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AMR Drug RepurposingSmart Screeningresearch prototype

Quinapril Hydrochloride

FDA-approved product (tablet, oral), marketed as Accupril, Quinapril Hydrochloride.

Registered studies
33
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Quinapril Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Diabetes mellitus
  • Heart failure
  • Hypertension
  • Kidney failure
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA35.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli33.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae15.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis62.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

33registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Quinapril Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Quinapril Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)

    NCT07547878 · start 2026-04-30

    Registered record
    Registry ID
    NCT07547878
    Conditions
    Chronic Kidney Disease; Type 2 Diabetes
    Interventions
    Finerenone; Semaglutide; Lotensin; Capoten; Enalapril; Monopril; Lisinopril; Univasc; Aceon; Accupril; Altace; Mavik; Edarbi; Atacand; Avapro; Cozaar; Benicar; Micardis; Diovan; Invokana; Farxiga; Jardiance; Ertugliflozin; Brenzavvy; Sotagliflozin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-04-30
    Completion
    2029-03-31
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease; Type 2 Diabetes
    InterventionFinerenone; Semaglutide; Lotensin; Capoten +21 more
    PhasePhase 4
    Registry statusNot yet recruiting

  • Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study

    NCT07262710 · start 2025-12-01

    Registered record
    Registry ID
    NCT07262710
    Conditions
    Post-stroke Pneumonia
    Interventions
    angiotensin converting enzyme inhibitors; Calcium Channel Blockers; Angiotensin Receptor Blockers
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-12-01
    Completion
    2026-08-19
    Enrolment
    13,656

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-stroke Pneumonia
    Interventionangiotensin converting enzyme inhibitors; Calcium Channel Blockers; Angiotensin Receptor Blockers
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Impact of Antihypertensive Therapy on Recurrence Risk of Ovarian Cancer for Bevacizumab-associated Hypertension

    NCT06515678 · start 2024-05-20

    Registered record
    Registry ID
    NCT06515678
    Conditions
    Ovarian Cancer; Antiangiogenic-Associated Hypertension; Adjuvant Bevacizumab; Hypertension
    Interventions
    arm A - angiotensin converting enzyme inhibitors (ACEi); arm B - calcium channel blockers (CCBs); arm R - angiotensin receptor blockers ARB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-05-20
    Completion
    2024-08-31
    Enrolment
    9,464

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Cancer; Antiangiogenic-Associated Hypertension; Adjuvant Bevacizumab; Hypertension
    Interventionarm A - angiotensin converting enzyme inhibitors (ACEi); arm B - calcium channel blockers (CCBs); arm R - angiotensin receptor blockers ARB
    PhaseNot recorded
    Registry statusUnknown

  • Effect of Sacubitril/Valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: A Real World Study

    NCT05498675 · start 2021-09-01

    Registered record
    Registry ID
    NCT05498675
    Conditions
    Sacubitril/Valsartan; Hypertension; Obesity
    Interventions
    Sacubitril / Valsartan Oral Tablet [Entresto]; ACEI/ARB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2021-09-01
    Completion
    2027-06-30
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSacubitril/Valsartan; Hypertension; Obesity
    InterventionSacubitril / Valsartan Oral Tablet [Entresto]; ACEI/ARB
    PhaseNot recorded
    Registry statusRecruiting

  • Coronavirus (COVID-19) ACEi/ARB Investigation

    NCT04330300 · start 2020-04-30

    Registered record
    Registry ID
    NCT04330300
    Conditions
    Hypertension; COVID-19
    Interventions
    Thiazide or Thiazide-like diuretics; Calcium Channel Blockers; ACE inhibitor; Angiotensin receptor blocker
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Suspended
    Start
    2020-04-30
    Completion
    2021-12-01
    Enrolment
    2,414

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; COVID-19
    InterventionThiazide or Thiazide-like diuretics; Calcium Channel Blockers; ACE inhibitor; Angiotensin receptor blocker
    PhasePhase 4
    Registry statusSuspended

  • ACEI or ARB and COVID-19 Severity and Mortality in US Veterans

    NCT04467931 · start 2020-01-19

    Registered record
    Registry ID
    NCT04467931
    Conditions
    Hypertension; COVID
    Interventions
    ACEI/ARB; Non-ACEI/ARB; ACEI; ARB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-01-19
    Completion
    2020-12-31
    Enrolment
    22,213

