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AMR Drug RepurposingSmart Screeningresearch prototype

Sufentanil Citrate

FDA-approved product (injectable, injection), marketed as Dsuvia, Sufenta Preservative Free, Sufentanil Citrate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Sufentanil Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Opioid anesthetics
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA38.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis46.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sufentanil Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sufentanil Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • the Effect of Different Drugs and Infusion Ways on Degree of Postoperative Comfort

    NCT04111328 · start 2019-10-08

    Registered record
    Registry ID
    NCT04111328
    Conditions
    Analgesia, Patient-Controlled
    Interventions
    intravenous sufentanil; subcutaneous sufentanil; intravenous hydromorphone; subcutaneous hydromorphone; intravenous sufentanil and dexmedetomidine; subcutaneous sufentanil and dexmedetomidine; intravenous hydromorphone and dexmedetomidine; subcutaneous hydromorphone and dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-10-08
    Completion
    2020-10-30
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnalgesia, Patient-Controlled
    Interventionintravenous sufentanil; subcutaneous sufentanil; intravenous hydromorphone; subcutaneous hydromorphone +4 more
    PhasePhase 4
    Registry statusCompleted

  • Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)

    NCT03726268 · start 2018-11-29

    Registered record
    Registry ID
    NCT03726268
    Conditions
    Opioid Use; Pain, Postoperative
    Interventions
    Methadone; Fentanyl; Hydromorphone; Morphine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-11-29
    Completion
    2024-01-30
    Enrolment
    907

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Use; Pain, Postoperative
    InterventionMethadone; Fentanyl; Hydromorphone; Morphine +1 more
    PhasePhase 4
    Registry statusCompleted

  • Narcotrend Versus Bispectral Index Monitoring During Sufentanil-Midazolam Anesthesia for Bronchoscopy

    NCT03738137 · start 2018-08-01

    Registered record
    Registry ID
    NCT03738137
    Conditions
    Bronchoscopy
    Interventions
    Narotrend; BIS; Sufentanil; Lidocaine; Midazolam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-08-01
    Completion
    2019-01-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchoscopy
    InterventionNarotrend; BIS; Sufentanil; Lidocaine +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Sufentanil Sublingual Tablet System for Postoperative Pain Management After Total Knee Arthroplasty

    NCT04448457 · start 2017-09-01

    Registered record
    Registry ID
    NCT04448457
    Conditions
    Postoperative Pain
    Interventions
    Sufentanil Sublingual Tablet; Oxycodone oral tablet and oxycodone extended-release oral tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-09-01
    Completion
    2018-07-31
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionSufentanil Sublingual Tablet; Oxycodone oral tablet and oxycodone extended-release oral tablet
    PhaseNot applicable
    Registry statusCompleted

  • Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

    NCT02625181 · start 2016-07

    Registered record
    Registry ID
    NCT02625181
    Conditions
    Postoperative Nausea and Vomiting
    Interventions
    Automated recommendation at the start of the case; Automated notification at the start of surgery; Preoperative recommendations: by email; Automated notification at the end of surgery; Anesthesia Information Management System (AIMS); Perioperative Data Warehouse (PDW); General anesthesia; Elective surgery; Propofol; Sevoflurane; Isoflurane; Desflurane; Scopolamine; Droperidol; Haloperidol; Dexamethasone; Promethazine; Meclizine; Aprepitant; Metoclopramide; Fentanyl; Sufentanil; Alfentanil; Remifentanil; Morphine; Meperidine; Hydromorphone; Methadone; Oxycodone; Oxymorphone; Hydrocodone; Ketamine; Ondansetron; Granisetron; Dolasetron mesylate; Palonosetron; Tropisetron; Ramosetron
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-07
    Completion
    2017-11-30
    Enrolment
    27,034

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Nausea and Vomiting
    InterventionAutomated recommendation at the start of the case; Automated notification at the start of surgery; Preoperative recommendations: by email; Automated notification at the end of surgery +34 more
    PhaseNot applicable
    Registry statusCompleted

  • A Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg in Patients With Post-Operative Pain

    NCT02662556 · start 2016-03

    Registered record
    Registry ID
    NCT02662556
    Conditions
    Acute Moderate-to-severe Pain
    Interventions
    sufentanil sublingual tablet 30 mcg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-03
    Completion
    2016-07
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Moderate-to-severe Pain
    Interventionsufentanil sublingual tablet 30 mcg
    PhasePhase 3
    Registry statusCompleted

