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AMR Drug RepurposingSmart Screeningresearch prototype

Tromethamine

FDA-approved product (solution, injection), marketed as Tham, Tromethamine.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Tromethamine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acidosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Solutions affecting the electrolyte balance; Other i.v. solution additives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Tromethamine, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA7.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli8.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae4.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis9.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tromethamine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tromethamine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients

    NCT07424625 · start 2026-09-14

    Registered record
    Registry ID
    NCT07424625
    Conditions
    Metabolic Acidosis
    Interventions
    Sodium bicarbonate; Tris-hydroxymethyl Aminomethane
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-09-14
    Completion
    2028-06
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Acidosis
    InterventionSodium bicarbonate; Tris-hydroxymethyl Aminomethane
    PhasePhase 4
    Registry statusRecruiting

  • Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty

    NCT07577869 · start 2026-06-02

    Registered record
    Registry ID
    NCT07577869
    Conditions
    Postoperative Pain Following Knee Arthroplasty; Total Knee Arthroplasty
    Interventions
    Procedure: Biceps Femoris Short Head Block; Procedure: Spinal Anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-06-02
    Completion
    2027-07-02
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain Following Knee Arthroplasty; Total Knee Arthroplasty
    InterventionProcedure: Biceps Femoris Short Head Block; Procedure: Spinal Anesthesia
    PhaseNot applicable
    Registry statusRecruiting

  • Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin

    NCT07047040 · start 2025-08-15

    Registered record
    Registry ID
    NCT07047040
    Conditions
    Pain, Postoperative; Osteoarthritis, Knee
    Interventions
    Ketorolac Tromethamine 30 MG/ML Prefilled Syringe; Gabapentin; Empty Medication Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Not yet recruiting
    Start
    2025-08-15
    Completion
    2027-12-30
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative; Osteoarthritis, Knee
    InterventionKetorolac Tromethamine 30 MG/ML Prefilled Syringe; Gabapentin; Empty Medication Capsules
    PhasePhase 2 / Phase 3
    Registry statusNot yet recruiting

  • Clinical Study of the Effectiveness, Tolerability and Safety of the Drug "Anti-spike, Gel, 100 g in Bottles in Package No. 1" Produced by the Republican Unitary Enterprise "Unitekhprom BSU", With a Single Intraperitoneal Use After Surgery in Adult Patients With Acute Phlegmonous Appendicitis

    NCT06365632 · start 2025-03-19

    Registered record
    Registry ID
    NCT06365632
    Conditions
    Abdominal Adhesions
    Interventions
    Antispike gel, 100 g in a flask, produced by UNITEHPROM BSU, Republic of Belarus; antegrade appendectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2025-03-19
    Completion
    2025-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdominal Adhesions
    InterventionAntispike gel, 100 g in a flask, produced by UNITEHPROM BSU, Republic of Belarus; antegrade appendectomy
    PhasePhase 2
    Registry statusActive not recruiting

  • Dexketoprofen Dosage According to Chronotherapy

    NCT05176158 · start 2024-11-01

    Registered record
    Registry ID
    NCT05176158
    Conditions
    Tooth, Impacted; Trismus; Pain; Inflammatory Response
    Interventions
    Dexketoprofen 25 MG; Dexketoprofen 25 MG
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-11-01
    Completion
    2024-11-01
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTooth, Impacted; Trismus; Pain; Inflammatory Response
    InterventionDexketoprofen 25 MG; Dexketoprofen 25 MG
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Superior Hypogastric Plexus Block and Peritoneal Bupivacaine in Pain Management

    NCT06954896 · start 2024-07-01

    Registered record
    Registry ID
    NCT06954896
    Conditions
    Superior Hypogastric Plexus Block; Intraperitoneal Bupivacaine
    Interventions
    Bupivacain; Dexketoprofen (KETAVEL 50 mg/2 ml); Intraperitoneal Bupivacaine spray
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2024-07-01
    Completion
    2025-02-20
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSuperior Hypogastric Plexus Block; Intraperitoneal Bupivacaine
    InterventionBupivacain; Dexketoprofen (KETAVEL 50 mg/2 ml); Intraperitoneal Bupivacaine spray
    PhaseNot recorded
    Registry statusCompleted

  • Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement

    NCT05875571 · start 2024-02-05

    Registered record
    Registry ID
    NCT05875571
    Conditions
    IUD; Healthy Female; Contraception; IUD Insertion Complication
    Interventions
    Ketorolac; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2024-02-05
    Completion
    2025-06
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIUD; Healthy Female; Contraception; IUD Insertion Complication
    InterventionKetorolac; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Naproxen and Lidocaine Gel Combination for Rib Fracture

