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AMR Drug RepurposingSmart Screeningresearch prototype

Trimethoprim

FDA-approved product (tablet, oral), marketed as Proloprim, Trimethoprim, Trimpex and 2 more.

Registered studies
50+
Lab records
56
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Trimethoprim
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Otitis media
  • Pneumocystosis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Trimethoprim and derivatives
FDA pharmacologic class
Dihydrofolate Reductase Inhibitor Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01EA01; FDA class Dihydrofolate Reductase Inhibitor Antibacterial

Repurposing investigation

Trimethoprim is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA79.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae76.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis9.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 7 of 8 lab records
  • E. coli: measured active in 32 of 33 lab records
  • K. pneumoniae: measured active in 7 of 12 lab records
  • M. tuberculosis: measured active in 0 of 3 lab records
Open Trimethoprim in ChEMBL Registered studies below
Show the 56 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Trimethoprim with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria

    NCT02134106 · start 2015-01

    Registered record
    Registry ID
    NCT02134106
    Conditions
    Bacteremia; Healthcare-associated Pneumonia; Ventilator-associated Pneumonia
    Interventions
    Polymyxin B; Polymyxin B + Doripenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Withdrawn
    Start
    2015-01
    Completion
    2015-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia; Healthcare-associated Pneumonia; Ventilator-associated Pneumonia
    InterventionPolymyxin B; Polymyxin B + Doripenem
    PhasePhase 2 / Phase 3
    Registry statusWithdrawn

  • Antibiotic Irrigation for Pancreatoduodenectomy

    NCT02186457 · start 2014-11

    Registered record
    Registry ID
    NCT02186457
    Conditions
    Surgery; Infection
    Interventions
    Polymyxin B in Normal Saline; Placebo: Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-11
    Completion
    2019-08
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery; Infection
    InterventionPolymyxin B in Normal Saline; Placebo: Normal Saline
    PhaseNot applicable
    Registry statusCompleted

  • The Effects of a Polyethyleneimine-coated Membrane (oXiris™) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxin™) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)

    NCT01948778 · start 2013-08

    Registered record
    Registry ID
    NCT01948778
    Conditions
    Patients in Septic Shock
    Interventions
    oXiris™ filter; Toraymyxin Filter; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-08
    Completion
    2019-07
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients in Septic Shock
    InterventionoXiris™ filter; Toraymyxin Filter; Standard of Care
    PhaseNot applicable
    Registry statusCompleted

  • Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents

    NCT02873806 · start 2013-03

    Registered record
    Registry ID
    NCT02873806
    Conditions
    Open-angle Glaucoma
    Interventions
    Implantation of two iStent inject micro-bypass stents; Topical travoprost; Two iStent inject micro-bypass stents; Tobramycin; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-03
    Completion
    2019-11-08
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen-angle Glaucoma
    InterventionImplantation of two iStent inject micro-bypass stents; Topical travoprost; Two iStent inject micro-bypass stents; Tobramycin +1 more
    PhasePhase 4
    Registry statusCompleted

  • Endotoxin Adsorber Hemoperfusion and Microcirculation

    NCT01756755 · start 2012-12

    Registered record
    Registry ID
    NCT01756755
    Conditions
    Sepsis
    Interventions
    PMX-20R Hemoperfusion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-12
    Completion
    2019-06
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis
    InterventionPMX-20R Hemoperfusion
    PhaseNot applicable
    Registry statusCompleted

  • Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients

    NCT01809483 · start 2012-09

    Registered record
    Registry ID
    NCT01809483
    Conditions
    Erosion; Cornea, Traumatic
    Interventions
    Bandage contact lens; Pressure patching
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-09
    Completion
    2013-02
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErosion; Cornea, Traumatic
    InterventionBandage contact lens; Pressure patching
    PhasePhase 3
    Registry statusCompleted

  • Impact of Early Peri-operative Use of Polymyxin-B Hemoperfusion in Septic Patients Undergoing Emergent Abdominal Surgery

