Nelfinavir Mesylate
FDA-approved product (powder, oral), marketed as Viracept.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- HIV infection
- HIV-1 infection
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Protease inhibitors
- Anti-infective classification
- Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AE04
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA46.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli42.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae34.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis59.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Nelfinavir Mesylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Trimetrexate GlucuronateExisting use: Other agents against amoebiasis and other protozoal diseases88.6% AI-predicted activityagainst E. coliLab records exist17 registered studies
- Folic AcidExisting use: Acne, Anemia, Anemia (phenotype) and 8 more87.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- MethotrexateExisting use: Acute lymphoblastic leukemia, Adenoma, Arthritis and 21 more86.8% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- PralatrexateExisting use: Cancer, Mature T-cell and NK-cell non-Hodgkin lymphoma, Neoplasm and 2 more82.2% AI-predicted activityagainst E. coli44 registered studies
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives81.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Leucovorin CalciumExisting use: Osteosarcoma67.6% AI-predicted activityagainst E. coli50+ registered studies
- LevoleucovorinExisting use: Anemia, Colorectal adenocarcinoma, Colorectal cancer and 3 more67.6% AI-predicted activityagainst E. coli50+ registered studies
- PyrimethamineExisting use: Malaria, Toxoplasmosis64.6% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Copanlisib DihydrochlorideExisting use: Follicular lymphoma, Neoplasm, Neoplasm of mature B-cells63.5% AI-predicted activityagainst E. coli10 registered studies
- AfamelanotideExisting use: Erythropoietic protoporphyria62.6% AI-predicted activityagainst E. coli23 registered studies
- Rimegepant SulfateExisting use: Migraine disorder61.6% AI-predicted activityagainst E. coli50+ registered studies
- Histrelin AcetateExisting use: Neoplasm, Prostate adenocarcinoma, Prostate cancer61.6% AI-predicted activityagainst E. coli13 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
A Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir
NCT00000892
Registered record
- Registry ID
- NCT00000892
- Conditions
- HIV Infections
- Interventions
- Ritonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Delavirdine mesylate
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 1999-08
- Enrolment
- 300
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionRitonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil +2 morePhaseNot applicableRegistry statusCompletedAddition of Efavirenz or Nelfinavir to a Lamivudine/Zidovudine/Indinavir HIV Treatment Regimen
NCT00000903
Registered record
- Registry ID
- NCT00000903
- Conditions
- HIV Infections
- Interventions
- Indinavir sulfate; Lamivudine/Zidovudine; Nelfinavir mesylate; Efavirenz
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2001-07
- Enrolment
- 444
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionIndinavir sulfate; Lamivudine/Zidovudine; Nelfinavir mesylate; EfavirenzPhasePhase 3Registry statusCompletedA Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks
NCT00000914
Registered record
- Registry ID
- NCT00000914
- Conditions
- HIV Infections
- Interventions
- Indinavir sulfate; Ritonavir; Nelfinavir mesylate; Efavirenz
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2000-06
- Enrolment
- 800
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionIndinavir sulfate; Ritonavir; Nelfinavir mesylate; EfavirenzPhaseNot applicableRegistry statusCompletedA Study to Compare The Ability of Different Anti-HIV Drugs to Decrease Viral Load After Nelfinavir (an Anti-HIV Drug)Treatment Failure
NCT00000918
Registered record
- Registry ID
- NCT00000918
- Conditions
- HIV Infections
- Interventions
- Indinavir sulfate; Lamivudine/Zidovudine; Ritonavir; Amprenavir; Efavirenz; Saquinavir; Lamivudine; Stavudine; Zidovudine; Didanosine
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2002-02
- Enrolment
- 300
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionIndinavir sulfate; Lamivudine/Zidovudine; Ritonavir; Amprenavir +6 morePhasePhase 2Registry statusCompletedA Study to Compare Two Different Anti-HIV Drug Regimens
NCT00000924
Registered record
- Registry ID
- NCT00000924
- Conditions
- HIV Infections
- Interventions
- Ritonavir; Nelfinavir mesylate; Nevirapine; Stavudine; Didanosine
