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AMR Drug RepurposingSmart Screeningresearch prototype

Butorphanol Tartrate

FDA-approved product (injectable, injection), marketed as Butorphanol Tartrate, Butorphanol Tartrate Preservative Free, Stadol and 1 more.

Registered studies
24
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Butorphanol Tartrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Drug dependence
  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Morphinan derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae34.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis45.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

24registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Butorphanol Tartrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Butorphanol Tartrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • EOIB for Pain After Laparoscopic Cholecystectomy

    NCT07332546 · start 2026-01-15

    Registered record
    Registry ID
    NCT07332546
    Conditions
    Postoperative Pain; Laparoscopic Cholecystectomy
    Interventions
    External oblique intercostal block (EOIB); Standard care without regional block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2026-01-15
    Completion
    2026-06-25
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain; Laparoscopic Cholecystectomy
    InterventionExternal oblique intercostal block (EOIB); Standard care without regional block
    PhaseNot applicable
    Registry statusCompleted

  • Butorphanol for Pain Relief After Cesarean Section: A Retrospective Study

    NCT07175363 · start 2025-09-20

    Registered record
    Registry ID
    NCT07175363
    Conditions
    Caesarean Section
    Interventions
    An postoperative analgesic pump was used
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-09-20
    Completion
    2026-06-30
    Enrolment
    2,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCaesarean Section
    InterventionAn postoperative analgesic pump was used
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Effects of Transversus Abdominis Plane Block on Recovery Quality and Maternal-Neonatal Outcomes After Cesarean Delivery

    NCT07478692 · start 2025-06-01

    Registered record
    Registry ID
    NCT07478692
    Conditions
    Postoperative Pain After Cesarean Section
    Interventions
    The TAP block group received ultrasound-guided bilateral TAP block (20 mL of 0.375 % ropivacaine per side) during surgery and postoperative intravenous analgesia pump (formula of butorphanol 2 mg/kg)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-06-01
    Completion
    2025-10-31
    Enrolment
    83

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain After Cesarean Section
    InterventionThe TAP block group received ultrasound-guided bilateral TAP block (20 mL of 0.375 % ropivacaine per side) during surgery and postoperative intravenous analgesia pump (formula of butorphanol 2 mg/kg)
    PhaseNot applicable
    Registry statusCompleted

  • Butorphanol in Pain Following Ablation for Hepatic Tumor

    NCT06031129 · start 2023-03-01

    Registered record
    Registry ID
    NCT06031129
    Conditions
    Visceral Pain; Microwave Ablation; Hepatic Tumor
    Interventions
    Butorphanol; normal saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-03-01
    Completion
    2023-08-09
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVisceral Pain; Microwave Ablation; Hepatic Tumor
    InterventionButorphanol; normal saline
    PhaseNot applicable
    Registry statusCompleted

  • Esketamine and Butorphanol for Post-Lobectomy Pain

    NCT06398834 · start 2022-03-01

    Registered record
    Registry ID
    NCT06398834
    Conditions
    Esketamine; Pain; Post-thoracotomy Pain Syndrome; Thoracic Diseases
    Interventions
    Esketamine; Butorphanol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-03-01
    Completion
    2024-01-01
    Enrolment
    223

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEsketamine; Pain; Post-thoracotomy Pain Syndrome; Thoracic Diseases
    InterventionEsketamine; Butorphanol
    PhasePhase 4
    Registry statusCompleted

  • Study on Gynecological Laparoscopy Under Total Intravenous Anesthesia

    NCT06524596 · start 2022-01-01

    Registered record
    Registry ID
    NCT06524596
    Conditions
    Butorphanol
    Interventions
    tartaric acid butorphanol; normal saline; propofol and remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-01-01
    Completion
    2023-05-01
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionButorphanol
    Interventiontartaric acid butorphanol; normal saline; propofol and remifentanil
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation

    NCT05024799 · start 2022-01

    Registered record
    Registry ID
    NCT05024799
    Conditions
    Respiratory Insufficiency
    Interventions
    Fentanyl, propofol; fentanyl and dexmedetomindine; Butorphanol and propofol; Butorphanol and dexmedetomindine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-01
    Completion
    2024-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Insufficiency
    InterventionFentanyl, propofol; fentanyl and dexmedetomindine; Butorphanol and propofol; Butorphanol and dexmedetomindine
    PhasePhase 4
    Registry statusUnknown

