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AMR Drug RepurposingSmart Screeningresearch prototype

Cefotaxime Sodium

FDA-approved product (injectable, injection), marketed as Cefotaxime, Cefotaxime And Dextrose 2.4% In Plastic Container, Cefotaxime And Dextrose 3.9% In Plastic Container and 4 more.

Registered studies
28
Lab records
300
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cefotaxime Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Gonorrhea
  • Infection
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Third-generation cephalosporins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DD01

Repurposing investigation

Cefotaxime Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA89.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae34.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis51.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

28registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 11 of 16 lab records
  • E. coli: measured active in 37 of 37 lab records
  • K. pneumoniae: measured active in 118 of 247 lab records
Open Cefotaxime Sodium in ChEMBL Registered studies below
Show the latest 150 of 300 laboratory records, with sources

Loading records…

Every record is in ChEMBL, linked above. “Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefotaxime Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury

    NCT06819592 · start 2025-10-30

    Registered record
    Registry ID
    NCT06819592
    Conditions
    All-cause Mortality; Quality of Life; Disability, Intellectual; Neurological Disorder; Acute Brain Injury; Ventilation, Mechanical; Intensive Care Medicine
    Interventions
    Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride; Placebo comparator - no ceftriaxone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2025-10-30
    Completion
    2029-12
    Enrolment
    3,300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAll-cause Mortality; Quality of Life; Disability, Intellectual; Neurological Disorder +3 more
    InterventionCeftriaxone 2g diluted in >200ml 0.9%sodium chloride; Placebo comparator - no ceftriaxone
    PhasePhase 3
    Registry statusRecruiting

  • Enhanced Molecular Microbiological Surveillance Versus Ceftriaxone Prophylaxis in Hematopoietic Cell Transplant Patients

    NCT07308457 · start 2024-09-01

    Registered record
    Registry ID
    NCT07308457
    Conditions
    Incidence of Infectious Diseases
    Interventions
    Ceftriaxone 1000 MG
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-09-01
    Completion
    2027-10-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIncidence of Infectious Diseases
    InterventionCeftriaxone 1000 MG
    PhaseNot applicable
    Registry statusRecruiting

  • Parenteral Versus Combined Parenteral With Vancomycin-soaked Graft in ACL Reconstruction

    NCT06166381 · start 2024-01-25

    Registered record
    Registry ID
    NCT06166381
    Conditions
    Infection, Bacterial
    Interventions
    Parenteral Antibacterial Agents; Parenteral Antibacterial Agents plus Vancomycin pre-soaked graft
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-01-25
    Completion
    2025-02
    Enrolment
    288

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection, Bacterial
    InterventionParenteral Antibacterial Agents; Parenteral Antibacterial Agents plus Vancomycin pre-soaked graft
    PhaseNot applicable
    Registry statusRecruiting

  • Mecobalamin Combined With Ceftriaxone Sodium in the Treatment of Sepsis Liver Injury

    NCT06220929 · start 2024-01-15

    Registered record
    Registry ID
    NCT06220929
    Conditions
    Sepsis; Liver Dysfunction
    Interventions
    Mecobalamin; Ceftriaxone Sodium; Saline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2024-01-15
    Completion
    2025-01-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis; Liver Dysfunction
    InterventionMecobalamin; Ceftriaxone Sodium; Saline; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Antibiotic Instillation in Appendicitis

    NCT05470517 · start 2023-01-05

    Registered record
    Registry ID
    NCT05470517
    Conditions
    Complicated Appendicitis; Acute Appendicitis
    Interventions
    Ceftriaxone; Intra-peritoneal Fluid Aspiration
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2023-01-05
    Completion
    2024-03-20
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Appendicitis; Acute Appendicitis
    InterventionCeftriaxone; Intra-peritoneal Fluid Aspiration
    PhasePhase 2
    Registry statusCompleted

  • Prophylactic Antibiotic Use in Transarterial Chemoembolization for Hepatocellular Carcinoma

    NCT05654896 · start 2022-11-26

    Registered record
    Registry ID
    NCT05654896
    Conditions
    Antibiotic Prophylaxis
    Interventions
    Ceftriaxone Sodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2022-11-26
    Completion
    2023-12-26
    Enrolment
    158

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotic Prophylaxis
    InterventionCeftriaxone Sodium
    PhasePhase 3
    Registry statusUnknown

