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AMR Drug RepurposingSmart Screeningresearch prototype

Nafarelin Acetate

FDA-approved product (spray, metered, nasal), marketed as Synarel.

Registered studies
12
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Nafarelin Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Endometriosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Gonadotropin-releasing hormones
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA63.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli58.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae38.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis60.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

12registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nafarelin Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nafarelin Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intranasal Nafarelin For Triggering Oocyte Maturation

    NCT06763926 · start 2026-10-15

    Registered record
    Registry ID
    NCT06763926
    Conditions
    Fertility Preservation
    Interventions
    Subcutaneous Triptorelin; Intranasal nafarelin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-10-15
    Completion
    2028-01-15
    Enrolment
    154

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFertility Preservation
    InterventionSubcutaneous Triptorelin; Intranasal nafarelin
    PhasePhase 4
    Registry statusNot yet recruiting

  • GnRH for Luteal Support - Mechanism of Action

    NCT07620067 · start 2026-05-18

    Registered record
    Registry ID
    NCT07620067
    Conditions
    GnRH Antagonist IVF Protocol; Fresh Embryo Transfer; Administration of Hormonal Luteal Support
    Interventions
    GnRH agonist; Progesterone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2026-05-18
    Completion
    2026-12-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGnRH Antagonist IVF Protocol; Fresh Embryo Transfer; Administration of Hormonal Luteal Support
    InterventionGnRH agonist; Progesterone
    PhaseNot recorded
    Registry statusRecruiting

  • Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus Progesterone

    NCT06870266 · start 2025-03

    Registered record
    Registry ID
    NCT06870266
    Conditions
    Ivf; Frozen Embryo Transfer (FET)
    Interventions
    Nafarelin nasal spray; Utrogestan®
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Not yet recruiting
    Start
    2025-03
    Completion
    2027-06
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIvf; Frozen Embryo Transfer (FET)
    InterventionNafarelin nasal spray; Utrogestan®
    PhaseEarly phase 1
    Registry statusNot yet recruiting

  • Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI Cycles

    NCT06150703 · start 2024-06-27

    Registered record
    Registry ID
    NCT06150703
    Conditions
    In Vitro Fertilization; ICSI Intracytoplasmic Spermatozoid Injection
    Interventions
    Ovulation induction with hCG + Luteal phase support with vaginal progesterone; Ovulation triggering by Triptorelin + Luteal phase support by Nafarelin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2024-06-27
    Completion
    2027-09-27
    Enrolment
    652

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIn Vitro Fertilization; ICSI Intracytoplasmic Spermatozoid Injection
    InterventionOvulation induction with hCG + Luteal phase support with vaginal progesterone; Ovulation triggering by Triptorelin + Luteal phase support by Nafarelin
    PhasePhase 3
    Registry statusRecruiting

  • Comparative Evaluation of Efficacy and Safety of Toremifene, Tamoxifen, and Aromatase Inhibitor Plus Ovarian Function Suppression in Hormone Receptor-Positive Early Breast Cancer Among Non-Low-Risk Premenopausal Women: A Real-World Study

    NCT05801705 · start 2023-06-01

    Registered record
    Registry ID
    NCT05801705
    Conditions
    Hormone-receptor-positive Breast Cancer; Premenopausal Breast Cancer; Breast Cancer Patients at Intermediate to High Risk; Ovarian Function Suppression Combined With Aromatase Inhibitor or Tamoxifen or Torimefen
    Interventions
    Aromatase inhibitor; ovarian function suppression (Oophorectomy, Ovarian irradiation, Gonadotropin-releasing hormone agonist); Tamoxifen; toremifene
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2023-06-01
    Completion
    2023-12-30
    Enrolment
    700

