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AMR Drug RepurposingSmart Screeningresearch prototype

Minocycline Hydrochloride

FDA-approved product (capsule, oral), marketed as Amzeeq, Arestin, Dynacin and 7 more.

Registered studies
50+
Lab records
26
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Minocycline Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Bacterial disease
  • Conjunctivitis
  • Infection
  • Ornithosis
  • Periodontitis
  • Respiratory tract infectious disorder
  • Rosacea
  • Spotted fever

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Antiinfectives for treatment of acne; Tetracyclines
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC D10AF07; WHO ATC J01AA08

Repurposing investigation

Minocycline Hydrochloride is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA89.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli89.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae98.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis80.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 4 of 4 lab records
  • E. coli: measured active in 3 of 3 lab records
  • K. pneumoniae: measured active in 14 of 17 lab records
  • M. tuberculosis: measured active in 2 of 2 lab records
Open Minocycline Hydrochloride in ChEMBL Registered studies below
Show the 26 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Minocycline Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Evaluating the Role of Neuroinflammation in Low Back Pain

    NCT03106740 · start 2017-10-10

    Registered record
    Registry ID
    NCT03106740
    Conditions
    Low Back Pain; Back Pain With Radiation; Back Pain Without Radiation; Back Pain Lower Back Chronic; Back Ache; Pain, Chronic
    Interventions
    Minocycline Hydrochloride 100mg Capsule; Magnetic Resonance-Positron Emission Tomography Imaging; Placebo Capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-10-10
    Completion
    2024-04-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain; Back Pain With Radiation; Back Pain Without Radiation; Back Pain Lower Back Chronic +2 more
    InterventionMinocycline Hydrochloride 100mg Capsule; Magnetic Resonance-Positron Emission Tomography Imaging; Placebo Capsule
    PhasePhase 2
    Registry statusCompleted

  • A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules

    NCT03340961 · start 2017-10-01

    Registered record
    Registry ID
    NCT03340961
    Conditions
    Rosacea
    Interventions
    DFD-29 Extended Release Capsules (40 mg); DFD-29 Extended Release Capsules (20 mg); Oraycea® (doxycycline) Capsules; Placebo Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-10-01
    Completion
    2019-03-31
    Enrolment
    205

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRosacea
    InterventionDFD-29 Extended Release Capsules (40 mg); DFD-29 Extended Release Capsules (20 mg); Oraycea® (doxycycline) Capsules; Placebo Capsules
    PhasePhase 2
    Registry statusCompleted

  • Measuring Brain Inflammation in Autism

    NCT03117530 · start 2017-04-11

    Registered record
    Registry ID
    NCT03117530
    Conditions
    Autism Spectrum Disorder
    Interventions
    Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Suspended
    Start
    2017-04-11
    Completion
    2022-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutism Spectrum Disorder
    InterventionMinocycline
    PhasePhase 1
    Registry statusSuspended

  • Minocycline and Tobacco Craving in Smokers With Schizophrenia

    NCT02968602 · start 2017-03-31

    Registered record
    Registry ID
    NCT02968602
    Conditions
    Schizophrenia; Tobacco Use
    Interventions
    Minocycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-03-31
    Completion
    2019-07-23
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Tobacco Use
    InterventionMinocycline; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration

    NCT02564978 · start 2016-12-14

    Registered record
    Registry ID
    NCT02564978
    Conditions
    Age-Related Macular Degeneration
    Interventions
    Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-12-14
    Completion
    2023-03-08
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAge-Related Macular Degeneration
    InterventionMinocycline
    PhasePhase 2
    Registry statusCompleted

  • A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

    NCT02770378 · start 2016-11

    Registered record
    Registry ID
    NCT02770378
    Conditions
    Glioblastoma
    Interventions
    Temozolomide; Aprepitant; Minocycline; Disulfiram; Celecoxib; Sertraline; Captopril; Itraconazole; Ritonavir; Auranofin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2016-11
    Completion
    2020-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlioblastoma
    InterventionTemozolomide; Aprepitant; Minocycline; Disulfiram +6 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Local Minocycline in Patients Under Supportive Periodontal Therapy

