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AMR Drug RepurposingSmart Screeningresearch prototype

Clavulanate Potassium

FDA-approved product (tablet, oral).

Registered studies
50+
Lab records
28
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Clavulanate Potassium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Infection
  • Infectious otitis media
  • Otitis media
  • Pneumonia
  • Respiratory tract infectious disorder
  • Sinusitis
  • Soft Tissue Infections
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Combinations of penicillins, incl. beta-lactamase inhibitors
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CR02

Repurposing investigation

Clavulanate Potassium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA4.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli74.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae73.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis39.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 8 lab records
  • E. coli: measured active in 9 of 16 lab records
  • K. pneumoniae: measured active in 4 of 4 lab records
Open Clavulanate Potassium in ChEMBL Registered studies below
Show the 28 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-5.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clavulanate Potassium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation

    NCT07759453 · start 2026-10-01

    Registered record
    Registry ID
    NCT07759453
    Conditions
    Liver Transplant; Carbapenem-resistant Enterobacterales; CRE Colonization
    Interventions
    Ceftazidime - Avibactam ( CAZ-AVI); Meropenem-Vaborbactam; Imipenem+Relebactam; Cefiderocol; Aztreonam; Eravacycline; Aztreonam-Avibactam; Amoxi Clavulanate; Piperacillin + Tazobactam; Tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2029-09-30
    Enrolment
    168

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplant; Carbapenem-resistant Enterobacterales; CRE Colonization
    InterventionCeftazidime - Avibactam ( CAZ-AVI); Meropenem-Vaborbactam; Imipenem+Relebactam; Cefiderocol +6 more
    PhasePhase 3
    Registry statusNot yet recruiting

  • Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP

    NCT06494072 · start 2024-08-22

    Registered record
    Registry ID
    NCT06494072
    Conditions
    Community Acquired Pneumonia in Children
    Interventions
    Ampicillin for Injection; Ceftriaxone for Injection; Amoxicillin; Ampicillin / Sulbactam Injection; Amoxicillin-clavulanate; Clindamycin; Cefprozil; Levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2024-08-22
    Completion
    2028-05
    Enrolment
    236

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity Acquired Pneumonia in Children
    InterventionAmpicillin for Injection; Ceftriaxone for Injection; Amoxicillin; Ampicillin / Sulbactam Injection +4 more
    PhasePhase 4
    Registry statusRecruiting

  • eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce CR-POPF

    NCT05753735 · start 2024-01-18

    Registered record
    Registry ID
    NCT05753735
    Conditions
    Pancreatic Fistula
    Interventions
    Piperacillin/Tazobactam; Amoxicillin/ Clavulanic acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2024-01-18
    Completion
    2024-06-02
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPancreatic Fistula
    InterventionPiperacillin/Tazobactam; Amoxicillin/ Clavulanic acid
    PhasePhase 2
    Registry statusTerminated

  • Prophylactic Antibiotic in Non-complicated Low Risk Lap Cholecystectomy (LC)

    NCT06193837 · start 2024-01-01

    Registered record
    Registry ID
    NCT06193837
    Conditions
    Cholecystectomy, Laparoscopic
    Interventions
    Augmentin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-01-01
    Completion
    2026-01-01
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholecystectomy, Laparoscopic
    InterventionAugmentin
    PhaseNot recorded
    Registry statusUnknown

  • CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)

    NCT05846399 · start 2023-09-07

    Registered record
    Registry ID
    NCT05846399
    Conditions
    Cat Bite; Hand Injuries; Arm Injury; Infection, Bacterial; Anti-bacterial Agents
    Interventions
    Amoxicillin/clavulanate; Ciprofloxacin; Clindamycin; Placebo (microcrystalline cellulose); Wound management
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2023-09-07
    Completion
    2027-08-01
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCat Bite; Hand Injuries; Arm Injury; Infection, Bacterial +1 more
    InterventionAmoxicillin/clavulanate; Ciprofloxacin; Clindamycin; Placebo (microcrystalline cellulose) +1 more
    PhasePhase 4
    Registry statusRecruiting

  • Antibiotics, Microbiology and Immunology in Children With Chronic Wet Cough - the AMIC Study

    NCT06020716 · start 2023-08-16

    Registered record
    Registry ID
    NCT06020716
    Conditions
    Protracted Bacterial Bronchitis
    Interventions
    Amoxicillin-Clavulanate 400 Mg-57 Mg/5 mL Oral Powder for Reconstitution; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2023-08-16
    Completion
    2028-04-30
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProtracted Bacterial Bronchitis
    InterventionAmoxicillin-Clavulanate 400 Mg-57 Mg/5 mL Oral Powder for Reconstitution; Placebo
    PhasePhase 4
    Registry statusRecruiting

