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AMR Drug RepurposingSmart Screeningresearch prototype

Cholecalciferol

FDA-approved product (solution, intravenous).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Cholecalciferol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Iron deficiency anemia
  • Osteoporosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin d and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli23.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis35.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cholecalciferol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cholecalciferol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Quality of Life in Postmenopausal Women With Osteoporosis

    NCT03970902 · start 2019-07-01

    Registered record
    Registry ID
    NCT03970902
    Conditions
    Postmenopausal Osteoporosis
    Interventions
    Integrated Osteoporosis Care; Care As Usual
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-07-01
    Completion
    2022-04-01
    Enrolment
    239

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostmenopausal Osteoporosis
    InterventionIntegrated Osteoporosis Care; Care As Usual
    PhaseNot recorded
    Registry statusCompleted

  • Vitamin D Supplementation in Children With Sickle Cell Disease

    NCT03417947 · start 2018-11-30

    Registered record
    Registry ID
    NCT03417947
    Conditions
    Sickle Cell Disease
    Interventions
    Vitamin D bolus; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-11-30
    Completion
    2019-09-30
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle Cell Disease
    InterventionVitamin D bolus; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Vitamin D Status Among Competitive Female Gymnast and Swimmers After Winter Time

    NCT03584256 · start 2018-04-05

    Registered record
    Registry ID
    NCT03584256
    Conditions
    Vitamin D Deficiency; Injuries; Cardiovascular Risk Factor; Nutritional Deficiency
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-04-05
    Completion
    2018-04-06
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Injuries; Cardiovascular Risk Factor; Nutritional Deficiency
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Vitamin D Supplementation to Prevent Vitamin D Deficiency for Children With Epilepsy

    NCT03536845 · start 2018-01-01

    Registered record
    Registry ID
    NCT03536845
    Conditions
    Epilepsy; Vitamin D Deficiency
    Interventions
    Vitamin D 3
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-01-01
    Completion
    2021-08-01
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy; Vitamin D Deficiency
    InterventionVitamin D 3
    PhasePhase 3
    Registry statusCompleted

  • Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial

    NCT02007837 · start 2018-01

    Registered record
    Registry ID
    NCT02007837
    Conditions
    Pregnancy Induced Hypertension
    Interventions
    Combined aspirin and multinutrient supplement; Daily text reminder text messages
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2018-01
    Completion
    2018-08
    Enrolment
    440

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Induced Hypertension
    InterventionCombined aspirin and multinutrient supplement; Daily text reminder text messages
    PhasePhase 3
    Registry statusUnknown

  • Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study

    NCT03401619 · start 2017-09-21

    Registered record
    Registry ID
    NCT03401619
    Conditions
    Osteoporosis，Neurological Disorders
    Interventions
    Exercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al.
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2017-09-21
    Completion
    2027-09-22
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoporosis，Neurological Disorders
    InterventionExercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al.
    PhaseNot recorded
    Registry statusActive not recruiting

  • Impact of Correction of Vitamin D Deficiency in Oxidative Stress in Patients With Prediabetes (VICOX)

    NCT03356873 · start 2017-09-01

    Registered record
    Registry ID
    NCT03356873
    Conditions
    Vitamin D Deficiency; Glucose Intolerance; Oxidative Stress; Insulin Resistance
    Interventions
    Vitamin D; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2017-09-01
    Completion
    2022-07-18
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Glucose Intolerance; Oxidative Stress; Insulin Resistance
    InterventionVitamin D; Placebo
    PhaseNot applicable
    Registry statusTerminated

  • The Effect of Combinatorial Nutritional Supplementation on Immune Function in Healthy Older Adults

    NCT02876315 · start 2016-12

    Registered record
    Registry ID
    NCT02876315
    Conditions
    Vitamin D Deficiency
    Interventions
    Redoxon VI; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-12
    Completion
    2019-12
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionRedoxon VI; placebo
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Calcifediol (Hy.D 25 SD/S) and Vitamin D3 on Muscle Strength in a Frail Elderly Population

    NCT02349282 · start 2014-12

    Registered record
    Registry ID
    NCT02349282
    Conditions
    Deficiency, Vitamin D; Elderly, Frail
    Interventions
    Calcifediol 10ug/day; Vitamin D3 20ug/day; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-12
    Completion
    2015-12
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDeficiency, Vitamin D; Elderly, Frail
    InterventionCalcifediol 10ug/day; Vitamin D3 20ug/day; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • D-Light Intervention

    NCT02495584 · start 2014-09

    Registered record
    Registry ID
    NCT02495584
    Conditions
    25-hydroxyvitamin D Concentration (Vitamin D Status)
    Interventions
    Fortified milk (10µg vitamin D3); Unfortified milk (placebo); 10µg vitamin D3 supplement; Placebo supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-09
    Completion
    2015-10
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    Condition25-hydroxyvitamin D Concentration (Vitamin D Status)
    InterventionFortified milk (10µg vitamin D3); Unfortified milk (placebo); 10µg vitamin D3 supplement; Placebo supplement
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Vitamin D3 Versus 25OHD3 on Mineral Metabolism and Immune Function

    NCT02091219 · start 2014-06

    Registered record
    Registry ID
    NCT02091219
    Conditions
    Vitamin D Deficiency
    Interventions
    Vitamin D; 25(OH)D3
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2014-06
    Completion
    2019-12-07
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionVitamin D; 25(OH)D3
    PhaseEarly phase 1
    Registry statusCompleted

  • Effect of Vitamin D as Adjunctive Therapy in Patients With Pulmonary Evolution Tuberculosis

    NCT02464683 · start 2014-04

    Registered record
    Registry ID
    NCT02464683
    Conditions
    Pulmonary Tuberculosis
    Interventions
    VitaminD
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-04
    Completion
    2016-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionVitaminD
    PhasePhase 4
    Registry statusUnknown

  • Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome

    NCT02026518 · start 2014-01

    Registered record
    Registry ID
    NCT02026518
    Conditions
    Irritable Bowel Disease
    Interventions
    Soy isoflavones; cholecalciferol; Placebo of soy isoflavones; placebo of cholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-01
    Completion
    2014-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIrritable Bowel Disease
    InterventionSoy isoflavones; cholecalciferol; Placebo of soy isoflavones; placebo of cholecalciferol
    PhasePhase 4
    Registry statusCompleted

  • Vitamin D Supplementation in Cirrhotic Patients

    NCT02009748 · start 2013-12

    Registered record
    Registry ID
    NCT02009748
    Conditions
    Cirrhosis; Vitamin D Deficiency
    Interventions
    Vitamin D supplementation; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-12
    Completion
    2015-06
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCirrhosis; Vitamin D Deficiency
    InterventionVitamin D supplementation; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Comparison of Absorption of Vitamin D in Cystic Fibrosis

    NCT01880346 · start 2013-10

    Registered record
    Registry ID
    NCT01880346
    Conditions
    Cystic Fibrosis
    Interventions
    Vitamin D Powder; Vitamin D Oil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-10
    Completion
    2015-10
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis
    InterventionVitamin D Powder; Vitamin D Oil
    PhasePhase 4
    Registry statusCompleted