  • Efficacy and Safety of Butorphanol Tartrate Injection for the Patients With Mechanical Ventilation

    NCT05201560 · start 2022-01

    Registered record
    Registry ID
    NCT05201560
    Conditions
    Analgesia; Hospital-acquired Infections
    Interventions
    Butorphanol Tartrate Injection; Fentanyl
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-01
    Completion
    2023-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnalgesia; Hospital-acquired Infections
    InterventionButorphanol Tartrate Injection; Fentanyl
    PhaseNot applicable
    Registry statusUnknown

  • Hydromorphone for ICU-analgesia in Patients With Non-mechanical Ventilation

    NCT04436224 · start 2020-09-04

    Registered record
    Registry ID
    NCT04436224
    Conditions
    Hydromorphone; Analgesia; ICU
    Interventions
    Hydromorphone; Fentanyl; Butorphanol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-09-04
    Completion
    2025-05-30
    Enrolment
    530

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHydromorphone; Analgesia; ICU
    InterventionHydromorphone; Fentanyl; Butorphanol
    PhasePhase 4
    Registry statusCompleted

  • Effect of Butorphanol on Colonoscopy for Patients With Postoperative Visceral Pain

    NCT04477733 · start 2020-08-14

    Registered record
    Registry ID
    NCT04477733
    Conditions
    Colonoscopy
    Interventions
    Butorphanol Injection; Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-08-14
    Completion
    2021-09-30
    Enrolment
    203

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColonoscopy
    InterventionButorphanol Injection; Saline
    PhasePhase 4
    Registry statusCompleted

  • The Analgesic Effect of Butorphanol After Cesarean Section

    NCT04490980 · start 2020-08-01

    Registered record
    Registry ID
    NCT04490980
    Conditions
    Analgesia
    Interventions
    butorphanol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-08-01
    Completion
    2020-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnalgesia
    Interventionbutorphanol
    PhaseNot applicable
    Registry statusUnknown

  • Comparison of the Effects of Fentanyl, Oxycodone, Butorphanol on Gastrointestinal Function

    NCT04295109 · start 2020-03-02

    Registered record
    Registry ID
    NCT04295109
    Conditions
    Cervix Neoplasms; Endometrial Cancer; Adenomyosis; Fibroid Uterus
    Interventions
    the drug of intravenous patient-controlled analgesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-03-02
    Completion
    2020-07-31
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCervix Neoplasms; Endometrial Cancer; Adenomyosis; Fibroid Uterus
    Interventionthe drug of intravenous patient-controlled analgesia
    PhaseNot applicable
    Registry statusUnknown

  • PK/PD of the Sedatives, Analgesics and Antibiotics in Patients Receiving ECMO

    NCT03787550 · start 2020-02-07

    Registered record
    Registry ID
    NCT03787550
    Conditions
    Drug Effect
    Interventions
    The Sedatives, analgesics and antibiotics
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2020-02-07
    Completion
    2022-03-31
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Effect
    InterventionThe Sedatives, analgesics and antibiotics
    PhaseNot recorded
    Registry statusUnknown

  • Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation

    NCT04315935 · start 2019-12-15

    Registered record
    Registry ID
    NCT04315935
    Conditions
    Analgesia
    Interventions
    Butorphanol and Propofol; Fentanyl and Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-12-15
    Completion
    2021-12-31
    Enrolment
    355

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnalgesia
    InterventionButorphanol and Propofol; Fentanyl and Propofol
    PhasePhase 4
    Registry statusUnknown

  • Using Preoperative Anxiety Score to Determine the Precise Dose of Butorphanol for Sedation

    NCT03429179 · start 2018-03-05

    Registered record
    Registry ID
    NCT03429179
    Conditions
    Preoperative Anxiety; Precise Dose of Butorphanol
    Interventions
    Butorphanol; Physiological saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-03-05
    Completion
    2019-03-05
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreoperative Anxiety; Precise Dose of Butorphanol
    InterventionButorphanol; Physiological saline
    PhasePhase 2
    Registry statusCompleted