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AMR Drug RepurposingSmart Screeningresearch prototype

Desmopressin Acetate

FDA-approved product (solution, nasal), marketed as Concentraid, Ddavp, Ddavp (Needs No Refrigeration) and 9 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Desmopressin Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Central diabetes insipidus
  • Diabetes insipidus
  • Enuresis
  • Head injury
  • Hemorrhage
  • Nasal congestion
  • Nocturia
  • Von Willebrand disease (hereditary or acquired)

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vasopressin and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA65.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae45.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Desmopressin Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Desmopressin Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Trial to Investigate Efficacy, Safety and Tolerability of FE 201836 for Nocturia Due to Nocturnal Polyuria in Adults

    NCT03201419 · start 2017-07-27

    Registered record
    Registry ID
    NCT03201419
    Conditions
    Nocturia
    Interventions
    FE 201836; Desmopressin; Placebo oral solution; Placebo ODT
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-07-27
    Completion
    2019-10-31
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionFE 201836; Desmopressin; Placebo oral solution; Placebo ODT
    PhasePhase 2
    Registry statusCompleted

  • Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Male Subjects

    NCT02904759 · start 2016-09

    Registered record
    Registry ID
    NCT02904759
    Conditions
    Nocturia
    Interventions
    Desmopressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-09
    Completion
    2017-09-29
    Enrolment
    342

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Study of Minirin Melt® in Adult Patients With Nocturia

    NCT03089073 · start 2015-07-13

    Registered record
    Registry ID
    NCT03089073
    Conditions
    Nocturia
    Interventions
    Desmopressin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2015-07-13
    Completion
    2018-10-05
    Enrolment
    835

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin
    PhaseNot recorded
    Registry statusTerminated

  • Comparison Between Desmopressin and Fesoterodine for Treatment of Night Time Voiding in Women Aged 65 and Older

    NCT02262936 · start 2015-07

    Registered record
    Registry ID
    NCT02262936
    Conditions
    Nocturia
    Interventions
    Desmopressin; Fesoterodine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2015-07
    Completion
    2016-02
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin; Fesoterodine
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Characterization of Laboratory Response to DDAVP in Adult Hemophilia A Carriers

    NCT02506023 · start 2015-07

    Registered record
    Registry ID
    NCT02506023
    Conditions
    Hemophilia A
    Interventions
    Desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-07
    Completion
    2018-06-15
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemophilia A
    InterventionDesmopressin
    PhasePhase 1
    Registry statusCompleted

  • Intranasal Desmopressin vs IV Ketorolac in Renal Colic Pain Control

    NCT02937896 · start 2015-01

    Registered record
    Registry ID
    NCT02937896
    Conditions
    Renal Colic
    Interventions
    Desmopressin; Ketorolac; Normal Saline; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01
    Completion
    2016-04
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Colic
    InterventionDesmopressin; Ketorolac; Normal Saline; Normal Saline
    PhaseNot applicable
    Registry statusCompleted

  • Minirin Versus Oxybutynin for Nocturnal Enuresis in Children

    NCT02538302 · start 2013-07

    Registered record
    Registry ID
    NCT02538302
    Conditions
    Nocturnal Enuresis
    Interventions
    Minirin; Oxybutynin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-07
    Completion
    2015-08
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturnal Enuresis
    InterventionMinirin; Oxybutynin
    PhasePhase 3
    Registry statusCompleted

  • Desmopressin (DDAVP) in Patients With Colorectal Cancer and Rectal Bleeding

    NCT01623206 · start 2013-04

    Registered record
    Registry ID
    NCT01623206
    Conditions
    Colorectal Cancer; Rectal Bleeding
    Interventions
    Desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-04
    Completion
    2017-08
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer; Rectal Bleeding
    InterventionDesmopressin
    PhasePhase 2
    Registry statusCompleted

  • Daytime Impact Sleep Study

    NCT01779466 · start 2013-04

    Registered record
    Registry ID
    NCT01779466
    Conditions
    Nocturia
    Interventions
    Desmopressin; Placebo (not active)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-04
    Completion
    2014-06
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin; Placebo (not active)
    PhasePhase 2
    Registry statusTerminated

  • Comparative Trial to Investigate the Efficacy and Safety of Desmopressin for the Treatment of Nocturia in Adult Women

    NCT01684800 · start 2012-09

    Registered record
    Registry ID
    NCT01684800
    Conditions
    Nocturia
    Interventions
    A. Desmopressin 10 microgram; B: Desmopressin 25 microgram; C: Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-09
    Completion
    2013-06
    Enrolment
    178

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionA. Desmopressin 10 microgram; B: Desmopressin 25 microgram; C: Placebo
    PhasePhase 2
    Registry statusCompleted

  • Comparative Trial to Investigate the Efficacy and Safety of Desmopressin for the Treatment of Nocturia in Adult Men

    NCT01694498 · start 2012-09

    Registered record
    Registry ID
    NCT01694498
    Conditions
    Nocturia
    Interventions
    A: Desmopressin 25 µg; B. Desmopressin 50 µg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-09
    Completion
    2013-06
    Enrolment
    183

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionA: Desmopressin 25 µg; B. Desmopressin 50 µg; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Drug

    NCT01841515 · start 2012-08

    Registered record
    Registry ID
    NCT01841515
    Conditions
    Bleeding; Tachycardia; Dyspnea
    Interventions
    Desmopressin administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-08
    Completion
    2013-04
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBleeding; Tachycardia; Dyspnea
    InterventionDesmopressin administration
    PhasePhase 1
    Registry statusCompleted

  • The Effect of Gender on Antidiuresis - Evaluated by Graded Low Dose Desmopressin Infusion

    NCT02068560 · start 2012-05

    Registered record
    Registry ID
    NCT02068560
    Conditions
    Gender Difference in V2 Receptor Function in Response to dDAVP Infusion; Nocturia; Nocturnal Enuresis
    Interventions
    dDAVP infusion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-05
    Completion
    2014-12
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGender Difference in V2 Receptor Function in Response to dDAVP Infusion; Nocturia; Nocturnal Enuresis
    InterventiondDAVP infusion
    PhaseNot applicable
    Registry statusCompleted

  • Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction

    NCT01582542 · start 2012-04

    Registered record
    Registry ID
    NCT01582542
    Conditions
    Nocturnal Enuresis
    Interventions
    Desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-04
    Completion
    2014-03
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturnal Enuresis
    InterventionDesmopressin
    PhasePhase 4
    Registry statusUnknown

  • Desmopressin Melt Therapy in Nocturnal Polyuria Patients: Pharmacodynamic Study

    NCT01439997 · start 2012-03-26

    Registered record
    Registry ID
    NCT01439997
    Conditions
    Nocturia
    Interventions
    Desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-03-26
    Completion
    2015-02-01
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin
    PhasePhase 4
    Registry statusCompleted