry statusCompleted

  • Midazolam or Fentanyl as Adjuvants to Epidural Bupivacaine Plus Dexamethasone for Analgesia

    NCT06898697 · start 2025-04-01

    Registered record
    Registry ID
    NCT06898697
    Conditions
    Lumbar Spine Fixation
    Interventions
    Epidural fentanyl; epidural midazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-04-01
    Completion
    2025-12-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLumbar Spine Fixation
    InterventionEpidural fentanyl; epidural midazolam
    PhaseNot applicable
    Registry statusCompleted

  • An Open-label, DDI Study to Investigate the Effects of Amlitelimab on the PK of Selected Cytochrome P450 Substrates

    NCT06686628 · start 2024-11-20

    Registered record
    Registry ID
    NCT06686628
    Conditions
    Dermatitis Atopic
    Interventions
    Amlitelimab; Midazolam; Caffeine; Metoprolol; Omeprazole; Warfarin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2024-11-20
    Completion
    2026-04-02
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis Atopic
    InterventionAmlitelimab; Midazolam; Caffeine; Metoprolol +2 more
    PhasePhase 1
    Registry statusCompleted

  • Comparison Between the Effect of Dexmedetomidine _midazolam and ketamine_midazolam Combination

    NCT07074262 · start 2024-10-10

    Registered record
    Registry ID
    NCT07074262
    Conditions
    Postoperative Cognitive Dysfunction; Post Operative Delirium
    Interventions
    Ketamine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-10-10
    Completion
    2025-03-10
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Cognitive Dysfunction; Post Operative Delirium
    InterventionKetamine
    PhaseNot applicable
    Registry statusCompleted

  • Anesthesia and Non-small Cell Lung Cancer Recurrence

    NCT06330038 · start 2024-08-05

    Registered record
    Registry ID
    NCT06330038
    Conditions
    Non-small Cell Lung Cancer; Surgery; Anesthesia
    Interventions
    Propofol; Inhaled anesthetics
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2024-08-05
    Completion
    2028-12-31
    Enrolment
    5,384

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-small Cell Lung Cancer; Surgery; Anesthesia
    InterventionPropofol; Inhaled anesthetics
    PhasePhase 4
    Registry statusRecruiting

  • ECC5004 DDI Study With Atorvastatin, Rosuvastatin, Digoxin and Midazolam in Healthy Participants

    NCT06293742 · start 2024-02-08

    Registered record
    Registry ID
    NCT06293742
    Conditions
    Type 2 Diabetes Mellitus
    Interventions
    ECC5004; Midazolam; Rosuvastatin; Digoxin; Atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2024-02-08
    Completion
    2024-04-15
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 2 Diabetes Mellitus
    InterventionECC5004; Midazolam; Rosuvastatin; Digoxin +1 more
    PhasePhase 1
    Registry statusCompleted

  • A Study to Evaluate the Effects of D-1553 on PK of Midazolam, Caffeine, Rosuvastatin, Furosemide, Digoxin, and Itraconazole or Omeprazole on PK of D-1553

    NCT06105255 · start 2023-05-24

    Registered record
    Registry ID
    NCT06105255
    Conditions
    Healthy Male
    Interventions
    D-1553
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2023-05-24
    Completion
    2024-02-02
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Male
    InterventionD-1553
    PhasePhase 1
    Registry statusCompleted

  • Supraclavicular Block vs Bier's Block for Forearm Trauma Surgery

    NCT07418086 · start 2023-04-01

    Registered record
    Registry ID
    NCT07418086
    Conditions
    Forearm Fractures
    Interventions
    Bier's Block (IVRA); Supraclavicular Block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-04-01
    Completion
    2024-02-01
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionForearm Fractures
    InterventionBier's Block (IVRA); Supraclavicular Block
    PhaseNot applicable
    Registry statusCompleted

  • Impact of Virtual Reality Hypno-sedation on Functional Recovery and Anxiety in Foot Surgery With Regional Anesthesia

    NCT05558449 · start 2022-11-28

    Registered record
    Registry ID
    NCT05558449
    Conditions
    Foot Deformities; Regional Anesthesia Morbidity; Valgus; Hallux; Analgesia
    Interventions
    Hypnosedation; Midazolam injection; Virtual reality
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-11-28
    Completion
    2023-10-16
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFoot Deformities; Regional Anesthesia Morbidity; Valgus; Hallux +1 more
    InterventionHypnosedation; Midazolam injection; Virtual reality
    PhasePhase 4
    Registry statusCompleted

  • A Pharmacokinetic Study to Evaluate the Drug Interaction Between SHR0302 and CYP Substrates in Healthy Volunteers

    NCT05392127 · start 2022-07-15

    Registered record
    Registry ID
    NCT05392127
    Conditions
    Rheumatoid Arthritis
    Interventions
    SHR0302 Tablets; Midazolam Maleate Tablets; Warfarin Sodium Tablets; Omeprazole Enteric Capsules; Vitamin K1 Tablets; Repaglinide Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2022-07-15
    Completion
    2022-08-18
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatoid Arthritis
    InterventionSHR0302 Tablets; Midazolam Maleate Tablets; Warfarin Sodium Tablets; Omeprazole Enteric Capsules +2 more
    PhasePhase 1
    Registry statusCompleted

  • Effectiveness of Combined Levetiracetam and Midazolam in Generalized Convulsive Status Epilepticus in Children

    NCT04926844 · start 2021-06-20

    Registered record
    Registry ID
    NCT04926844
    Conditions
    Status Epilepticus; Generalized Convulsive Status Epilepticus; Status Epilepticus, Generalized; Status Epilepticus, Generalized Convulsive
    Interventions
    Levetiracetam; Midazolam; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-06-20
    Completion
    2022-09-01
    Enrolment
    144

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStatus Epilepticus; Generalized Convulsive Status Epilepticus; Status Epilepticus, Generalized; Status Epilepticus, Generalized Convulsive
    InterventionLevetiracetam; Midazolam; Placebo
    PhasePhase 2
    Registry statusCompleted

  • A Study of LY3484356 in Healthy Female Participants

    NCT04840888 · start 2021-04-26

    Registered record
    Registry ID
    NCT04840888
    Conditions
    Healthy
    Interventions
    LY3484356; Omeprazole; Itraconazole; Carbamazepine; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2021-04-26
    Completion
    2022-04-12
    Enrolment
    82

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionLY3484356; Omeprazole; Itraconazole; Carbamazepine +1 more
    PhasePhase 1
    Registry statusCompleted