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AMR Drug RepurposingSmart Screeningresearch prototype

Ergocalciferol

FDA-approved product (capsule, oral), marketed as Deltalin, Drisdol, Ergocalciferol and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Ergocalciferol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hypoparathyroidism
  • Hypophosphatemia
  • Hypophosphatemic rickets

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin d and analogues
FDA pharmacologic class
Provitamin D2 Compound FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli24.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis30.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ergocalciferol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ergocalciferol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Vitamin D in Post-Stroke Cognitive Impairment

    NCT07767214 · start 2026-01-01

    Registered record
    Registry ID
    NCT07767214
    Conditions
    Post-Stroke Cognitive Impairment (PSCI)
    Interventions
    Vitamin D2 capsules; Placebo Soft Capsules (Vitamin D₂-matched placebo)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2026-01-01
    Completion
    2028-06-01
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-Stroke Cognitive Impairment (PSCI)
    InterventionVitamin D2 capsules; Placebo Soft Capsules (Vitamin D₂-matched placebo)
    PhaseNot applicable
    Registry statusActive not recruiting

  • Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters

    NCT06969716 · start 2025-05-01

    Registered record
    Registry ID
    NCT06969716
    Conditions
    Fibromyalgia; Old Age; Debility
    Interventions
    Detailed geriatric assessment
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2025-05-01
    Completion
    2026-03-03
    Enrolment
    420

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFibromyalgia; Old Age; Debility
    InterventionDetailed geriatric assessment
    PhaseNot recorded
    Registry statusCompleted

  • Effect of Vitamin D Supplementation on the Efficacy and Adverse Effects of Neoadjuvant Therapy in Patients with Breast Cancer

    NCT06642428 · start 2024-10-18

    Registered record
    Registry ID
    NCT06642428
    Conditions
    Vitamin D; Neoadjuvant Therapy; Breast Cancer; Adverse Reaction; Efficacy; Chemotherapy
    Interventions
    Neoadjuvant therapy + vitamin D2; Neoadjuvant therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-10-18
    Completion
    2026-04-30
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D; Neoadjuvant Therapy; Breast Cancer; Adverse Reaction +2 more
    InterventionNeoadjuvant therapy + vitamin D2; Neoadjuvant therapy
    PhaseNot applicable
    Registry statusRecruiting

  • An Investigation of a Multi-Function Skincare Product to Improve Aging, Eczema, and Acne Outcomes

    NCT05873933 · start 2024-07-01

    Registered record
    Registry ID
    NCT05873933
    Conditions
    Acne; Eczema; Skin Aging
    Interventions
    Hemptress Oil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2024-07-01
    Completion
    2024-11-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne; Eczema; Skin Aging
    InterventionHemptress Oil
    PhaseNot applicable
    Registry statusWithdrawn

  • Oral or Intra Muscular Vitamin D2 Vs Oral or Intra Muscular Vitamin D3 in Treatment of Vitamin D Deficiency

    NCT06618365 · start 2023-02-02

    Registered record
    Registry ID
    NCT06618365
    Conditions
    Vitamin D Deficiency
    Interventions
    Vitamin D Deficiency
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2023-02-02
    Completion
    2025-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionVitamin D Deficiency
    PhaseNot applicable
    Registry statusActive not recruiting

  • Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy

    NCT05259527 · start 2022-12-19

    Registered record
    Registry ID
    NCT05259527
    Conditions
    Neuropathic Pain
    Interventions
    Ergocalciferol Capsules; Cholecalciferol Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Suspended
    Start
    2022-12-19
    Completion
    2030-03-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuropathic Pain
    InterventionErgocalciferol Capsules; Cholecalciferol Capsules
    PhasePhase 2
    Registry statusSuspended

  • Effects of Vitamin D-Enriched Mushrooms on Vitamin D Status and Immune Function and Inflammatory Status in Adults

    NCT05559112 · start 2022-12-05

    Registered record
    Registry ID
    NCT05559112
    Conditions
    Vitamin D Deficiency
    Interventions
    Vitamin D-enriched mushrooms; Study Powder
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-12-05
    Completion
    2024-04-30
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionVitamin D-enriched mushrooms; Study Powder
    PhaseNot applicable
    Registry statusCompleted