  • Laparoscopic Surgery and Abdominal Compliance

    NCT02816567 · start 2016-01

    Registered record
    Registry ID
    NCT02816567
    Conditions
    Patients Ongoing Elective Abdominal Laparoscopy
    Interventions
    propofol; NMBA - cisatracurium; placebo - isotonic saline serum; sufentanil; laparoscopic surgery
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-01
    Completion
    Not recorded
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients Ongoing Elective Abdominal Laparoscopy
    Interventionpropofol; NMBA - cisatracurium; placebo - isotonic saline serum; sufentanil +1 more
    PhasePhase 4
    Registry statusUnknown

  • A Multicenter Study: Dexmedetomidine Combined With Sufentanil for Patient Controlled Intravenous Analgesia After Caesarean Section

    NCT02741219 · start 2015-11

    Registered record
    Registry ID
    NCT02741219
    Conditions
    Postoperative Pain
    Interventions
    Normal saline; Dexmedetomidine; Sufentanil; Sufentanil and dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-11
    Completion
    2016-01
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionNormal saline; Dexmedetomidine; Sufentanil; Sufentanil and dexmedetomidine
    PhasePhase 4
    Registry statusCompleted

  • Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery

    NCT02552459 · start 2015-09

    Registered record
    Registry ID
    NCT02552459
    Conditions
    Arteriovenous Malformation
    Interventions
    Sufentanil; dexmedetomidine 1; dexmedetomidine 2; dexmedetomidine 3
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-09
    Completion
    2016-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArteriovenous Malformation
    InterventionSufentanil; dexmedetomidine 1; dexmedetomidine 2; dexmedetomidine 3
    PhasePhase 4
    Registry statusUnknown

  • Determination of Sufentanil in Breast Milk of Puerpera

    NCT03764202 · start 2015-08

    Registered record
    Registry ID
    NCT03764202
    Conditions
    Cesarean Section
    Interventions
    Detection of sufentanil concentration
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-08
    Completion
    2017-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCesarean Section
    InterventionDetection of sufentanil concentration
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Desflurane on Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting

    NCT02213718 · start 2014-07

    Registered record
    Registry ID
    NCT02213718
    Conditions
    Coronary Artery Bypass Graft Redo; General Anesthetic Drug Adverse Reaction
    Interventions
    Desflurane; propofol; sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-07
    Completion
    2017-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Bypass Graft Redo; General Anesthetic Drug Adverse Reaction
    InterventionDesflurane; propofol; sufentanil
    PhasePhase 4
    Registry statusUnknown

  • PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous

    NCT01856166 · start 2013-06

    Registered record
    Registry ID
    NCT01856166
    Conditions
    Pregnancy
    Interventions
    Release analgesia by CADD SMITHS PCEA pump; Release analgesia by CADD SMITHS PIEB pump; Levobupivacaine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-06
    Completion
    2016-06
    Enrolment
    304

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy
    InterventionRelease analgesia by CADD SMITHS PCEA pump; Release analgesia by CADD SMITHS PIEB pump; Levobupivacaine; Sufentanil
    PhaseNot applicable
    Registry statusCompleted

  • Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass

    NCT05011617 · start 2012-04-01

    Registered record
    Registry ID
    NCT05011617
    Conditions
    Monitored Anesthesia Care; Cardiac Surgery; Postoperative Recovery
    Interventions
    Non-intubation and monitoring anesthesia care (MAC)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-04-01
    Completion
    2021-12-31
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMonitored Anesthesia Care; Cardiac Surgery; Postoperative Recovery
    InterventionNon-intubation and monitoring anesthesia care (MAC)
    PhaseNot applicable
    Registry statusCompleted

  • A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain

    NCT01539538 · start 2012-04

    Registered record
    Registry ID
    NCT01539538
    Conditions
    Post-Operative Pain
    Interventions
    Sufentanil NanoTab PCA System/15 mcg; morphine IV PCA
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-04
    Completion
    2012-12
    Enrolment
    357

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-Operative Pain
    InterventionSufentanil NanoTab PCA System/15 mcg; morphine IV PCA
    PhasePhase 3
    Registry statusCompleted

  • Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery

    NCT01384643 · start 2011-05

    Registered record
    Registry ID
    NCT01384643
    Conditions
    Heart Valve Disease
    Interventions
    Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2012-05
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Valve Disease
    InterventionPropofol
    PhasePhase 4
    Registry statusCompleted