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AMR Drug RepurposingSmart Screeningresearch prototype

Beta Carotene

FDA-approved product (capsule, oral), marketed as Solatene.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Beta Carotene
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Beta Carotene. Its therapeutic class is shown instead.

WHO therapeutic group
Vitamin a, plain; Protectives against uv-radiation for systemic use
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Beta Carotene, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli22.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae10.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis35.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Beta Carotene in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Beta Carotene with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

    NCT03126916 · start 2018-05-14

    Registered record
    Registry ID
    NCT03126916
    Conditions
    Ganglioneuroblastoma; Ganglioneuroblastoma, Nodular; Neuroblastoma
    Interventions
    Autologous Hematopoietic Stem Cell Transplantation; Biospecimen Collection; Bone Marrow Aspiration and Biopsy; Busulfan; Carboplatin; Cisplatin; Computed Tomography; Cyclophosphamide; Dexrazoxane Hydrochloride; Dinutuximab; Doxorubicin Hydrochloride; Echocardiography Test; Etoposide Phosphate; External Beam Radiation Therapy; Iobenguane I-123; Iobenguane I-131; Isotretinoin; Lorlatinib; Magnetic Resonance Imaging; Melphalan Hydrochloride; Multigated Acquisition Scan; Positron Emission Tomography; Sargramostim; Therapeutic Conventional Surgery; Thiotepa; Topotecan Hydrochloride; Vincristine Sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2018-05-14
    Completion
    2030-09-30
    Enrolment
    750

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGanglioneuroblastoma; Ganglioneuroblastoma, Nodular; Neuroblastoma
    InterventionAutologous Hematopoietic Stem Cell Transplantation; Biospecimen Collection; Bone Marrow Aspiration and Biopsy; Busulfan +23 more
    PhasePhase 3
    Registry statusRecruiting

  • Effect of Iron and Zinc Supplementation on B-carotene Bioavailability in Healthy Males

    NCT05840848 · start 2017-11-21

    Registered record
    Registry ID
    NCT05840848
    Conditions
    Bioavailability
    Interventions
    Control beta-carotene supplement plus Placebo; Control beta-carotene supplement plus iron Supplement; Control beta-carotene supplement plus zinc Supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-11-21
    Completion
    2018-06-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBioavailability
    InterventionControl beta-carotene supplement plus Placebo; Control beta-carotene supplement plus iron Supplement; Control beta-carotene supplement plus zinc Supplement
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β

    NCT03005496 · start 2017-01

    Registered record
    Registry ID
    NCT03005496
    Conditions
    PreTerm Birth
    Interventions
    Zinc; Nifedipine; Beta Carotene; Vitamin D3; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-01
    Completion
    2017-06
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreTerm Birth
    InterventionZinc; Nifedipine; Beta Carotene; Vitamin D3 +1 more
    PhasePhase 4
    Registry statusCompleted

  • Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR

    NCT03659058 · start 2016-03-02

    Registered record
    Registry ID
    NCT03659058
    Conditions
    Fibrosis, Liver
    Interventions
    silymarin; Ursodeoxycholic Acid; Antioxidants; Colchicine; FOLLOW UP
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-03-02
    Completion
    2018-08-01
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFibrosis, Liver
    Interventionsilymarin; Ursodeoxycholic Acid; Antioxidants; Colchicine +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Novel Metabolites of Beta-Carotene and Lycopene

    NCT02550483 · start 2015-09

    Registered record
    Registry ID
    NCT02550483
    Conditions
    Healthy
    Interventions
    Base diet + high beta-carotene tomato juice; Base diet + high lycopene tomato juice; Base diet + placebo beverage
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-09
    Completion
    2015-11
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionBase diet + high beta-carotene tomato juice; Base diet + high lycopene tomato juice; Base diet + placebo beverage
    PhaseNot applicable
    Registry statusCompleted

  • Lycopene and Beta-carotene Metabolism in the Digestive Tract of Healthy Men

    NCT03492593 · start 2014-09

    Registered record
    Registry ID
    NCT03492593
    Conditions
    Digestion Chambers; Stability and Metabolism of Carotenoids and Vitamin E
    Interventions
    lycopene; beta-carotene; control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-09
    Completion
    2016-03
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDigestion Chambers; Stability and Metabolism of Carotenoids and Vitamin E
    Interventionlycopene; beta-carotene; control
    PhaseNot applicable
    Registry statusCompleted

  • Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari

    NCT02210507 · start 2014-07

    Registered record
    Registry ID
    NCT02210507
    Conditions
    Vitamin A Deficiency
    Interventions
    Biofortified cassava gari; White cassava gari; White cassava gari + red palm oil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-07
    Completion
    2014-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin A Deficiency
    InterventionBiofortified cassava gari; White cassava gari; White cassava gari + red palm oil
    PhaseNot applicable
    Registry statusCompleted

  • Bioavailability of Carotenoids Added Into Processed Foods

    NCT02246985 · start 2014-07

    Registered record
    Registry ID
    NCT02246985
    Conditions
    Cardiovascular Disease
    Interventions
    Control; Vegetable bread only; Plain bread with vegetable mayonnaise; Vegetable bread with plain mayonnaise
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-07
    Completion
    2016-07
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Disease
    InterventionControl; Vegetable bread only; Plain bread with vegetable mayonnaise; Vegetable bread with plain mayonnaise
    PhaseNot applicable
    Registry statusCompleted

  • QOL, ADL and Pain Before and After Intervention With N3 From Krill With D3.

    NCT02008760 · start 2013-02

    Registered record
    Registry ID
    NCT02008760
    Conditions
    Quality of Life; Pain
    Interventions
    Omega Krill with D3
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2013-02
    Completion
    2014-06
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionQuality of Life; Pain
    InterventionOmega Krill with D3
    PhasePhase 1
    Registry statusUnknown

  • Effect of Small Daily Doses of B-carotene on Breast Milk Retinol

    NCT01803659 · start 2013-01

    Registered record
    Registry ID
    NCT01803659
    Conditions
    Vitamin A Status
    Interventions
    b-carotene; retinyl palmitate; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-01
    Completion
    2013-06
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin A Status
    Interventionb-carotene; retinyl palmitate; placebo
    PhaseNot applicable
    Registry statusCompleted

  • A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus

    NCT02263352 · start 2013-01

    Registered record
    Registry ID
    NCT02263352
    Conditions
    Positive Regulation of Oxidative Stress Process
    Interventions
    Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day; Scaling and root planing
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-01
    Completion
    2013-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPositive Regulation of Oxidative Stress Process
    InterventionLycored soft gels Jagsonpal Pharma, Systemic 8mgms/day; Scaling and root planing
    PhasePhase 4
    Registry statusCompleted

  • Antioxidants for Prevention of Cataracts Follow-up Study

    NCT01664819 · start 2012-08

    Registered record
    Registry ID
    NCT01664819
    Conditions
    Cataract
    Interventions
    Antioxidant; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-08
    Completion
    2013-08
    Enrolment
    576

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCataract
    InterventionAntioxidant; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children

    NCT01695148 · start 2012-08

    Registered record
    Registry ID
    NCT01695148
    Conditions
    Vitamin A Deficiency; Low Serum Retinol
    Interventions
    β-Carotene Biofortified Maize Flour; White Maize Flour
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-08
    Completion
    2013-06
    Enrolment
    1,228

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin A Deficiency; Low Serum Retinol
    Interventionβ-Carotene Biofortified Maize Flour; White Maize Flour
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Yellow Cassava to Improve Vitamin A Status of Kenyan School Children

    NCT01614483 · start 2012-05

    Registered record
    Registry ID
    NCT01614483
    Conditions
    Vitamin A Deficiency
    Interventions
    Yellow cassava; White cassava; White cassava
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-05
    Completion
    2012-11
    Enrolment
    341

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin A Deficiency
    InterventionYellow cassava; White cassava; White cassava
    PhaseNot applicable
    Registry statusCompleted

  • Provitamin A Absorption and Conversion With Avocados

    NCT01432210 · start 2011-09

    Registered record
    Registry ID
    NCT01432210
    Conditions
    Healthy
    Interventions
    Post-prandial Feeding Study
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-09
    Completion
    2012-03
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPost-prandial Feeding Study
    PhaseNot applicable
    Registry statusCompleted