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AMR Drug RepurposingSmart Screeningresearch prototype

Menadione

FDA-approved product (tablet, oral), marketed as Menadione.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Menadione
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Vitamin k
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA3.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli14.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae4.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis59.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Menadione in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Menadione with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Risk Factors and Outcomes of Acute Venous Thromboembolism in Cirrhotic

    NCT03580577 · start 2018-09-01

    Registered record
    Registry ID
    NCT03580577
    Conditions
    Liver Cirrhosis; Venous Thromboembolism
    Interventions
    thromboelastography
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2018-09-01
    Completion
    2019-09-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Cirrhosis; Venous Thromboembolism
    Interventionthromboelastography
    PhaseNot recorded
    Registry statusUnknown

  • Treatment Pattern of NOACs (Non-vitamin K Oral Anticoagulants) in Outpatient Users in Colombian Databases

    NCT03474757 · start 2018-02-28

    Registered record
    Registry ID
    NCT03474757
    Conditions
    Atrial Fibrillation
    Interventions
    Data Collection
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-02-28
    Completion
    2018-07-30
    Enrolment
    10,528

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionData Collection
    PhaseNot recorded
    Registry statusCompleted

  • A Study to Evaluate the Effect of Multiple Doses of CC-90001 on the Pharmacokinetics of Omeprazole, Midazolam, Warfarin, Rosuvastatin, Metformin, Digoxin, and Nintedanib in Healthy Adult Subjects

    NCT03363815 · start 2017-12-04

    Registered record
    Registry ID
    NCT03363815
    Conditions
    Heathy Volunteer
    Interventions
    CC-90001; Omeprazole; Midazolam; Warfarin; Vitamin K; Rosuvastatin; Metformin; Digoxin; Nintedanib
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2017-12-04
    Completion
    2018-07-29
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeathy Volunteer
    InterventionCC-90001; Omeprazole; Midazolam; Warfarin +5 more
    PhasePhase 1
    Registry statusCompleted

  • Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients

    NCT03311321 · start 2017-09-13

    Registered record
    Registry ID
    NCT03311321
    Conditions
    Cardiovascular Diseases; Chronic Kidney Disease Stage 3; Chronic Kidney Disease Stage 4; Chronic Kidney Disease Stage 5; Vitamin K Deficiency; Hemodialysis
    Interventions
    Vitamin K2 (menaquinone-7; 360-mcg/d); Placebo-Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-09-13
    Completion
    2021-12-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Diseases; Chronic Kidney Disease Stage 3; Chronic Kidney Disease Stage 4; Chronic Kidney Disease Stage 5 +2 more
    InterventionVitamin K2 (menaquinone-7; 360-mcg/d); Placebo-Control
    PhaseNot applicable
    Registry statusUnknown

  • VItamin K Inhibition and NeurocoGnition (VIKING)

    NCT03276377 · start 2017-09

    Registered record
    Registry ID
    NCT03276377
    Conditions
    Neurocognitive Disorders
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-09
    Completion
    2018-09
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeurocognitive Disorders
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Balancing of Patients Treated by Vitamin K Antagonists (VKAS) in General Medicine

    NCT03914053 · start 2017-07-01

    Registered record
    Registry ID
    NCT03914053
    Conditions
    Thromboembolism
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-07-01
    Completion
    2018-12-31
    Enrolment
    3,387

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThromboembolism
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Assessment of a Diagnostic Medical Device for the INR (International Normalized Ratio) Measurement

    NCT02779400 · start 2016-05-23

    Registered record
    Registry ID
    NCT02779400
    Conditions
    Healthy; Heart Valves; Arrhythmias, Cardiac; Thromboembolism
    Interventions
    Self testing INR device
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-05-23
    Completion
    2018-06-01
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Heart Valves; Arrhythmias, Cardiac; Thromboembolism
    InterventionSelf testing INR device
    PhaseNot applicable
    Registry statusCompleted

  • Evaluation of Diagnostic Efficiency of PIVKA-II and Other Tumor Markers in HCC

    NCT03047603 · start 2016-05-01

    Registered record
    Registry ID
    NCT03047603
    Conditions
    Hepatocellular Carcinoma
    Interventions
    PIVKA-II
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-05-01
    Completion
    2019-03-20
    Enrolment
    4,005

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatocellular Carcinoma
    InterventionPIVKA-II
    PhaseNot recorded
    Registry statusCompleted

  • International Normalised Ratio Evaluation by Generalist Practitioners in Full-time Care Establishments for the Elderly

    NCT02614573 · start 2016-02

    Registered record
    Registry ID
    NCT02614573
    Conditions
    Aged; Nursing Homes
    Interventions
    CoagucheckXSR Capillary INR measures
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-02
    Completion
    2016-08-13
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAged; Nursing Homes
    InterventionCoagucheckXSR Capillary INR measures
    PhaseNot applicable
    Registry statusCompleted

  • Non-vitamin K Antagonist Oral Anticoagulants in Patients With Atrial High Rate Episodes

    NCT02618577 · start 2016-02

    Registered record
    Registry ID
    NCT02618577
    Conditions
    Atrial High Rate Episodes
    Interventions
    Edoxaban; ASA
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2016-02
    Completion
    2022-12-31
    Enrolment
    2,608

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial High Rate Episodes
    InterventionEdoxaban; ASA
    PhasePhase 3
    Registry statusTerminated

  • Vitamin K2 Effect on Vascular Stiffening in Subjects With a Poor Vitamin K-status

    NCT02404519 · start 2016-01

    Registered record
    Registry ID
    NCT02404519
    Conditions
    Vascular Stiffness
    Interventions
    Menaquinone-7; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-01
    Completion
    2018-09
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVascular Stiffness
    InterventionMenaquinone-7; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Patient Convenience Study (RE-SONANCE)

    NCT02684981 · start 2015-11-11

    Registered record
    Registry ID
    NCT02684981
    Conditions
    Atrial Fibrillation; Stroke
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-11-11
    Completion
    2017-06-01
    Enrolment
    9,472

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Stroke
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • RE-COVERY DVT/PE: Global Study on Treatment Secondary Prevention of Acute Venous Thromboembolism

    NCT02596230 · start 2015-11-05

    Registered record
    Registry ID
    NCT02596230
    Conditions
    Venous Thromboembolism
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-11-05
    Completion
    2019-03-31
    Enrolment
    7,797

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVenous Thromboembolism
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Comparison of Two Nutrition Interventions in Young Children in El Salvador

    NCT02567981 · start 2015-09

    Registered record
    Registry ID
    NCT02567981
    Conditions
    Micronutrient Deficiency
    Interventions
    21 micronutrient-fortified supplement; Cereal Fortificado (Fortified Cereal); Ferrous sulphate; Vitamin A
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-09
    Completion
    2020-09
    Enrolment
    4,577

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMicronutrient Deficiency
    Intervention21 micronutrient-fortified supplement; Cereal Fortificado (Fortified Cereal); Ferrous sulphate; Vitamin A
    PhaseNot applicable
    Registry statusUnknown

  • ORal anticoaGulants in diAbetic and Nondiabetic Patients With nOn-valvular Atrial fibrillatioN (ORGANON)

    NCT02935855 · start 2015-09

    Registered record
    Registry ID
    NCT02935855
    Conditions
    Diabetes
    Interventions
    Dabigatran; Apixaban; Rivaroxaban; Edoxaban; Warfarin; Acenocumarole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-09
    Completion
    2019-09
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes
    InterventionDabigatran; Apixaban; Rivaroxaban; Edoxaban +2 more
    PhasePhase 4
    Registry statusCompleted