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AMR Drug RepurposingSmart Screeningresearch prototype

Desmopressin Acetate

FDA-approved product (solution, nasal), marketed as Concentraid, Ddavp, Ddavp (Needs No Refrigeration) and 9 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Desmopressin Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Central diabetes insipidus
  • Diabetes insipidus
  • Enuresis
  • Head injury
  • Hemorrhage
  • Nasal congestion
  • Nocturia
  • Von Willebrand disease (hereditary or acquired)

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vasopressin and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA, E. coli and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA65.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae45.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Desmopressin Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Desmopressin Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Transfusion Reduction in High-Bleeding-Risk Cardiac Surgery With Desmopressin

    NCT07012837 · start 2025-07

    Registered record
    Registry ID
    NCT07012837
    Conditions
    Adult Patients Undergoing Cardiac Surgery; High Bleeding Risks; Planned Elective Cardiac Surgery Using CPB
    Interventions
    Placebo; Desmopresin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2025-07
    Completion
    2027-08
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Patients Undergoing Cardiac Surgery; High Bleeding Risks; Planned Elective Cardiac Surgery Using CPB
    InterventionPlacebo; Desmopresin
    PhasePhase 3
    Registry statusNot yet recruiting

  • Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial

    NCT06337838 · start 2025-06-09

    Registered record
    Registry ID
    NCT06337838
    Conditions
    Chronic Kidney Diseases; Acute Kidney Injury; Bleeding; Surgery
    Interventions
    Desmopressin Injectable Solution; Tranexamic Acid Injectable Product; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2025-06-09
    Completion
    2027-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Diseases; Acute Kidney Injury; Bleeding; Surgery
    InterventionDesmopressin Injectable Solution; Tranexamic Acid Injectable Product; Placebo
    PhasePhase 3
    Registry statusRecruiting

  • Effectiveness of Pelvic Floor Muscle Rehabilitation Combined With Desmopressin in Children With Primary Monosymptomatic Nocturnal Enuresis

    NCT06883851 · start 2025-03-11

    Registered record
    Registry ID
    NCT06883851
    Conditions
    Primary Nocturnal Enuresis; Nocturnal Enuresis in Children
    Interventions
    Structured pelvic floor rehabilitation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-03-11
    Completion
    2027-08-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Nocturnal Enuresis; Nocturnal Enuresis in Children
    InterventionStructured pelvic floor rehabilitation
    PhaseNot applicable
    Registry statusRecruiting

  • Ginko Biloba Versus Desmopressin in Treatment of Children With Monosymptomatic Nocturnal Enuresis

    NCT06772584 · start 2024-01-01

    Registered record
    Registry ID
    NCT06772584
    Conditions
    Enuresis, Nocturnal
    Interventions
    Desmopressin Acetate 0.2 mg Tablets; Ginkgobiloba
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-01-01
    Completion
    2024-12-01
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnuresis, Nocturnal
    InterventionDesmopressin Acetate 0.2 mg Tablets; Ginkgobiloba
    PhaseNot applicable
    Registry statusCompleted

  • International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia

    NCT07576036 · start 2023-11-01

    Registered record
    Registry ID
    NCT07576036
    Conditions
    Hyponatremia Symptomatic; Osmotic Demyelination Syndrome; Cerebral Edema
    Interventions
    Hypertonic 3% saline
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Enrolling by invitation
    Start
    2023-11-01
    Completion
    2026-09-30
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyponatremia Symptomatic; Osmotic Demyelination Syndrome; Cerebral Edema
    InterventionHypertonic 3% saline
    PhaseNot recorded
    Registry statusEnrolling by invitation

  • Adding Desmopressin to Tamsulosin for Treatment of BPH

    NCT05945420 · start 2023-07-20

    Registered record
    Registry ID
    NCT05945420
    Conditions
    Nocturnal Polyurea in Patients With BPH
    Interventions
    Desmopressin Acetate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2023-07-20
    Completion
    2024-02-10
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturnal Polyurea in Patients With BPH
    InterventionDesmopressin Acetate; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Safety Outcomes Post Kidney Biopsy - Randomized Clinical Evaluation of Efficacy of Desmopressin

    NCT05467033 · start 2022-09-01

    Registered record
    Registry ID
    NCT05467033
    Conditions
    Kidney Biopsy
    Interventions
    Desmopressin; intravenous infusion NaCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2022-09-01
    Completion
    2026-08-31
    Enrolment
    424

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Biopsy
    InterventionDesmopressin; intravenous infusion NaCl
    PhasePhase 3
    Registry statusRecruiting

  • Intravenous Tranexamic Acid and Intramyometrial Desmopressin Effect on Blood Loss During Laparoscopic Myomectomy.

