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AMR Drug RepurposingSmart Screeningresearch prototype

Nalbuphine Hydrochloride

FDA-approved product (solution, intramuscular, intravenous, subcutaneous), marketed as Nalbuphine, Nalbuphine Hydrochloride, Nubain.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Nalbuphine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Morphinan derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli38.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae34.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nalbuphine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nalbuphine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Unilateral Spinal vs General Anaesthesia in Low EF Patients: A Hemodynamic Comparison

    NCT07752303 · start 2026-07-05

    Registered record
    Registry ID
    NCT07752303
    Conditions
    Hemodynamic (MAP) Stability
    Interventions
    Unilateral spinal anesthesia; General anesthesia
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Enrolling by invitation
    Start
    2026-07-05
    Completion
    2026-12
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodynamic (MAP) Stability
    InterventionUnilateral spinal anesthesia; General anesthesia
    PhaseNot recorded
    Registry statusEnrolling by invitation

  • COMPARISON OF AIRWAY NERVE BLOCK VERSUS NEBULIZED LIDOCAINE ON HEMODYNAMIC RESPONSES DURING AWAKE FIBEROPTIC INTUBATION

    NCT07627100 · start 2026-06-28

    Registered record
    Registry ID
    NCT07627100
    Conditions
    Blood Pressure After Nerve Block; Hemodynamic Stability During Awake Intubation
    Interventions
    Nebulized Lidocaine; Nerve Block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-06-28
    Completion
    2027-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood Pressure After Nerve Block; Hemodynamic Stability During Awake Intubation
    InterventionNebulized Lidocaine; Nerve Block
    PhaseNot applicable
    Registry statusNot yet recruiting

  • FASCIA ILIACA BLOCK VERSUS INTRAVENOUS NALBUPHINE AS ANALGESIC METHOD BEFORE POSITIONING FOR SPINAL ANESTHESIA IN PATIENTS UNDERGOING SURGERY FOR HIP FRACTURES

    NCT07613801 · start 2026-05-12

    Registered record
    Registry ID
    NCT07613801
    Conditions
    Hip Fracture Surgeries
    Interventions
    Bupivacain; Nalbuphine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2026-05-12
    Completion
    2026-11-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Fracture Surgeries
    InterventionBupivacain; Nalbuphine
    PhasePhase 4
    Registry statusActive not recruiting

  • Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery

    NCT07197684 · start 2026-03-16

    Registered record
    Registry ID
    NCT07197684
    Conditions
    Breast Cancer; Pain, Chronic; Post Surgical Pain
    Interventions
    Ketamine; Pecs block; Nalbuphine; Paracetamol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-03-16
    Completion
    2027-05-01
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer; Pain, Chronic; Post Surgical Pain
    InterventionKetamine; Pecs block; Nalbuphine; Paracetamol
    PhaseNot applicable
    Registry statusNot yet recruiting

  • A Food Effect Study to Evaluate the Relative Bioavailability of Nalbuphine Extended-Release Tablets (NAL ER) in Healthy Participants

    NCT07487740 · start 2026-02-27

    Registered record
    Registry ID
    NCT07487740
    Conditions
    Healthy Participants
    Interventions
    NAL ER
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2026-02-27
    Completion
    2026-05-19
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Participants
    InterventionNAL ER
    PhasePhase 1
    Registry statusCompleted

  • Comparison Between External Oblique Intercostal Plane Block and Rectus Sheath Block Combined With Transversus Abdominis Plane Block

    NCT07384000 · start 2026-01-20

    Registered record
    Registry ID
    NCT07384000
    Conditions
    Pain Management; Anesthesia , Analgesia; Nerve Block
    Interventions
    External intercostal plane puncture; control group (nalbuphine); the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-01-20
    Completion
    2026-04-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain Management; Anesthesia , Analgesia; Nerve Block
    InterventionExternal intercostal plane puncture; control group (nalbuphine); the single-puncture technique of (rectus sheath block) combined with (Transversus abdominis plane block)
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Femoral Rami Obturator Nerve Trunk (FRONT) Block in Intramedullary Nail Surgery .

