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AMR Drug RepurposingSmart Screeningresearch prototype

Ciclesonide

FDA-approved product (aerosol, metered, inhalation), marketed as Alvesco, Omnaris, Zetonna.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Ciclesonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Allergic rhinitis
  • Asthma
  • Nasal congestion
  • Rhinitis, Allergic, Perennial
  • Seasonal allergic rhinitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA60.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ciclesonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-9.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ciclesonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Cost-effectiveness Study of Beclomethasone Versus Ciclesonide as Controller Medications in Pediatric Asthma

    NCT01333800 · start 2010-07

    Registered record
    Registry ID
    NCT01333800
    Conditions
    Asthma
    Interventions
    Beclomethasone; Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-07
    Completion
    2010-12
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionBeclomethasone; Ciclesonide
    PhasePhase 4
    Registry statusCompleted

  • ATEM (Alvesco Non-interventional Study)

    NCT01147224 · start 2010-03

    Registered record
    Registry ID
    NCT01147224
    Conditions
    Asthma; Allergy
    Interventions
    Alvesco
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-03
    Completion
    2011-08
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma; Allergy
    InterventionAlvesco
    PhaseNot recorded
    Registry statusCompleted

  • Study of the Effects of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol on Hypothalamic-Pituitary-Adrenal (HPA) Axis

    NCT01033825 · start 2010-01

    Registered record
    Registry ID
    NCT01033825
    Conditions
    Perennial Allergic Rhinitis
    Interventions
    Ciclesonide HFA Nasal Aerosol 320 mcg; Ciclesonide HFA Nasal Aerosol 160 mcg; HFA Nasal Aerosol placebo; Ciclesonide Aqueous Nasal Spray 200 mcg; AQ Nasal Spray Placebo; Placebo plus Dexamethasone HFA; Placebo AQ plus Dexamethasone 6 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-01
    Completion
    2010-05
    Enrolment
    310

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerennial Allergic Rhinitis
    InterventionCiclesonide HFA Nasal Aerosol 320 mcg; Ciclesonide HFA Nasal Aerosol 160 mcg; HFA Nasal Aerosol placebo; Ciclesonide Aqueous Nasal Spray 200 mcg +3 more
    PhasePhase 3
    Registry statusCompleted

  • Small Particle Steroids in Refractory Asthma

    NCT01171365 · start 2010-01

    Registered record
    Registry ID
    NCT01171365
    Conditions
    Asthma
    Interventions
    Ciclesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-01
    Completion
    2013-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Usefulness of Exhaled Breath Condensate for Evaluation of Markers of Airway Inflammation in Children With Asthma

    NCT00961155 · start 2009-08

    Registered record
    Registry ID
    NCT00961155
    Conditions
    Asthma
    Interventions
    cyklezonid; montelukast sodium; placebo; formoterol 12 mcg twice daily
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2009-08
    Completion
    2014-06
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    Interventioncyklezonid; montelukast sodium; placebo; formoterol 12 mcg twice daily
    PhasePhase 2
    Registry statusUnknown

  • Clinical Trial to Assess the Efficacy and Safety of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol for the Treatment of Seasonal Allergic Rhinitis

    NCT00790023 · start 2008-11

    Registered record
    Registry ID
    NCT00790023
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    80 mcg Ciclesonide; 160 mcg Ciclesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-11
    Completion
    2009-02
    Enrolment
    707

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    Intervention80 mcg Ciclesonide; 160 mcg Ciclesonide; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Ciclesonide for the Treatment of Airway Hyperresponsiveness

    NCT00826969 · start 2008-09

    Registered record
    Registry ID
    NCT00826969
    Conditions
    Asthma
    Interventions
    Ciclesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-09
    Completion
    2011-10
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Ciclesonide During the Cold Season in Patients Older Than 12 Years With Persistent Asthma

    NCT00608218 · start 2008-01

    Registered record
    Registry ID
    NCT00608218
    Conditions
    Asthma
    Interventions
    Ciclesonide
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-08
    Enrolment
    2,100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide
    PhaseNot recorded
    Registry statusCompleted

  • Efficacy and Safety Comparison of Steroid or Placebo in Combination With Salmeterol and Tiotropium in COPD

    NCT00535366 · start 2007-10

    Registered record
    Registry ID
    NCT00535366
    Conditions
    Pulmonary Disease, Chronic Obstructive
    Interventions
    Tiotropium; Salmeterol; Fluticasone; Ciclesonide low; Ciclesonide high; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-10
    Completion
    Not recorded
    Enrolment
    103

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Disease, Chronic Obstructive
    InterventionTiotropium; Salmeterol; Fluticasone; Ciclesonide low +2 more
    PhasePhase 2
    Registry statusCompleted

  • The Mannitol-Asthma-Ciclesonide-Study

    NCT03839433 · start 2007-06

    Registered record
    Registry ID
    NCT03839433
    Conditions
    Asthma, Bronchial
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-06
    Completion
    2008-08
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma, Bronchial
    InterventionCiclesonide
    PhasePhase 4
    Registry statusCompleted

  • Comparison Between Systemic Exposure to Ciclesonide Nasal Spray, Ciclesonide HFA Nasal Aerosol and Orally Inhaled Ciclesonide (BY9010/M1-422)

    NCT00458835 · start 2007-04

    Registered record
    Registry ID
    NCT00458835
    Conditions
    Allergic Rhinitis
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-04
    Completion
    2008-04
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionCiclesonide
    PhasePhase 4
    Registry statusCompleted

  • Asthma Care With Alvesco® (Ciclesonide) in Primary Care in Adults - The ACCEPT-study (BY9010/CA-102)

    NCT00404547 · start 2006-11

    Registered record
    Registry ID
    NCT00404547
    Conditions
    Asthma
    Interventions
    Ciclesonide; Usual Care Inhaled Glucocorticosteroids
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-11
    Completion
    2008-12
    Enrolment
    1,121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide; Usual Care Inhaled Glucocorticosteroids
    PhasePhase 4
    Registry statusCompleted

  • Evaluation of Traditional Paper Symptom Diary vs. the VOCEL Mobile Diary

    NCT00367263 · start 2006-10

    Registered record
    Registry ID
    NCT00367263
    Conditions
    Asthma
    Interventions
    Alvesco (Ciclesonide) 160 ug/day
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-10
    Completion
    2006-11
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionAlvesco (Ciclesonide) 160 ug/day
    PhaseNot applicable
    Registry statusCompleted

  • A Study of Ciclesonide Nasal Spray in Patients 18 Years and Older With Seasonal Allergic Rhinitis (BY9010/M1-413)

    NCT00384475 · start 2006-10

    Registered record
    Registry ID
    NCT00384475
    Conditions
    Rhinitis, Allergic, Seasonal; Hay Fever
    Interventions
    Ciclesonide Nasal Spray
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-10
    Completion
    2007-01
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Seasonal; Hay Fever
    InterventionCiclesonide Nasal Spray
    PhasePhase 3
    Registry statusCompleted

  • A Comparative Study of Inhaled Ciclesonide Versus Placebo in Children (6-11 Years) With Asthma

    NCT00384189 · start 2006-09

    Registered record
    Registry ID
    NCT00384189
    Conditions
    Asthma
    Interventions
    Ciclesonide; Placebo; Salbutamol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2008-08
    Enrolment
    1,080

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide; Placebo; Salbutamol
    PhasePhase 3
    Registry statusCompleted