  • PROPER Trial of Pain and Inflammation After Knee Arthroscopy

    NCT05149287 · start 2021-12-28

    Registered record
    Registry ID
    NCT05149287
    Conditions
    Meniscus Tear; Meniscus Lesion; Cartilage Injury
    Interventions
    Ceftriaxone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2021-12-28
    Completion
    2022-04-29
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMeniscus Tear; Meniscus Lesion; Cartilage Injury
    InterventionCeftriaxone; Placebo
    PhasePhase 2
    Registry statusTerminated

  • A Multi-center Clinical Study of Drug Antibody and Precision Transfusion in China

    NCT05606302 · start 2021-10-01

    Registered record
    Registry ID
    NCT05606302
    Conditions
    Drug-specific Antibodies
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2021-10-01
    Completion
    2023-12
    Enrolment
    14,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug-specific Antibodies
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Assessing Parenteral Antibiotics Versus Single-time Intra-operative Intra-dermal Antibiotic Administration for Prevention of SSI

    NCT04975945 · start 2021-08

    Registered record
    Registry ID
    NCT04975945
    Conditions
    Surgical Wound Infection; Surgical Site Infection
    Interventions
    Ceftriaxone Sodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2021-08
    Completion
    2022-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Wound Infection; Surgical Site Infection
    InterventionCeftriaxone Sodium
    PhasePhase 4
    Registry statusWithdrawn

  • Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition

    NCT05051163 · start 2021-06-14

    Registered record
    Registry ID
    NCT05051163
    Conditions
    HIV-1-infection; Malnutrition, Child
    Interventions
    Ceftriaxone Sodium; Ampicillin; Gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2021-06-14
    Completion
    2024-06-14
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV-1-infection; Malnutrition, Child
    InterventionCeftriaxone Sodium; Ampicillin; Gentamicin
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

    NCT03068741 · start 2020-03-23

    Registered record
    Registry ID
    NCT03068741
    Conditions
    Severe Sepsis or Septic Shock
    Interventions
    Comparison 1: Prehospital Ceftriaxone; Comparison 1: Placebo; Comparison 2: Liberal fluids; Comparison 2: Conservative fluids
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-03-23
    Completion
    2025-11-17
    Enrolment
    2,061

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSevere Sepsis or Septic Shock
    InterventionComparison 1: Prehospital Ceftriaxone; Comparison 1: Placebo; Comparison 2: Liberal fluids; Comparison 2: Conservative fluids
    PhasePhase 4
    Registry statusCompleted

  • Clinical Study of Anerning Particle for the Treatment of Childhood Community-acquired Pneumonia

    NCT03675178 · start 2018-09-22

    Registered record
    Registry ID
    NCT03675178
    Conditions
    Community-acquired Pneumonia
    Interventions
    Anerning particle; control group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-09-22
    Completion
    2019-12-31
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Pneumonia
    InterventionAnerning particle; control group
    PhasePhase 4
    Registry statusUnknown

  • Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery

    NCT03563586 · start 2018-04-01

    Registered record
    Registry ID
    NCT03563586
    Conditions
    Antibiotic; Bowel Cancer; Colorectal Cancer; Surgical Site Infection
    Interventions
    Bowel Preparation plus antibiotics; Bowel Preparation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-04-01
    Completion
    2021-06-01
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotic; Bowel Cancer; Colorectal Cancer; Surgical Site Infection
    InterventionBowel Preparation plus antibiotics; Bowel Preparation
    PhaseNot applicable
    Registry statusUnknown

  • A Study Evaluating Efficacy and Safety of CRO-SBT in the Treatment of Gonorrhea

    NCT04202068 · start 2015-07-03

    Registered record
    Registry ID
    NCT04202068
    Conditions
    Gonorrhea
    Interventions
    Ceftriaxone sodium and Sulbactam Sodium for injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-07-03
    Completion
    2016-05-30
    Enrolment
    113

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGonorrhea
    InterventionCeftriaxone sodium and Sulbactam Sodium for injection
    PhasePhase 4
    Registry statusCompleted

  • PHase IV Clinical Trial of Ceftriaxone Sodium and Sulbactam Sodium for Injection (CRO-SBT)

    NCT04066621 · start 2015-04-28

    Registered record
    Registry ID
    NCT04066621
    Conditions
    Respiratory Tract Infections; Urinary Tract Infections in Children
    Interventions
    Ceftriaxone Sodium and Sulbactam Sodium for Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04-28
    Completion
    2017-05-27
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Tract Infections; Urinary Tract Infections in Children
    InterventionCeftriaxone Sodium and Sulbactam Sodium for Injection
    PhasePhase 4
    Registry statusCompleted