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AMR Drug RepurposingSmart Screeningresearch prototype

Clevidipine

FDA-approved product (emulsion, intravenous), marketed as Cleviprex.

Registered studies
34
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Clevidipine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Dihydropyridine derivatives
FDA pharmacologic class
Dihydropyridine Calcium Channel Blocker FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis48.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

34registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Clevidipine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clevidipine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion

    NCT01645111 · start 2012-06

    Registered record
    Registry ID
    NCT01645111
    Conditions
    Neuromuscular Scoliosis
    Interventions
    Clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2012-06
    Completion
    2013-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Scoliosis
    InterventionClevidipine
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Pre and or Post Operative Blood Pressure Control With Clevidipine (Cleviprexm Medicines Company) in Aortic Aneurysm / Dissection

    NCT01480531 · start 2011-12

    Registered record
    Registry ID
    NCT01480531
    Conditions
    Aorta Aneurysm; Dissection of Aorta
    Interventions
    Clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2011-12
    Completion
    2012-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAorta Aneurysm; Dissection of Aorta
    InterventionClevidipine
    PhaseNot applicable
    Registry statusWithdrawn

  • The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients

    NCT01526876 · start 2011-11

    Registered record
    Registry ID
    NCT01526876
    Conditions
    Hypertension
    Interventions
    clevidipine butyrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2011-11
    Completion
    2012-12-19
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionclevidipine butyrate
    PhasePhase 4
    Registry statusWithdrawn

  • The Energy Dose Study

    NCT01369147 · start 2011-07

    Registered record
    Registry ID
    NCT01369147
    Conditions
    Critical Illness
    Interventions
    Parenteral Nutrition; Propofol; Clevidipine; Dextrose-containing IV Fluids; Enteral feeding
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-07
    Completion
    2014-12-02
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCritical Illness
    InterventionParenteral Nutrition; Propofol; Clevidipine; Dextrose-containing IV Fluids +1 more
    PhasePhase 2
    Registry statusTerminated

  • The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy

    NCT01042574 · start 2010-05

    Registered record
    Registry ID
    NCT01042574
    Conditions
    Hypertension; Intracranial Hemorrhage; Subarachnoid Hemorrhage
    Interventions
    Clevidipine butyrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2010-05
    Completion
    2010-12-31
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Intracranial Hemorrhage; Subarachnoid Hemorrhage
    InterventionClevidipine butyrate
    PhasePhase 4
    Registry statusWithdrawn

  • The Evaluation of Clevidipine in Patients Requiring ICP Monitoring and IV Antihypertensive Therapy

    NCT01910532 · start 2010-04

    Registered record
    Registry ID
    NCT01910532
    Conditions
    Hypertension
    Interventions
    Clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2010-04
    Completion
    2012-11
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionClevidipine
    PhasePhase 4
    Registry statusWithdrawn

  • A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT)

    NCT01033370 · start 2009-11

    Registered record
    Registry ID
    NCT01033370
    Conditions
    Aortic Aneurysm; Aortic Disease
    Interventions
    clevidipine.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-11
    Completion
    2012-08
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Aneurysm; Aortic Disease
    Interventionclevidipine.
    PhasePhase 4
    Registry statusTerminated

  • Clevidipine for Vasoreactivity Evaluation of the Pulmonary Arterial Bed

    NCT01121458 · start 2009-09

    Registered record
    Registry ID
    NCT01121458
    Conditions
    Hypertension, Pulmonary
    Interventions
    Clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    2013-04
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension, Pulmonary
    InterventionClevidipine
    PhasePhase 4
    Registry statusCompleted

  • A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients

    NCT00952081 · start 2009-07

    Registered record
    Registry ID
    NCT00952081
    Conditions
    Hypertension; Brain Tumor; Epilepsy
    Interventions
    Clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2010-02
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Brain Tumor; Epilepsy
    InterventionClevidipine
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage

    NCT00978822 · start 2009-06

    Registered record
    Registry ID
    NCT00978822
    Conditions
    Subarachnoid Hemorrhage; Hypertension
    Interventions
    Clevidipine butyrate injectable emulsion
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-06
    Completion
    2012-12
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubarachnoid Hemorrhage; Hypertension
    InterventionClevidipine butyrate injectable emulsion
    PhasePhase 2
    Registry statusTerminated

  • Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO)

    NCT00803634 · start 2008-12

    Registered record
    Registry ID
    NCT00803634
    Conditions
    Hypertension; Heart Failure
    Interventions
    Clevidipine; Standard of Care IV antihypertensive
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-12
    Completion
    2012-03
    Enrolment
    117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Heart Failure
    InterventionClevidipine; Standard of Care IV antihypertensive
    PhasePhase 3
    Registry statusCompleted

  • Clevidipine Bolus Administration in the Treatment of Hypertensive Patients Undergoing Cardiac Surgery (SPRINT)

    NCT00799604 · start 2008-11

    Registered record
    Registry ID
    NCT00799604
    Conditions
    Hypertension
    Interventions
    clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-11
    Completion
    2009-10
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionclevidipine
    PhasePhase 2
    Registry statusCompleted

  • Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE)

    NCT00666328 · start 2008-06

    Registered record
    Registry ID
    NCT00666328
    Conditions
    Hypertension; Hemorrhage
    Interventions
    clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-06
    Completion
    2010-04
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Hemorrhage
    Interventionclevidipine
    PhasePhase 3
    Registry statusCompleted

  • Clevidipine in the Treatment of Patients With Severe Hypertension (VELOCITY)

    NCT00369837 · start 2006-09

    Registered record
    Registry ID
    NCT00369837
    Conditions
    Hypertension
    Interventions
    clevidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-02
    Enrolment
    131

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionclevidipine
    PhasePhase 3
    Registry statusCompleted

  • Clevidipine in the Perioperative Treatment of Hypertension (ECLISPE-SNP)

    NCT00093912 · start 2004-06

    Registered record
    Registry ID
    NCT00093912
    Conditions
    Hypertension
    Interventions
    clevidipine; sodium nitroprusside
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-06
    Completion
    2006-11
    Enrolment
    739

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionclevidipine; sodium nitroprusside
    PhasePhase 3
    Registry statusCompleted