  • A Pharmacokinetic Study of LP-001 in Children With a Bacterial Infection

    NCT05584683 · start 2023-08-09

    Registered record
    Registry ID
    NCT05584683
    Conditions
    Pediatric; Bacterial Infections
    Interventions
    Amoxicillin potassium clavulanate; Amoxicillin potassium clavulanate (Augmentin ES-600)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2023-08-09
    Completion
    2024-12-16
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric; Bacterial Infections
    InterventionAmoxicillin potassium clavulanate; Amoxicillin potassium clavulanate (Augmentin ES-600)
    PhasePhase 1
    Registry statusCompleted

  • Comparing Oral Versus Parenteral Antimicrobial Therapy

    NCT05977868 · start 2023-08-04

    Registered record
    Registry ID
    NCT05977868
    Conditions
    Endovascular Infection; Bone and Joint Infection; Skin and Soft Tissue Infection; Pulmonary Infection; Gastrointestinal Infection; Genitourinary Infection
    Interventions
    Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid; Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2023-08-04
    Completion
    2025-02-14
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndovascular Infection; Bone and Joint Infection; Skin and Soft Tissue Infection; Pulmonary Infection +2 more
    InterventionAmoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid; Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem
    PhasePhase 4
    Registry statusTerminated

  • Effects of Antibiotic Prophylaxis on the Healing Parameters Following Surgical Crown Lengthening

    NCT05925179 · start 2023-08-01

    Registered record
    Registry ID
    NCT05925179
    Conditions
    Tooth Diseases; Tooth Wear
    Interventions
    Surgical crown lengthening; Augmentin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2023-08-01
    Completion
    2024-01-01
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTooth Diseases; Tooth Wear
    InterventionSurgical crown lengthening; Augmentin
    PhasePhase 4
    Registry statusUnknown

  • Clavulanic Acid for the Treatment of Cocaine Use Disorder

    NCT05562349 · start 2023-05-03

    Registered record
    Registry ID
    NCT05562349
    Conditions
    Cocaine Dependence
    Interventions
    Clavulanic Acid Only Product; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2023-05-03
    Completion
    2024-07
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine Dependence
    InterventionClavulanic Acid Only Product; Placebo
    PhasePhase 2
    Registry statusActive not recruiting

  • Collaborative Urological Prosthetics Investigation Directive Research Group

    NCT05100654 · start 2022-04-22

    Registered record
    Registry ID
    NCT05100654
    Conditions
    Erectile Dysfunction; Penile Prosthesis Infection
    Interventions
    Doxycycline; Ciprofloxacin; Augmentin; Bactrim
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Active not recruiting
    Start
    2022-04-22
    Completion
    2028-01-01
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction; Penile Prosthesis Infection
    InterventionDoxycycline; Ciprofloxacin; Augmentin; Bactrim
    PhaseEarly phase 1
    Registry statusActive not recruiting

  • Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery

    NCT05392634 · start 2022-02-02

    Registered record
    Registry ID
    NCT05392634
    Conditions
    Bladder Cancer
    Interventions
    Meropenem 1000 mg; Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2022-02-02
    Completion
    2023-11-01
    Enrolment
    98

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBladder Cancer
    InterventionMeropenem 1000 mg; Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg
    PhasePhase 3
    Registry statusUnknown

  • LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media

    NCT05804123 · start 2021-10-28

    Registered record
    Registry ID
    NCT05804123
    Conditions
    Upper Respiratory Tract Infections
    Interventions
    0.9% NaCl physiological saline Nasal-spraying; LiveSpo Navax®; Augmentin 500Mg Tablet; Acetylcysteine; Xylometazoline Nasal; Cefotaxime; Ciprofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-10-28
    Completion
    2024-08-01
    Enrolment
    175

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUpper Respiratory Tract Infections
    Intervention0.9% NaCl physiological saline Nasal-spraying; LiveSpo Navax®; Augmentin 500Mg Tablet; Acetylcysteine +3 more
    PhaseNot applicable
    Registry statusCompleted

  • Prophylaxis of Surgical Wound Infection in Incisional Hernia Repair With Topical Antibiotics (PROTOP-PAR)

    NCT05508152 · start 2021-02-01

    Registered record
    Registry ID
    NCT05508152
    Conditions
    Postoperative Hernia
    Interventions
    Wound irrigation with amoxicillin-clavulanate in saline solution; Wound irrigation with a saline solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-02-01
    Completion
    2023-06-30
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Hernia
    InterventionWound irrigation with amoxicillin-clavulanate in saline solution; Wound irrigation with a saline solution
    PhasePhase 3
    Registry statusCompleted

  • Mechanisms of Probiotics and Antibiotic-Associated Diarrhea

    NCT04414722 · start 2021-01-01

    Registered record
    Registry ID
    NCT04414722
    Conditions
    Antibiotic-associated Diarrhea
    Interventions
    Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet; BB-12; Control Yogurt
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2021-01-01
    Completion
    2023-05-01
    Enrolment
    118

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotic-associated Diarrhea
    InterventionAmoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet; BB-12; Control Yogurt
    PhaseEarly phase 1
    Registry statusCompleted