    NCT07268911 · start 2026-01-01

    Registered record
    Registry ID
    NCT07268911
    Conditions
    Anterior Hip Analgesia
    Interventions
    Femoral rami obturator nerve trunk (FRONT) block; Sham block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2026-01-01
    Completion
    2026-06-01
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnterior Hip Analgesia
    InterventionFemoral rami obturator nerve trunk (FRONT) block; Sham block
    PhaseNot applicable
    Registry statusCompleted

  • Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery

    NCT07279727 · start 2026-01-01

    Registered record
    Registry ID
    NCT07279727
    Conditions
    Regional Anaesthesia
    Interventions
    Nalbuphine; Dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Not yet recruiting
    Start
    2026-01-01
    Completion
    2027-04-01
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRegional Anaesthesia
    InterventionNalbuphine; Dexmedetomidine
    PhasePhase 1
    Registry statusNot yet recruiting

  • Impact of Frailty on Nalbuphine Dose for Postoperative Analgesia in Elderly Patients Undergoing Laparoscopic GI Surgery

    NCT06953570 · start 2025-10-01

    Registered record
    Registry ID
    NCT06953570
    Conditions
    PCIA; Frailty; Laparoscopic Gastrointestinal Surgery
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-10-01
    Completion
    2026-10-10
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPCIA; Frailty; Laparoscopic Gastrointestinal Surgery
    InterventionNot recorded
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery

    NCT07340008 · start 2025-09-01

    Registered record
    Registry ID
    NCT07340008
    Conditions
    Orofacial Clefts; Cleft Lip and Palate; Alveolar Ridge Defect
    Interventions
    ketamine; Nalbuphine; Dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-09-01
    Completion
    2029-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOrofacial Clefts; Cleft Lip and Palate; Alveolar Ridge Defect
    Interventionketamine; Nalbuphine; Dexmedetomidine
    PhaseNot applicable
    Registry statusRecruiting

  • Ultrasound-Guided Erector Spinae Plane Block Versus Intravenous Nalbuphine

    NCT07391475 · start 2025-07-08

    Registered record
    Registry ID
    NCT07391475
    Conditions
    Postoperative Pain Management
    Interventions
    Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2025-07-08
    Completion
    2026-01-07
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain Management
    InterventionErector Spinae (ESP) Block with Bupivacaine (Marcaine®)
    PhasePhase 4
    Registry statusCompleted

  • Analgesic Efficacy of Fascia Iliaca Compartment Block Compared With Intrathecal Nalbuphine for Hip Surgery Under Spinal Anesthesia

    NCT06818396 · start 2025-02-18

    Registered record
    Registry ID
    NCT06818396
    Conditions
    Postoperative Pain
    Interventions
    US-guided fascia iliaca compartment block (FICB) and spinal anesthesia; Intrathecal nalbuphine and spinal anesthesia; Spinal anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-02-18
    Completion
    2026-10-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionUS-guided fascia iliaca compartment block (FICB) and spinal anesthesia; Intrathecal nalbuphine and spinal anesthesia; Spinal anesthesia
    PhaseNot applicable
    Registry statusRecruiting

  • Nalbuphine Versus Tramadol on Post Operative Analgesia in Abdominal Surgery on Pediatric Cancer Patient

    NCT07110051 · start 2025-01-15

    Registered record
    Registry ID
    NCT07110051
    Conditions
    Tramadol; Nalbuphine; Abdominal Surgeries; Pediatric Cancer
    Interventions
    Nalbuphine; Tramadol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-01-15
    Completion
    2025-10-15
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTramadol; Nalbuphine; Abdominal Surgeries; Pediatric Cancer
    InterventionNalbuphine; Tramadol
    PhaseNot applicable
    Registry statusRecruiting

  • The Analgesic Efficacy of Perineural Nalbuphine as an Adjuvant to Bupivacaine in Ultrasound Guided Superficial Cervical Plexus Nerve Block for Thyroid Surgeries. A Double Blinded Randomized Controlled Trial.

    NCT06633068 · start 2024-07-15

    Registered record
    Registry ID
    NCT06633068
    Conditions
    Intra and Postoperative Pain Management
    Interventions
    Adding perineural Nalbuphine to Bupivacaine in superficial cervical nerve block
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2024-07-15
    Completion
    2025-07
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntra and Postoperative Pain Management
    InterventionAdding perineural Nalbuphine to Bupivacaine in superficial cervical nerve block
    PhasePhase 2
    Registry statusRecruiting

  • Opioid-based Versus Opioid-free Anaesthesia for Laparoscopic Cholecystectomy

    NCT06476600 · start 2024-07-01

    Registered record
    Registry ID
    NCT06476600
    Conditions
    Surgical Procedure, Unspecified; Laparoscopic Cholecystectomy
    Interventions
    Dexmedetomidine injection; Nalbuphine Injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-07-01
    Completion
    2024-10-31
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Procedure, Unspecified; Laparoscopic Cholecystectomy
    InterventionDexmedetomidine injection; Nalbuphine Injection
    PhaseNot applicable
    Registry statusCompleted