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AMR Drug RepurposingSmart Screeningresearch prototype

Sufentanil Citrate

FDA-approved product (injectable, injection), marketed as Dsuvia, Sufenta Preservative Free, Sufentanil Citrate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Sufentanil Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Opioid anesthetics
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA38.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis46.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sufentanil Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sufentanil Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Evaluation of the Hemodynamic Effect of Dexmedetomidine in Scheduled Outpatient Surgery

    NCT06082856 · start 2023-10-19

    Registered record
    Registry ID
    NCT06082856
    Conditions
    Anesthesia; Dexmedetomidine; Hemodynamics; Ambulatory Care
    Interventions
    Dexmedetomidine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-10-19
    Completion
    2026-02
    Enrolment
    594

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Dexmedetomidine; Hemodynamics; Ambulatory Care
    InterventionDexmedetomidine; Sufentanil
    PhaseNot applicable
    Registry statusRecruiting

  • Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery

    NCT05662371 · start 2023-08-01

    Registered record
    Registry ID
    NCT05662371
    Conditions
    Opioid Use, Unspecified; Pain, Postoperative
    Interventions
    Nociception Level monitor (NOL); Standard care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-08-01
    Completion
    2027-03-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Use, Unspecified; Pain, Postoperative
    InterventionNociception Level monitor (NOL); Standard care
    PhaseNot applicable
    Registry statusRecruiting

  • Effect of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Surgery

    NCT06405776 · start 2023-06-05

    Registered record
    Registry ID
    NCT06405776
    Conditions
    Colorectal Cancer
    Interventions
    lidocaine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-06-05
    Completion
    2027-06-01
    Enrolment
    276

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionlidocaine; Placebo
    PhaseNot applicable
    Registry statusRecruiting

  • Effect of Mild Sedation and Analgesia on Radial Artery Cannulation in Novice Residents

    NCT05863455 · start 2023-05-17

    Registered record
    Registry ID
    NCT05863455
    Conditions
    Sedation and Analgesia
    Interventions
    mild sedation and analgesia; control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-05-17
    Completion
    2024-10-15
    Enrolment
    108

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSedation and Analgesia
    Interventionmild sedation and analgesia; control
    PhaseNot applicable
    Registry statusCompleted

  • Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes

    NCT05718544 · start 2023-01-30

    Registered record
    Registry ID
    NCT05718544
    Conditions
    Scoliosis Correction; Postoperative Analgesia; Esketamine; Dexmedetomidine; Chronic Postsurgical Pain
    Interventions
    Esketamine; Dexmedetomidine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-01-30
    Completion
    2023-09-07
    Enrolment
    199

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScoliosis Correction; Postoperative Analgesia; Esketamine; Dexmedetomidine +1 more
    InterventionEsketamine; Dexmedetomidine; Sufentanil
    PhasePhase 4
    Registry statusCompleted

  • Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease

    NCT05550714 · start 2022-10-15

    Registered record
    Registry ID
    NCT05550714
    Conditions
    PD - Parkinson's Disease; Dexmedetomidine; Desflurane; Deep Brain Stimulation
    Interventions
    general anesthesia; Conscious sedation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-10-15
    Completion
    2024-09-30
    Enrolment
    188

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPD - Parkinson's Disease; Dexmedetomidine; Desflurane; Deep Brain Stimulation
    Interventiongeneral anesthesia; Conscious sedation
    PhaseNot applicable
    Registry statusUnknown

  • Evaluation of a New Pain Management Protocol Involving Intranasal Sufentanil in the Emergency Room.

