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AMR Drug RepurposingSmart Screeningresearch prototype

Mivacurium Chloride

FDA-approved product (solution, intravenous), marketed as Mivacron, Mivacron In Dextrose 5% In Plastic Container, Mivacurium Chloride.

Registered studies
14
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Mivacurium Chloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Mivacurium Chloride. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA53.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis39.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

14registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mivacurium Chloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mivacurium Chloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Antagonism of Neostigmine in Continuous Infusion of Mivacurium

    NCT07524959 · start 2026-05-01

    Registered record
    Registry ID
    NCT07524959
    Conditions
    Neuromuscular Blocking Agents
    Interventions
    Neostigmine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-05-01
    Completion
    2026-07-29
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blocking Agents
    InterventionNeostigmine
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Muscle Relaxant Effect and Safety of Mivacurium Chloride and Succinylcholine for Bronchoscopy

    NCT06709066 · start 2024-11-20

    Registered record
    Registry ID
    NCT06709066
    Conditions
    Anesthesia; Bronchoscopy; Muscle Relaxants
    Interventions
    mivacurium chloride; succinylcholine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2024-11-20
    Completion
    2025-12-31
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Bronchoscopy; Muscle Relaxants
    Interventionmivacurium chloride; succinylcholine
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Evaluation of Effectiveness of Two Different Doses of Mivacurium in Rapid Sequence Intubation

    NCT06072534 · start 2023-09-01

    Registered record
    Registry ID
    NCT06072534
    Conditions
    Emergencies
    Interventions
    "Mivacurium Chloride"
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-09-01
    Completion
    2024-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEmergencies
    Intervention"Mivacurium Chloride"
    PhaseNot applicable
    Registry statusUnknown

  • Mivacurium 0.2 mg/kg in Young (18 - 40 Years) and Elderly (= 80 Years) Patients

    NCT05558137 · start 2022-09-30

    Registered record
    Registry ID
    NCT05558137
    Conditions
    Onset Time of Mivacurium, Duration of Action of Mivacurium
    Interventions
    Mivacurium
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-09-30
    Completion
    2023-05-25
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOnset Time of Mivacurium, Duration of Action of Mivacurium
    InterventionMivacurium
    PhaseNot recorded
    Registry statusCompleted

  • : A Comparison of Neuromuscular Transmission in the Muscles During General Anesthesia

    NCT04845386 · start 2021-03-25

    Registered record
    Registry ID
    NCT04845386
    Conditions
    Neuromuscular Blockade
    Interventions
    TOF Cuff on arm; TOF Cuff on lower leg; TOF Scan on toe; TOF Scan on adductor pollicis; TOF Scan on corrugator supercilii
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-03-25
    Completion
    2021-06-30
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade
    InterventionTOF Cuff on arm; TOF Cuff on lower leg; TOF Scan on toe; TOF Scan on adductor pollicis +1 more
    PhaseNot recorded
    Registry statusCompleted

  • Can we Antagonize Mivacurium With Neostigmine ?

    NCT03019835 · start 2016-12

    Registered record
    Registry ID
    NCT03019835
    Conditions
    Mivacurium; Neostigmine; Residual Paralysis
    Interventions
    Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery; Spontaneous recovery
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-12
    Completion
    2017-04-22
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMivacurium; Neostigmine; Residual Paralysis
    InterventionNeostigmine (40 mcg / kg) at different time of neuromuscular block's recovery; Spontaneous recovery
    PhaseNot applicable
    Registry statusCompleted

  • Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals

    NCT02914119 · start 2016-10-01

    Registered record
    Registry ID
    NCT02914119
    Conditions
    Neuromuscular Blockade
    Interventions
    Rocuronium; Succinylcholine; Cisatracurium; Mivacurium; Objective neuromuscular monitoring (acceleromyography); Sugammadex; Neostigmine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-10-01
    Completion
    2017-06-01
    Enrolment
    30,430

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade
    InterventionRocuronium; Succinylcholine; Cisatracurium; Mivacurium +3 more
    PhaseNot recorded
    Registry statusCompleted

  • Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis

    NCT02473601 · start 2014-10

    Registered record
    Registry ID
    NCT02473601
    Conditions
    Liver Dysfunction
    Interventions
    Mivacurium Chloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2014-10
    Completion
    2015-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Dysfunction
    InterventionMivacurium Chloride
    PhasePhase 2
    Registry statusUnknown

  • Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy

    NCT01966484 · start 2013-10

    Registered record
    Registry ID
    NCT01966484
    Conditions
    Intubating Conditions; Performance With Respiratory Exercise Device; Postoperative Myalgia
    Interventions
    Succinylcholine; Mivacurium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-10
    Completion
    Not recorded
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntubating Conditions; Performance With Respiratory Exercise Device; Postoperative Myalgia
    InterventionSuccinylcholine; Mivacurium
    PhaseNot applicable
    Registry statusCompleted

  • Sex-related Differences in the Response to the Muscle Relaxant Drug Mivacurium

    NCT01906528 · start 2013-03

    Registered record
    Registry ID
    NCT01906528
    Conditions
    Muscle Relaxation; Sex
    Interventions
    Mivacurium
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-03
    Completion
    2013-07
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMuscle Relaxation; Sex
    InterventionMivacurium
    PhasePhase 1
    Registry statusCompleted

  • Effect of Deep BLock on Intraoperative Surgical Conditions

    NCT01631149 · start 2012-06

    Registered record
    Registry ID
    NCT01631149
    Conditions
    Prostate Hypertrophy; Renal Disease
    Interventions
    Surgical block (rocuronium; atracurium/mivacurium); Surgical block (rocuronium; atracurium/mivacurium)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-06
    Completion
    2013-03
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Hypertrophy; Renal Disease
    InterventionSurgical block (rocuronium; atracurium/mivacurium); Surgical block (rocuronium; atracurium/mivacurium)
    PhasePhase 4
    Registry statusCompleted

  • A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients

    NCT02117401 · start 2012-01

    Registered record
    Registry ID
    NCT02117401
    Conditions
    Efficacy and Safety of Mivacurium Chloride for Pediatric Patients
    Interventions
    mivacurium chloride; midazolam; ketamine; propofol; Remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-01
    Completion
    2013-06
    Enrolment
    1,152

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEfficacy and Safety of Mivacurium Chloride for Pediatric Patients
    Interventionmivacurium chloride; midazolam; ketamine; propofol +1 more
    PhasePhase 4
    Registry statusCompleted

  • Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation

    NCT01427985 · start 2011-06

    Registered record
    Registry ID
    NCT01427985
    Conditions
    Newborn; Preterm; Intubation
    Interventions
    Atropine, Fentanyl, Mivacurium; Atropine, Fentanyl, Mivacurium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-06
    Completion
    2012-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNewborn; Preterm; Intubation
    InterventionAtropine, Fentanyl, Mivacurium; Atropine, Fentanyl, Mivacurium
    PhasePhase 4
    Registry statusCompleted

  • Intravenous Versus Inhalational Anesthesia in Parkinson's Disease

    NCT00615472 · start 2003-10

    Registered record
    Registry ID
    NCT00615472
    Conditions
    Parkinson's Disease
    Interventions
    Isoflurane; Remifentanil; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2003-10
    Completion
    2011-04
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson's Disease
    InterventionIsoflurane; Remifentanil; Propofol
    PhaseNot applicable
    Registry statusTerminated