    NCT04036890 · start 2016-06-03

    Registered record
    Registry ID
    NCT04036890
    Conditions
    Periodontitis
    Interventions
    2% minocycline hydrochloride controlled-delivery system (MHS); Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-06-03
    Completion
    2019-10-18
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis
    Intervention2% minocycline hydrochloride controlled-delivery system (MHS); Placebos
    PhasePhase 4
    Registry statusCompleted

  • A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne

    NCT02815280 · start 2016-05

    Registered record
    Registry ID
    NCT02815280
    Conditions
    Acne Vulgaris
    Interventions
    FMX-101, 4% minocycline foam; Vehicle Foam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-05
    Completion
    2017-10-13
    Enrolment
    495

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionFMX-101, 4% minocycline foam; Vehicle Foam
    PhasePhase 3
    Registry statusCompleted

  • A Pharmacokinetic Study of Minocycline in Male and Female Volunteers

    NCT02250859 · start 2014-09

    Registered record
    Registry ID
    NCT02250859
    Conditions
    Acne
    Interventions
    FMX101, Minocycline 4% foam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-09
    Completion
    2015-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne
    InterventionFMX101, Minocycline 4% foam
    PhasePhase 1
    Registry statusCompleted

  • The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline

    NCT02060149 · start 2014-03

    Registered record
    Registry ID
    NCT02060149
    Conditions
    Pneumonia
    Interventions
    C/S plus minocycline.; nebulization with pH 7.4 solution; nebulization with pH 7.8 solution; No nebulization
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2014-03
    Completion
    2015-04
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionC/S plus minocycline.; nebulization with pH 7.4 solution; nebulization with pH 7.8 solution; No nebulization
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • The Effects of Antibiotic Combinations on Stem Cells

    NCT04713436 · start 2014-01-01

    Registered record
    Registry ID
    NCT04713436
    Conditions
    Stem Cells; Anti-Bacterial Agents
    Interventions
    Differentiation Markers
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-01-01
    Completion
    2017-02-01
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStem Cells; Anti-Bacterial Agents
    InterventionDifferentiation Markers
    PhaseNot recorded
    Registry statusCompleted

  • Use of Minocycline in Intracerebral Hemorrhage

    NCT03040128 · start 2013-06-27

    Registered record
    Registry ID
    NCT03040128
    Conditions
    Intracerebral Hemorrhage
    Interventions
    Minocycline; normal saline infusion
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2013-06-27
    Completion
    2016-11-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Hemorrhage
    InterventionMinocycline; normal saline infusion
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression

    NCT01809340 · start 2013-06

    Registered record
    Registry ID
    NCT01809340
    Conditions
    Depressive Disorder
    Interventions
    Minocycline; Placebo; Ketamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-06
    Completion
    2014-07
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepressive Disorder
    InterventionMinocycline; Placebo; Ketamine
    PhasePhase 2
    Registry statusTerminated

  • Minocycline in Acute Spinal Cord Injury (MASC)

    NCT01828203 · start 2013-06

    Registered record
    Registry ID
    NCT01828203
    Conditions
    Spinal Cord Injuries
    Interventions
    Minocycline; Placebo; Surgical spinal cord decompression; Maintenance of minimum mean arterial pressure (MAP)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2013-06
    Completion
    2018-06
    Enrolment
    248

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Cord Injuries
    InterventionMinocycline; Placebo; Surgical spinal cord decompression; Maintenance of minimum mean arterial pressure (MAP)
    PhasePhase 3
    Registry statusUnknown

  • Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma

    NCT01580969 · start 2012-07-06

    Registered record
    Registry ID
    NCT01580969
    Conditions
    Recurrent Glioma
    Interventions
    Bevacizumab; Minocycline; Radiation
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2012-07-06
    Completion
    2018-05-15
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Glioma
    InterventionBevacizumab; Minocycline; Radiation
    PhasePhase 1 / Phase 2
    Registry statusCompleted