    NCT07706036 · start 2024-01-01

    Registered record
    Registry ID
    NCT07706036
    Conditions
    Thorax; Fracture; Rib Fracture; Pain Management
    Interventions
    A gel combination containing 10% naproxen and 5% lidocaine; Dexketoprofen trometamol 50 mg IV
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-01-01
    Completion
    2024-07-02
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThorax; Fracture; Rib Fracture; Pain Management
    InterventionA gel combination containing 10% naproxen and 5% lidocaine; Dexketoprofen trometamol 50 mg IV
    PhaseNot applicable
    Registry statusCompleted

  • The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery

    NCT05591105 · start 2023-06-15

    Registered record
    Registry ID
    NCT05591105
    Conditions
    Pharmacological Action; Post Operative Pain; Opioid Use; Obesity, Morbid; Anesthesia Morbidity
    Interventions
    Control Group; Placebo
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2023-06-15
    Completion
    2024-01-31
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacological Action; Post Operative Pain; Opioid Use; Obesity, Morbid +1 more
    InterventionControl Group; Placebo
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryoirrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial.

    NCT04733326 · start 2021-09-01

    Registered record
    Registry ID
    NCT04733326
    Conditions
    Post-operative Pain
    Interventions
    Ketorolac Tromethamine; Cryotherapy; Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2021-09-01
    Completion
    2023-03-01
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-operative Pain
    InterventionKetorolac Tromethamine; Cryotherapy; Saline
    PhasePhase 1
    Registry statusCompleted

  • Safety, Tolerability and Pharmacokinetics of Felbinac Trometamol Eye Drops

    NCT05085106 · start 2020-10-21

    Registered record
    Registry ID
    NCT05085106
    Conditions
    Healthy
    Interventions
    Felbinac trometamol eye drop; Placebo eye drop
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2020-10-21
    Completion
    2021-12-31
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionFelbinac trometamol eye drop; Placebo eye drop
    PhasePhase 1
    Registry statusUnknown

  • Analysis of Clinical Effect of Subanesthetic Dose of Esketamine Combined With Hip Capsule Peripheral Nerve Block in Elderly Patients Undergoing Total Hip Arthroplasty

    NCT05602428 · start 2020-01-01

    Registered record
    Registry ID
    NCT05602428
    Conditions
    Total Hip Arthroplasty
    Interventions
    esketamine sub-anesthetic,; esketamine sub-anesthetic; esketamine sub-anesthetic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-01-01
    Completion
    2021-05-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTotal Hip Arthroplasty
    Interventionesketamine sub-anesthetic,; esketamine sub-anesthetic; esketamine sub-anesthetic
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Efficacy of Fosfomycin Trometamol Per os in the Treatment of Documented Male Urinary Tract Infections With ESBL-producing Enterobacteriaceae With ESBL Producing Enterobacteriaceae and Resistance Associated With Fluoroquinolones and Cotrimoxazole (FOSF'HOM)

    NCT03868969 · start 2019-04

    Registered record
    Registry ID
    NCT03868969
    Conditions
    Urinary Tract Infections
    Interventions
    Fosfomycin Oral Suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2019-04
    Completion
    2021-09
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionFosfomycin Oral Suspension
    PhasePhase 2
    Registry statusUnknown

  • A Phase Ⅱ Clinical Study Trial of Felbinac Trometamol Injection in China

    NCT03872830 · start 2019-03-27

    Registered record
    Registry ID
    NCT03872830
    Conditions
    Pain
    Interventions
    Felbinac Trometamol Injection; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-03-27
    Completion
    2019-12-05
    Enrolment
    165

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionFelbinac Trometamol Injection; Placebos
    PhasePhase 2
    Registry statusCompleted

  • Post-Op Pain Control for Prophylactic Intramedullary Nailing.

    NCT03823534 · start 2019-02-20

    Registered record
    Registry ID
    NCT03823534
    Conditions
    Bone Metastases; Lymphoma; Multiple Myeloma; Opioid Use; Pain
    Interventions
    Ketorolac; Normal saline; Acetaminophen; Oxycodone Acetaminophen; Morphine; Hydrocodone/Acetaminophen; Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2019-02-20
    Completion
    2027-03-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBone Metastases; Lymphoma; Multiple Myeloma; Opioid Use +1 more
    InterventionKetorolac; Normal saline; Acetaminophen; Oxycodone Acetaminophen +3 more
    PhasePhase 3
    Registry statusRecruiting