    NCT05517590 · start 2022-09-01

    Registered record
    Registry ID
    NCT05517590
    Conditions
    Leiomyoma, Uterine; Intraoperative Blood Loss
    Interventions
    Tranexamic acid; Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-09-01
    Completion
    2024-04-30
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeiomyoma, Uterine; Intraoperative Blood Loss
    InterventionTranexamic acid; Saline
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Laser Acupuncture for Treating Monosymptomatic Nocturnal Enuresis in Adolescent Females

    NCT05399173 · start 2022-06-02

    Registered record
    Registry ID
    NCT05399173
    Conditions
    Non-Specific Urethritis
    Interventions
    infrared (gallium aluminum arsenide laser); medical treatment(desmopressin acetate)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-06-02
    Completion
    2023-09-08
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-Specific Urethritis
    Interventioninfrared (gallium aluminum arsenide laser); medical treatment(desmopressin acetate)
    PhaseNot applicable
    Registry statusUnknown

  • the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock

    NCT04586790 · start 2020-10-15

    Registered record
    Registry ID
    NCT04586790
    Conditions
    Spinal Shock
    Interventions
    Midodrine Oral Tablet; Minirin oral tablet; Nor-Adrenaline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2020-10-15
    Completion
    2021-01-28
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Shock
    InterventionMidodrine Oral Tablet; Minirin oral tablet; Nor-Adrenaline
    PhasePhase 2
    Registry statusUnknown

  • Specified Drug Use-results Survey (Long-term Use) on MINIRINMELT® OD Tablet (Nocturia)

    NCT04329975 · start 2020-05-19

    Registered record
    Registry ID
    NCT04329975
    Conditions
    Nocturia Due to Nocturnal Polyuria
    Interventions
    Desmopressin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-05-19
    Completion
    2024-09-25
    Enrolment
    1,087

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia Due to Nocturnal Polyuria
    InterventionDesmopressin
    PhaseNot recorded
    Registry statusCompleted

  • Posterior Tibial Nerve Stimulation Vs Desmopressin In Children With Primary Monosymptomatic Nocturnal Enuresis

    NCT04545931 · start 2020-03-15

    Registered record
    Registry ID
    NCT04545931
    Conditions
    Primary Monosymptomatic Nocturnal Enuresis
    Interventions
    Posterior tibial nerve stimulation; Desmopressin Acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2020-03-15
    Completion
    2020-12-15
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Monosymptomatic Nocturnal Enuresis
    InterventionPosterior tibial nerve stimulation; Desmopressin Acetate
    PhasePhase 4
    Registry statusUnknown

  • Study on Chinese and Western Medicine in MNE Children

    NCT03733873 · start 2018-09-01

    Registered record
    Registry ID
    NCT03733873
    Conditions
    Monosymptomatic Nocturnal Enuresis
    Interventions
    Desmopressin; Suoquan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-09-01
    Completion
    2020-07-30
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMonosymptomatic Nocturnal Enuresis
    InterventionDesmopressin; Suoquan
    PhaseNot applicable
    Registry statusCompleted

  • To Evaluate the Renal Tubular Function Pre and Post Nephrectomy in Living Donors

    NCT03676361 · start 2018-08-29

    Registered record
    Registry ID
    NCT03676361
    Conditions
    Kidney Damage
    Interventions
    Desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2018-08-29
    Completion
    2019-04-26
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Damage
    InterventionDesmopressin
    PhasePhase 4
    Registry statusWithdrawn

  • The Effect of Selecting Treatment With Desmopressin or Alarm to Children With Enuresis Based on Home Recordings.

    NCT03389412 · start 2017-10-01

    Registered record
    Registry ID
    NCT03389412
    Conditions
    Enuresis, Nocturnal
    Interventions
    Desmopressin; Conditional alarm
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-10-01
    Completion
    2023-01-03
    Enrolment
    324

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnuresis, Nocturnal
    InterventionDesmopressin; Conditional alarm
    PhasePhase 4
    Registry statusCompleted