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AMR Drug RepurposingSmart Screeningresearch prototype

Amiodarone Hydrochloride

FDA-approved product (tablet, oral), marketed as Amiodarone Hydrochloride, Cordarone, Nexterone and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Amiodarone Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiac arrhythmia
  • Ventricular arrhythmia
  • Ventricular fibrillation
  • Ventricular tachycardia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiarrhythmics, class iii
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli33.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae21.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis56.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Amiodarone Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Amiodarone Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Pharmacological Intervention to Prevent NOAF After TAVR

    NCT07519161 · start 2026-04-07

    Registered record
    Registry ID
    NCT07519161
    Conditions
    Atrial Fibrillation
    Interventions
    Metoprolol succinate; Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-04-07
    Completion
    2030-03-31
    Enrolment
    198

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionMetoprolol succinate; Amiodarone
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Efficacy of Early Rhythm Control in AF With TR Patients

    NCT07607093 · start 2026-02-18

    Registered record
    Registry ID
    NCT07607093
    Conditions
    Atrial Fibrillation (AF); Tricuspid Regurgitation (TR)
    Interventions
    Anti-arrhythmic drugs for rhythm control; DC cardioversion, catheter ablation for rhythm control; Usual care
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2026-02-18
    Completion
    2027-02-28
    Enrolment
    5,800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation (AF); Tricuspid Regurgitation (TR)
    InterventionAnti-arrhythmic drugs for rhythm control; DC cardioversion, catheter ablation for rhythm control; Usual care
    PhaseNot recorded
    Registry statusRecruiting

  • Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE

    NCT05293080 · start 2025-11-06

    Registered record
    Registry ID
    NCT05293080
    Conditions
    Acute Ischemic Stroke; Atrial Fibrillation
    Interventions
    Medical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version); Usual care for atrial fibrillation
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2025-11-06
    Completion
    2031-09
    Enrolment
    1,746

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Ischemic Stroke; Atrial Fibrillation
    InterventionMedical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version); Usual care for atrial fibrillation
    PhasePhase 3
    Registry statusRecruiting

  • Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy Subjects

    NCT07181265 · start 2025-10-30

    Registered record
    Registry ID
    NCT07181265
    Conditions
    Autosomal Dominant Polycystic Kidney Disease (ADPKD)
    Interventions
    Amiodarone Hydrochloride Tablets; Febuxostat Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Not yet recruiting
    Start
    2025-10-30
    Completion
    2026-06-30
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutosomal Dominant Polycystic Kidney Disease (ADPKD)
    InterventionAmiodarone Hydrochloride Tablets; Febuxostat Tablets
    PhasePhase 1
    Registry statusNot yet recruiting

  • Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery

    NCT01422148 · start 2025-07

    Registered record
    Registry ID
    NCT01422148
    Conditions
    Atrial Fibrillation
    Interventions
    Amiodarone; Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2025-07
    Completion
    2028-01-24
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAmiodarone; Minocycline
    PhasePhase 2
    Registry statusNot yet recruiting

  • Circumferential Pulmonary Vein Isolation Plus Transition Zone Modification in Atrial Fibrillation Patients Without Low-Voltage Areas

    NCT06930599 · start 2025-04-09

    Registered record
    Registry ID
    NCT06930599
    Conditions
    Atrial Fibrillation (AF)
    Interventions
    Pulmonary vein isolation plus transition zone modification; Pulmonary vein isolation alone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-04-09
    Completion
    2026-10-09
    Enrolment
    162

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation (AF)
    InterventionPulmonary vein isolation plus transition zone modification; Pulmonary vein isolation alone
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Pacing of Left Bundle Branch Area and Atroventricular Node ablatIon in Patients With Symptomatic Atrial Fibrillation

    NCT06699342 · start 2025-01-27

    Registered record
    Registry ID
    NCT06699342
    Conditions
    Atrial Fibrillation (AF)
    Interventions
    Pacemaker implantation with Left bundle branch area pacing (LBBAP); Atrioventricular node ablation (AVNA); Pharmacologic therapy optimized for Atrial Fibrillation management
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-01-27
    Completion
    2027-12-31
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation (AF)
    InterventionPacemaker implantation with Left bundle branch area pacing (LBBAP); Atrioventricular node ablation (AVNA); Pharmacologic therapy optimized for Atrial Fibrillation management
    PhaseNot applicable
    Registry statusRecruiting