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; COVID
    InterventionACEI/ARB; Non-ACEI/ARB; ACEI; ARB
    PhaseNot recorded
    Registry statusCompleted

  • Diabetic Autonomic Neuropathy and Left Ventricular Function

    NCT05713396 · start 2017-01-01

    Registered record
    Registry ID
    NCT05713396
    Conditions
    Diabetes Mellitus
    Interventions
    Quinapril; Losartan; Quinapril + Losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-01-01
    Completion
    2022-06-01
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus
    InterventionQuinapril; Losartan; Quinapril + Losartan
    PhasePhase 4
    Registry statusCompleted

  • NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

    NCT02817360 · start 2016-02

    Registered record
    Registry ID
    NCT02817360
    Conditions
    Heart Diseases; Diabetes Mellitus, Type 2
    Interventions
    RAS-antagonist and beta-blocker up-to maximal dosages; RAS-antagonist and beta-blocker none or at stable dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2016-02
    Completion
    2026-12
    Enrolment
    2,400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Diseases; Diabetes Mellitus, Type 2
    InterventionRAS-antagonist and beta-blocker up-to maximal dosages; RAS-antagonist and beta-blocker none or at stable dose
    PhasePhase 4
    Registry statusRecruiting

  • Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery

    NCT01669434 · start 2015-06-01

    Registered record
    Registry ID
    NCT01669434
    Conditions
    Hypotension on Induction
    Interventions
    ACEI continuation; ACEI omission
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-06-01
    Completion
    2016-12-01
    Enrolment
    291

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypotension on Induction
    InterventionACEI continuation; ACEI omission
    PhasePhase 4
    Registry statusCompleted

  • ACE-Inhibitor Effects on Total Hip and Knee Arthroplasty Patients

    NCT01867047 · start 2013-06

    Registered record
    Registry ID
    NCT01867047
    Conditions
    Adverse Effects of Angiotensin-converting-enzyme Inhibitors; Hypotension
    Interventions
    ACE-I Cessation group; ACE-I Continuation group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2013-06
    Completion
    2016-06-24
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdverse Effects of Angiotensin-converting-enzyme Inhibitors; Hypotension
    InterventionACE-I Cessation group; ACE-I Continuation group
    PhaseNot applicable
    Registry statusTerminated

  • Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics

    NCT01715584 · start 2012-07

    Registered record
    Registry ID
    NCT01715584
    Conditions
    Hypertension
    Interventions
    Sevoflurane/oxygen/air/nitrous oxide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-07
    Completion
    2019-12-31
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionSevoflurane/oxygen/air/nitrous oxide
    PhasePhase 4
    Registry statusUnknown

  • Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF

    NCT00438113 · start 2009-12

    Registered record
    Registry ID
    NCT00438113
    Conditions
    Atrial Fibrillation
    Interventions
    Aggressive Blood Pressure control
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-12
    Completion
    2016-09
    Enrolment
    184

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAggressive Blood Pressure control
    PhasePhase 4
    Registry statusCompleted

  • A Non Interventional Study To Asses The Safety, Effectiveness And Tolerability Of Quinapril (Acupil®) In An Indian Population

    NCT00930722 · start 2009-06

    Registered record
    Registry ID
    NCT00930722
    Conditions
    Hypertension
    Interventions
    quinapril
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-06
    Completion
    2010-06
    Enrolment
    329

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionquinapril
    PhaseNot recorded
    Registry statusCompleted

  • Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial

    NCT01581476 · start 2009-01

    Registered record
    Registry ID
    NCT01581476
    Conditions
    Type 1 Diabetes
    Interventions
    Statin; ACE inhibitor; Placebo; Combination therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-01
    Completion
    2017-06
    Enrolment
    443

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 1 Diabetes
    InterventionStatin; ACE inhibitor; Placebo; Combination therapy
    PhasePhase 3
    Registry statusCompleted

  • Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment

    NCT00741585 · start 2008-09-01

    Registered record
    Registry ID
    NCT00741585
    Conditions
    Essential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    Interventions
    Any antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-09-01
    Completion
    2018-06-30
    Enrolment
    21,983

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    InterventionAny antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    PhasePhase 4
    Registry statusCompleted