    NCT01646229 · start 2012-01

    Registered record
    Registry ID
    NCT01646229
    Conditions
    Abdominal Sepsis; Peritonitis; Colon Perforation
    Interventions
    Polymyxin-B hemoperfusion; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-01
    Completion
    2015-02
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdominal Sepsis; Peritonitis; Colon Perforation
    InterventionPolymyxin-B hemoperfusion; Control
    PhaseNot applicable
    Registry statusCompleted

  • Safety and Efficacy Study of Besivance™ for Treatment of Congenital Nasolacrimal Duct Obstruction in Children

    NCT01431170 · start 2011-09

    Registered record
    Registry ID
    NCT01431170
    Conditions
    Congenital Nasolacrimal Duct Obstruction
    Interventions
    Besivance Treatment Group; Polytrim Treatment Group
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-09
    Completion
    2014-06
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCongenital Nasolacrimal Duct Obstruction
    InterventionBesivance Treatment Group; Polytrim Treatment Group
    PhasePhase 1
    Registry statusCompleted

  • Efficacy Maxinom® And Maxitrol® in Reducing The Signs And Symptoms Of Acute Bacterial Conjunctivitis

    NCT01227863 · start 2011-02

    Registered record
    Registry ID
    NCT01227863
    Conditions
    Bacterial Conjunctivitis; Acute
    Interventions
    MAXINOM®; Maxitrol®
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2011-02
    Completion
    Not recorded
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Conjunctivitis; Acute
    InterventionMAXINOM®; Maxitrol®
    PhasePhase 3
    Registry statusUnknown

  • Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock

    NCT01046669 · start 2010-06

    Registered record
    Registry ID
    NCT01046669
    Conditions
    Septic Shock; Endotoxemia
    Interventions
    TORAYMYXIN PMX-20R (PMX cartridge); Standard medical care for septic shock
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-06
    Completion
    2017-06
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock; Endotoxemia
    InterventionTORAYMYXIN PMX-20R (PMX cartridge); Standard medical care for septic shock
    PhaseNot applicable
    Registry statusCompleted

  • Antibiotic Prophylaxis in Children With Pyelonephritis

    NCT00752375 · start 2009-02

    Registered record
    Registry ID
    NCT00752375
    Conditions
    Pyelonephritis
    Interventions
    Trimethoprim Sulfamethoxazole; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2009-02
    Completion
    2014-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPyelonephritis
    InterventionTrimethoprim Sulfamethoxazole; placebo
    PhasePhase 3
    Registry statusWithdrawn

  • Alcohol 20% for Separation of Pterygium and Comparison of Different Wound Closure Methods

    NCT00704977 · start 2008-06

    Registered record
    Registry ID
    NCT00704977
    Conditions
    Pterygium
    Interventions
    pterygium surgery using alcohol 20% for tissue separation and bare sclera as wound closure technique
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2008-06
    Completion
    2010-07
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPterygium
    Interventionpterygium surgery using alcohol 20% for tissue separation and bare sclera as wound closure technique
    PhaseNot applicable
    Registry statusUnknown

  • Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage

    NCT00534391 · start 2007-09

    Registered record
    Registry ID
    NCT00534391
    Conditions
    Hordeolum
    Interventions
    neomycin sulfate, polymyxin B sulfate and gramicidin; Artificial tear
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2007-09
    Completion
    2008-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHordeolum
    Interventionneomycin sulfate, polymyxin B sulfate and gramicidin; Artificial tear
    PhasePhase 3
    Registry statusUnknown

  • Moxifloxacin vs. Polytrim for Conjunctivitis

    NCT00581542 · start 2007-03

    Registered record
    Registry ID
    NCT00581542
    Conditions
    Conjunctivitis
    Interventions
    moxifloxacin; polytrim
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-03
    Completion
    2012-03
    Enrolment
    124

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConjunctivitis
    Interventionmoxifloxacin; polytrim
    PhasePhase 4
    Registry statusCompleted

  • Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapy

    NCT00695578 · start 2006-10

    Registered record
    Registry ID
    NCT00695578
    Conditions
    Actinic Keratosis
    Interventions
    Biafine; Polysporin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-10
    Completion
    2008-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionBiafine; Polysporin
    PhasePhase 4
    Registry statusCompleted