  • CAB Versus Medical Therapy in Patients With AF and HF With Different EF Categories

    NCT05364866 · start 2022-05-01

    Registered record
    Registry ID
    NCT05364866
    Conditions
    Cardiovascular Diseases
    Interventions
    Antiarrhythmic drug Therapy; cryoballoon ablation
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-05-01
    Completion
    2024-12-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Diseases
    InterventionAntiarrhythmic drug Therapy; cryoballoon ablation
    PhaseNot recorded
    Registry statusUnknown

  • Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation

    NCT04392921 · start 2022-03-07

    Registered record
    Registry ID
    NCT04392921
    Conditions
    Atrial Fibrillation
    Interventions
    Amiodarone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-03-07
    Completion
    2024-04
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAmiodarone; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study

    NCT04594746 · start 2022-02-03

    Registered record
    Registry ID
    NCT04594746
    Conditions
    Atrial Fibrillation
    Interventions
    Amiodarone Hydrochloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2022-02-03
    Completion
    2026-01-20
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAmiodarone Hydrochloride; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Refralon Versus Amiodarone for Cardioversion of Paroxysmal Fibrillation and Atrial Flutter

    NCT05445297 · start 2022-01-26

    Registered record
    Registry ID
    NCT05445297
    Conditions
    Atrial Fibrillation Paroxysmal
    Interventions
    Pharmacological cardioversion with Amiodarone; Pharmacological cardioversion with Refralon
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-01-26
    Completion
    2023-06-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation Paroxysmal
    InterventionPharmacological cardioversion with Amiodarone; Pharmacological cardioversion with Refralon
    PhasePhase 4
    Registry statusCompleted

  • Catgut Embedding in Acupoints on Treating Persistent Atrial Fibrillation After Catheter Ablation

    NCT05125042 · start 2021-12-01

    Registered record
    Registry ID
    NCT05125042
    Conditions
    Persistent Atrial Fibrillation
    Interventions
    Amiodarone hydrochloride tablet + acupoint catgut embedding; Amiodarone hydrochloride tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-12-01
    Completion
    2023-12-20
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPersistent Atrial Fibrillation
    InterventionAmiodarone hydrochloride tablet + acupoint catgut embedding; Amiodarone hydrochloride tablet
    PhaseNot applicable
    Registry statusUnknown

  • Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation

    NCT04942834 · start 2021-10-01

    Registered record
    Registry ID
    NCT04942834
    Conditions
    Atrial Fibrillation, Persistent; Arrhythmias, Cardiac
    Interventions
    Antiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone; cryoballoon ablation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-10-01
    Completion
    2025-08-23
    Enrolment
    320

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation, Persistent; Arrhythmias, Cardiac
    InterventionAntiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone; cryoballoon ablation
    PhaseNot applicable
    Registry statusCompleted

  • Systematic Review and Meta-Analysis of Multaq® for Safety in Atrial Fibrillation

    NCT05279833 · start 2021-09-24

    Registered record
    Registry ID
    NCT05279833
    Conditions
    Atrial Fibrillation
    Interventions
    dronedarone; sotalol
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-09-24
    Completion
    2022-03-31
    Enrolment
    87,810

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    Interventiondronedarone; sotalol
    PhaseNot recorded
    Registry statusCompleted

  • Prophylactic Amiodarone for Shockable Cardiac Arrest

    NCT04845607 · start 2021-04-01

    Registered record
    Registry ID
    NCT04845607
    Conditions
    Cardiac Arrest; Ventricular Arrythmia
    Interventions
    Amiodarone Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2021-04-01
    Completion
    2023-02-28
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiac Arrest; Ventricular Arrythmia
    InterventionAmiodarone Injection
    PhasePhase 3
    Registry statusUnknown