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2001-06
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionRitonavir; Nelfinavir mesylate; Nevirapine; Stavudine +1 morePhasePhase 2Registry statusCompletedA Comparison of Nelfinavir Plus Saquinavir Plus Delavirdine or 3TC/ZDV Versus Nelfinavir Plus 3TC/ZDV in HIV-Infected Patients
NCT00001094
Registered record
- Registry ID
- NCT00001094
- Conditions
- HIV Infections
- Interventions
- Lamivudine/Zidovudine; Nelfinavir mesylate; Saquinavir; Delavirdine mesylate
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Withdrawn
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 0
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionLamivudine/Zidovudine; Nelfinavir mesylate; Saquinavir; Delavirdine mesylatePhasePhase 2Registry statusWithdrawnA Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly
NCT00001122
Registered record
- Registry ID
- NCT00001122
- Conditions
- HIV Infections
- Interventions
- Nelfinavir mesylate; Efavirenz; Stavudine; Didanosine
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 74
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionNelfinavir mesylate; Efavirenz; Stavudine; DidanosinePhasePhase 2Registry statusCompletedPhase I Study of Safety, Tolerability, and Pharmacokinetics of Viracept in HIV-1 Infected Children and Exposed Infants
NCT00002164
Registered record
- Registry ID
- NCT00002164
- Conditions
- HIV Infections
- Interventions
- Nelfinavir mesylate
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionNelfinavir mesylatePhasePhase 1Registry statusCompletedViracept Expanded Access Program
NCT00002165
Registered record
- Registry ID
- NCT00002165
- Conditions
- HIV Infections
- Interventions
- Nelfinavir mesylate
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionNelfinavir mesylatePhaseNot applicableRegistry statusCompletedA Phase II, Stratified, Randomized, Double-Blind, Multi-Center Study of the Safety and Efficacy of Adefovir Dipivoxil (ADF) at Two Dose Levels in Triple Combination Therapies With Protease Inhibitors (PI) and Nucleoside Reverse Transcriptase Inhibitors (RTI) for the Treatment of HIV-Infected Patient
NCT00002184
Registered record
- Registry ID
- NCT00002184
- Conditions
- HIV Infections
- Interventions
- Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Lamivudine; Stavudine; Zidovudine
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionNelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir +3 morePhasePhase 2Registry statusCompletedA Study of Ritonavir (ABT-538) When Used With Nelfinavir in HIV-Infected Patients
NCT00002201
Registered record
- Registry ID
- NCT00002201
- Conditions
- HIV Infections
- Interventions
- Ritonavir; Nelfinavir mesylate
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionRitonavir; Nelfinavir mesylatePhaseNot applicableRegistry statusCompletedSafety and Effectiveness of Giving Combinations of Three or Four Anti-HIV Drugs to HIV-Infected Patients
NCT00002211
Registered record
- Registry ID
- NCT00002211
- Conditions
- HIV Infections
- Interventions
- Nelfinavir mesylate; Delavirdine mesylate; Stavudine; Didanosine
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 160
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionNelfinavir mesylate; Delavirdine mesylate; Stavudine; DidanosinePhaseNot applicableRegistry statusCompletedIndinavir Plus Efavirenz Plus Adefovir Dipivoxil in HIV-Infected Patients Who Have Not Had Success With Nelfinavir
NCT00002220
Registered record
- Registry ID
- NCT00002220
- Conditions
- HIV Infections
- Interventions
- Indinavir sulfate; Efavirenz; Levocarnitine; Adefovir dipivoxil
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionIndinavir sulfate; Efavirenz; Levocarnitine; Adefovir dipivoxilPhasePhase 3Registry statusCompletedA Study of 141W94 in Combination With Other Anti-HIV Drugs
NCT00002372
Registered record
- Registry ID
- NCT00002372
- Conditions
- HIV Infections
- Interventions
- Indinavir sulfate; Amprenavir; Nelfinavir mesylate; Saquinavir
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 48
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionIndinavir sulfate; Amprenavir; Nelfinavir mesylate; SaquinavirPhasePhase 1Registry statusCompletedA Study of Saquinavir Soft Gelatin Capsules Combined With Other Anti-HIV Drugs in HIV-1 Infected Patients
NCT00002374
Registered record
- Registry ID
- NCT00002374
- Conditions
- HIV Infections
- Interventions
- Ritonavir; Nelfinavir mesylate; Saquinavir; Stavudine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionRitonavir; Nelfinavir mesylate; Saquinavir; StavudinePhasePhase 3Registry statusCompleted