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHormone-receptor-positive Breast Cancer; Premenopausal Breast Cancer; Breast Cancer Patients at Intermediate to High Risk; Ovarian Function Suppression Combined With Aromatase Inhibitor or Tamoxifen or Torimefen
    InterventionAromatase inhibitor; ovarian function suppression (Oophorectomy, Ovarian irradiation, Gonadotropin-releasing hormone agonist); Tamoxifen; toremifene
    PhaseNot recorded
    Registry statusUnknown

  • Injection Free IVF

    NCT04850261 · start 2021-05-01

    Registered record
    Registry ID
    NCT04850261
    Conditions
    Fertility Disorders
    Interventions
    hCG Injection; Nafarelin nasal spray
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2021-05-01
    Completion
    2024-03-31
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFertility Disorders
    InterventionhCG Injection; Nafarelin nasal spray
    PhasePhase 2
    Registry statusWithdrawn

  • GnRH Agonist for Luteal Phase Support.

    NCT05484193 · start 2020-06-08

    Registered record
    Registry ID
    NCT05484193
    Conditions
    Use of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles
    Interventions
    GnRH agonist; Progesterone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-06-08
    Completion
    2023-01-01
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUse of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles
    InterventionGnRH agonist; Progesterone
    PhaseNot applicable
    Registry statusUnknown

  • Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders

    NCT04797338 · start 2017-12-29

    Registered record
    Registry ID
    NCT04797338
    Conditions
    Pregnancy Early; Miscarriage; Ovarian Hyperstimulation Syndrome
    Interventions
    Synarel, 0.2 Mg/Inh Nasal Spray; Estrofem; Utrogestan; Hydroxyprogesterone Caproate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-12-29
    Completion
    2021-09-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Early; Miscarriage; Ovarian Hyperstimulation Syndrome
    InterventionSynarel, 0.2 Mg/Inh Nasal Spray; Estrofem; Utrogestan; Hydroxyprogesterone Caproate
    PhasePhase 4
    Registry statusUnknown

  • Protocol to Minimize Injections and Blood Draws for Women Undergoing in Vitro Fertilization

    NCT02865681 · start 2016-07-01

    Registered record
    Registry ID
    NCT02865681
    Conditions
    Infertility
    Interventions
    Menopur; Synarel; HCG trigger; Clomiphene citrate; Letrozole
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-07-01
    Completion
    2017-06-07
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionMenopur; Synarel; HCG trigger; Clomiphene citrate +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Natural Versus HRT Cycles in Frozen Embryo Replacement Treatment

    NCT00843570 · start 2009-11

    Registered record
    Registry ID
    NCT00843570
    Conditions
    Infertility
    Interventions
    Nafarelin acetate, Oestradiol Valerate, Progesterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-11
    Completion
    2013-05
    Enrolment
    159

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionNafarelin acetate, Oestradiol Valerate, Progesterone
    PhasePhase 4
    Registry statusCompleted

  • Short Versus Long Protocol for IVF and IVF+ICSI

    NCT00756028 · start 2009-01

    Registered record
    Registry ID
    NCT00756028
    Conditions
    Infertility; Ovarian Hyperstimulation Syndrome; Quality of Life; Live Birth
    Interventions
    Patients receiving short protocol IVF/ICSI-treatment.; Long protocol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2015-12
    Enrolment
    1,099

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility; Ovarian Hyperstimulation Syndrome; Quality of Life; Live Birth
    InterventionPatients receiving short protocol IVF/ICSI-treatment.; Long protocol
    PhasePhase 4
    Registry statusCompleted

  • Endometriosis : Traditional Medicine vs Hormone Therapy

    NCT00034047 · start 2002-09

    Registered record
    Registry ID
    NCT00034047
    Conditions
    Endometriosis; Pelvic Pain
    Interventions
    Acupuncture; Chinese Products; Nafarelin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2002-09
    Completion
    2006-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis; Pelvic Pain
    InterventionAcupuncture; Chinese Products; Nafarelin
    PhasePhase 1 / Phase 2
    Registry statusCompleted