  • Vitamin D Deficiency in Adults Following a Major Burn Injury

    NCT05084248 · start 2022-09-29

    Registered record
    Registry ID
    NCT05084248
    Conditions
    Vitamin D Deficiency; Burns
    Interventions
    Ergocalciferol Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-09-29
    Completion
    2025-08-18
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Burns
    InterventionErgocalciferol Capsules
    PhasePhase 4
    Registry statusCompleted

  • Effect of Vitamin D Supplementation as Adjuvant Therapy in Neonatal Jaundice in Combination With Phototherapy

    NCT06650293 · start 2022-05-10

    Registered record
    Registry ID
    NCT06650293
    Conditions
    Neonatal Jaundice
    Interventions
    Vitamin D
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-05-10
    Completion
    2022-11-10
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeonatal Jaundice
    InterventionVitamin D
    PhaseNot applicable
    Registry statusCompleted

  • A Study on the Effects of Nutritious Mushrooms in Adults With Metabolic Syndrome

    NCT04081818 · start 2021-01-01

    Registered record
    Registry ID
    NCT04081818
    Conditions
    Metabolic Syndrome
    Interventions
    Nutritious Mushrooms
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-01-01
    Completion
    2022-03-16
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Syndrome
    InterventionNutritious Mushrooms
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Serum Calcium Level Between Preoperative Vitamin D and Non-vitamin D Regimen of Total Parathyroidectomy in End-stage Renal Failure Patients in Rajavithi Hospital

    NCT04967469 · start 2020-09-01

    Registered record
    Registry ID
    NCT04967469
    Conditions
    End Stage Renal Disease
    Interventions
    Calcitriol; Alfacalcidol 0.5 MCG Oral Capsule
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-09-01
    Completion
    2023-12-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnd Stage Renal Disease
    InterventionCalcitriol; Alfacalcidol 0.5 MCG Oral Capsule
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Ergocalciferol on Iron Metabolism in Individuals With Chronic Kidney Disease

    NCT03073369 · start 2018-01-01

    Registered record
    Registry ID
    NCT03073369
    Conditions
    CKD; Chronic Kidney Diseases; Hepcidin; Ergocalciferol; Vitamin D; Iron-deficiency; Anemia
    Interventions
    Ergocalciferol 50000 UNT; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2018-01-01
    Completion
    2018-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCKD; Chronic Kidney Diseases; Hepcidin; Ergocalciferol +3 more
    InterventionErgocalciferol 50000 UNT; Placebo
    PhasePhase 4
    Registry statusWithdrawn

  • Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes

    NCT03046927 · start 2017-10-19

    Registered record
    Registry ID
    NCT03046927
    Conditions
    Type 1 Diabetes
    Interventions
    Ergocalciferol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2017-10-19
    Completion
    2021-04-20
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 1 Diabetes
    InterventionErgocalciferol; Placebo
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients

    NCT03066817 · start 2017-07-01

    Registered record
    Registry ID
    NCT03066817
    Conditions
    Vitamin D Deficiency; Polytrauma; Orthopedic Disorder
    Interventions
    Ergocalciferol 8000 IU/ML Oral Liquid [DRISDOL]; Propylene Glycol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Suspended
    Start
    2017-07-01
    Completion
    2020-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Polytrauma; Orthopedic Disorder
    InterventionErgocalciferol 8000 IU/ML Oral Liquid [DRISDOL]; Propylene Glycol
    PhasePhase 1 / Phase 2
    Registry statusSuspended

  • Effect of Vitamin D3 Supplementation in Children From 12 to 30 Months of Age.

    NCT03544671 · start 2016-09-15

    Registered record
    Registry ID
    NCT03544671
    Conditions
    Vitamin D Deficiency; 25-Hydroxyvitamin D3 Deficiency, Selective
    Interventions
    Vitamin D
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-09-15
    Completion
    2017-12-21
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; 25-Hydroxyvitamin D3 Deficiency, Selective
    InterventionVitamin D
    PhaseNot applicable
    Registry statusCompleted