Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Methazolamide

FDA-approved product (tablet, oral), marketed as Methazolamide, Neptazane.

Registered studies
11
Lab records
4
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Methazolamide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Glaucoma
  • Open-angle glaucoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Carbonic anhydrase inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA27.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli19.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae14.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis85.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

11registered studies name this medicine, for any condition. See them below.

Experimental

  • M. tuberculosis: measured active in 4 of 4 lab records
Open Methazolamide in ChEMBL Registered studies below
Show the 4 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-4.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-5.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Methazolamide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance

    NCT05575180 · start 2023-08-11

    Registered record
    Registry ID
    NCT05575180
    Conditions
    High Altitude Effects
    Interventions
    Acetazolamide 250Mg Tab; Methazolamide Pill; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-08-11
    Completion
    2024-02-22
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh Altitude Effects
    InterventionAcetazolamide 250Mg Tab; Methazolamide Pill; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Use of Methazolamide to Lower Intraocular Pressure

    NCT05498103 · start 2023-02-17

    Registered record
    Registry ID
    NCT05498103
    Conditions
    Glaucoma, Open-Angle
    Interventions
    Methazolamide 25 MG; Methazolamide 50 MG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2023-02-17
    Completion
    2024-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma, Open-Angle
    InterventionMethazolamide 25 MG; Methazolamide 50 MG
    PhasePhase 4
    Registry statusActive not recruiting

  • Comparison of Two Different Sedation Protocols During Transvaginal Oocyte Retrieval

    NCT03362021 · start 2018-01-05

    Registered record
    Registry ID
    NCT03362021
    Conditions
    Infertility
    Interventions
    transvaginal oocyte retrieval
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2018-01-05
    Completion
    2019-11-20
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    Interventiontransvaginal oocyte retrieval
    PhaseNot recorded
    Registry statusTerminated

  • Muscle Fatigue and Carbonic Anhydrase Inhibitors

    NCT02758470 · start 2016-11

    Registered record
    Registry ID
    NCT02758470
    Conditions
    Hypoxia
    Interventions
    Acetazolamide; Methazolamide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-11
    Completion
    2017-06-30
    Enrolment
    13

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypoxia
    InterventionAcetazolamide; Methazolamide; Placebo
    PhasePhase 4
    Registry statusCompleted

  • AZ, MZ, and the Pulmonary System Response to Hypoxia

    NCT02760121 · start 2016-05

    Registered record
    Registry ID
    NCT02760121
    Conditions
    Altitude Sickness; Hypertension, Pulmonary
    Interventions
    Acetazolamide; Methazolamide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-05
    Completion
    2016-08
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAltitude Sickness; Hypertension, Pulmonary
    InterventionAcetazolamide; Methazolamide; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Acamprosate and Methazolamide for Essential Tremor

    NCT06312800 · start 2016-03

    Registered record
    Registry ID
    NCT06312800
    Conditions
    Essential Tremor
    Interventions
    Acamprosate; Placebo; Methazolamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2016-03
    Completion
    2017-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Tremor
    InterventionAcamprosate; Placebo; Methazolamide
    PhasePhase 2
    Registry statusWithdrawn

  • Stop Retinal Ganglion Cell Dysfunction Study

    NCT02390284 · start 2015-09

    Registered record
    Registry ID
    NCT02390284
    Conditions
    Glaucoma
    Interventions
    Latanoprost; Bimatoprost; Travoprost; Timolol; Dorzolamide; Brinzolamide; Acetazolamide; Methazolamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-09
    Completion
    2024-10-04
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionLatanoprost; Bimatoprost; Travoprost; Timolol +4 more
    PhasePhase 3
    Registry statusTerminated

  • Three New Ideas to Protect Special Forces From the Stress of High Altitude

    NCT02463357 · start 2015-08

    Registered record
    Registry ID
    NCT02463357
    Conditions
    Mountain Sickness
    Interventions
    Quercetin; Nifedipine extended release; Methazolamide; Metformin; Placebo; Nitrite
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-08
    Completion
    2016-09
    Enrolment
    148

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMountain Sickness
    InterventionQuercetin; Nifedipine extended release; Methazolamide; Metformin +2 more
    PhasePhase 4
    Registry statusCompleted

  • Rapid Acclimatization to Hypoxia at Altitude

    NCT01702025 · start 2012-06

    Registered record
    Registry ID
    NCT01702025
    Conditions
    Physiological Function in Low Oxygen Environment
    Interventions
    Placebo; Aminophylline; Methazolamide; Aminophylline+Methazolamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2012-06
    Completion
    2012-12
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPhysiological Function in Low Oxygen Environment
    InterventionPlacebo; Aminophylline; Methazolamide; Aminophylline+Methazolamide
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Safety Evaluation of Aminophylline and Methazolamide

    NCT01587027 · start 2011-12

    Registered record
    Registry ID
    NCT01587027
    Conditions
    Mountain Sickness
    Interventions
    Aminophylline; Methazolamide; Aminophylline and Methazolamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-12
    Completion
    2012-02
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMountain Sickness
    InterventionAminophylline; Methazolamide; Aminophylline and Methazolamide
    PhasePhase 1
    Registry statusCompleted

  • Improving Tumor Oxygenation in Cervical Cancer

    NCT00257829 · start 2004-07

    Registered record
    Registry ID
    NCT00257829
    Conditions
    Cervical Cancer
    Interventions
    Methazolamide; Cisplatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2004-07
    Completion
    2006-09-20
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCervical Cancer
    InterventionMethazolamide; Cisplatin
    PhasePhase 2
    Registry statusWithdrawn