    NCT05498831 · start 2022-08-09

    Registered record
    Registry ID
    NCT05498831
    Conditions
    Acute Pain
    Interventions
    Pain assessment at 15 minutes, 30 minutes, 60 minutes, 120 minutes after initial assessment by the triage nurse
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-08-09
    Completion
    2023-02-23
    Enrolment
    245

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    InterventionPain assessment at 15 minutes, 30 minutes, 60 minutes, 120 minutes after initial assessment by the triage nurse
    PhaseNot recorded
    Registry statusCompleted

  • Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy

    NCT05406102 · start 2022-07-10

    Registered record
    Registry ID
    NCT05406102
    Conditions
    Anesthetics; Recovery; Drug Effect; Safety; Psychotropic Drugs; Anesthetics, Intravenous
    Interventions
    Remimazolam; Propofol group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-07-10
    Completion
    2023-06-01
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthetics; Recovery; Drug Effect; Safety +2 more
    InterventionRemimazolam; Propofol group
    PhasePhase 4
    Registry statusUnknown

  • Norepinephrine in Caesarian Section

    NCT05264870 · start 2022-06-09

    Registered record
    Registry ID
    NCT05264870
    Conditions
    Cesarean Section Complications; Hemodynamic Instability; Foetal Stress
    Interventions
    Norepinephrine; Norepinephrine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2022-06-09
    Completion
    2025-08-27
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCesarean Section Complications; Hemodynamic Instability; Foetal Stress
    InterventionNorepinephrine; Norepinephrine
    PhasePhase 4
    Registry statusTerminated

  • Opioid-free Anesthesia and Thoracoscopy Surgery

    NCT05308355 · start 2022-04-04

    Registered record
    Registry ID
    NCT05308355
    Conditions
    Opioid Free Anesthesia; Thoracic Surgery
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-04-04
    Completion
    2023-04-30
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Free Anesthesia; Thoracic Surgery
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • DSUVIA in Patients With SCD VOC Present in the ED

    NCT05388188 · start 2022-03-30

    Registered record
    Registry ID
    NCT05388188
    Conditions
    Sickle-Cell Disease With Crisis
    Interventions
    sublingual sufentanil
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-03-30
    Completion
    2023-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle-Cell Disease With Crisis
    Interventionsublingual sufentanil
    PhaseNot recorded
    Registry statusUnknown

  • OFA in Thoracic Surgery

    NCT05063396 · start 2021-10-01

    Registered record
    Registry ID
    NCT05063396
    Conditions
    Thoracic Cancer
    Interventions
    opioid free anesthesia; Opioid-sparing anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-10-01
    Completion
    2025-12-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThoracic Cancer
    Interventionopioid free anesthesia; Opioid-sparing anesthesia
    PhaseNot applicable
    Registry statusUnknown

  • Comparison of an Opioid-Free Anesthesia Protocol Versus Standard Practices on Early and Late Post-operative Recovery

    NCT04797312 · start 2021-07-12

    Registered record
    Registry ID
    NCT04797312
    Conditions
    Anesthesia; Anesthesia; Adverse Effect; Opioid Analgesic Adverse Reaction; Post-Op Complication
    Interventions
    Opioid Free Anaesthesia protocol; standard practice protocol based on the use of opioids (sufentanil or remifentanil)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2021-07-12
    Completion
    2023-05
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Anesthesia; Adverse Effect; Opioid Analgesic Adverse Reaction +1 more
    InterventionOpioid Free Anaesthesia protocol; standard practice protocol based on the use of opioids (sufentanil or remifentanil)
    PhasePhase 3
    Registry statusUnknown

  • Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

    NCT04532606 · start 2021-02-05

    Registered record
    Registry ID
    NCT04532606
    Conditions
    Benzodiazepines; Bladder Cancer; Delirium; Surgery; Cancer Recurrence
    Interventions
    Remimazolam; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2021-02-05
    Completion
    2026-10
    Enrolment
    1,128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenzodiazepines; Bladder Cancer; Delirium; Surgery +1 more
    InterventionRemimazolam; Propofol
    PhasePhase 4
    Registry statusRecruiting

  • Consistency Evaluation of the qCON, qNOX Indices and Bispectral Index

    NCT04562181 · start 2020-09-30

    Registered record
    Registry ID
    NCT04562181
    Conditions
    Anesthesia Monitor; Electroencephalography; Sleep
    Interventions
    Bispectral index and qCON/qNOX monitoring
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-09-30
    Completion
    2021-11-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia Monitor; Electroencephalography; Sleep
    InterventionBispectral index and qCON/qNOX monitoring
    PhaseNot applicable
    Registry statusCompleted