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AMR Drug RepurposingSmart Screeningresearch prototype

Fluconazole

FDA-approved product (tablet, oral), marketed as Diflucan, Diflucan In Dextrose 5% In Plastic Container, Diflucan In Sodium Chloride 0.9% and 5 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Fluconazole
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Candidiasis
  • Cryptococcal meningitis
  • Urinary tract infection
  • Vulvovaginal candidiasis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Imidazole and triazole derivatives; Triazole and tetrazole derivatives
FDA pharmacologic class
Azole Antifungal FDA label ↗
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC D01AC15; WHO ATC J02AC01; FDA class Azole Antifungal

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA38.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli25.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae15.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Fluconazole in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Fluconazole with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Safety of Fluconazole Treatment of Premature and Full-term Newborn Infants

    NCT02079298 · start 2014-04

    Registered record
    Registry ID
    NCT02079298
    Conditions
    Ductus Arteriosis, Patent; Bacterial Infections and Mycoses
    Interventions
    Treatment with fluconazole.; 2. Treatment with both fluconazole and Ibuprofen.; 3. Treatment with ibuprofen.; 4. No treatment with either fluconazole nor ibuprofen.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-04
    Completion
    2015-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDuctus Arteriosis, Patent; Bacterial Infections and Mycoses
    InterventionTreatment with fluconazole.; 2. Treatment with both fluconazole and Ibuprofen.; 3. Treatment with ibuprofen.; 4. No treatment with either fluconazole nor ibuprofen.
    PhasePhase 4
    Registry statusCompleted

  • Cedar Honey in Oral Lichen Planus

    NCT01974414 · start 2011-09

    Registered record
    Registry ID
    NCT01974414
    Conditions
    Erosive and Atrophic Oral Lichen Planus
    Interventions
    orally administered cedar honey
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2011-09
    Completion
    2012-12
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErosive and Atrophic Oral Lichen Planus
    Interventionorally administered cedar honey
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis

    NCT01455246 · start 2010-10

    Registered record
    Registry ID
    NCT01455246
    Conditions
    Cirrhosis; Ascites; Nosocomial Spontaneous Bacterial Peritonitis
    Interventions
    Daptomycin + Meropenem; Ceftazidime
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2010-10
    Completion
    2014-07
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCirrhosis; Ascites; Nosocomial Spontaneous Bacterial Peritonitis
    InterventionDaptomycin + Meropenem; Ceftazidime
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Hematopoietic Stem Cell Transplantation in Type 1 Diabetes Mellitus

    NCT01121029 · start 2010-05

    Registered record
    Registry ID
    NCT01121029
    Conditions
    Type 1 Diabetes Mellitus
    Interventions
    Autologous hematopoietic stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2010-05
    Completion
    2012-12
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 1 Diabetes Mellitus
    InterventionAutologous hematopoietic stem cell transplantation
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • CYP2C9 Activity Evaluated With a Simple Finger Prick

    NCT01026714 · start 2009-11

    Registered record
    Registry ID
    NCT01026714
    Conditions
    Healthy Volunteers
    Interventions
    flurbiprofen; flurbiprofen, rifampicin; flurbiprofen + fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2009-11
    Completion
    2010-08
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    Interventionflurbiprofen; flurbiprofen, rifampicin; flurbiprofen + fluconazole
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study

    NCT00689338 · start 2008-07

    Registered record
    Registry ID
    NCT00689338
    Conditions
    Invasive Candidiasis
    Interventions
    Anidulafungin; Fluconazole; Voriconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2010-05
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Candidiasis
    InterventionAnidulafungin; Fluconazole; Voriconazole
    PhasePhase 3
    Registry statusCompleted

  • Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures

    NCT01524081 · start 2008-07

    Registered record
    Registry ID
    NCT01524081
    Conditions
    Acute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    Interventions
    Metronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2011-11
    Enrolment
    187

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    InterventionMetronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group

    NCT00634166 · start 2007-09

    Registered record
    Registry ID
    NCT00634166
    Conditions
    Burns
    Interventions
    Sulfamylon® For 5 % Topical Solution; Topical Antimicrobial/Antifungal Medications
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-09
    Completion
    2014-04
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns
    InterventionSulfamylon® For 5 % Topical Solution; Topical Antimicrobial/Antifungal Medications
    PhasePhase 4
    Registry statusTerminated

  • Study: Treatment of Relapsed Lymphoid Malignancies With an Anti-Angiogenic Approach

    NCT00250718 · start 2004-10

    Registered record
    Registry ID
    NCT00250718
    Conditions
    Non-Hodgkin's Lymphoma; Cancer
    Interventions
    Vincristine; VP-16; Rituximab; Dexamethasone; Levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2004-10
    Completion
    2014-05
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-Hodgkin's Lymphoma; Cancer
    InterventionVincristine; VP-16; Rituximab; Dexamethasone +1 more
    PhasePhase 2
    Registry statusTerminated

  • Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemia

    NCT00189709 · start 2004-08

    Registered record
    Registry ID
    NCT00189709
    Conditions
    Invasive Candidiasis; Candidemia
    Interventions
    Micafungin; fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-08
    Completion
    2006-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Candidiasis; Candidemia
    InterventionMicafungin; fluconazole
    PhasePhase 3
    Registry statusCompleted

  • Efficacy Vulvovaginitis Candida

    NCT00199264 · start 2004-06

    Registered record
    Registry ID
    NCT00199264
    Conditions
    Candidiasis Vulvaginitis
    Interventions
    Albaconazole oral solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2004-06
    Completion
    2004-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandidiasis Vulvaginitis
    InterventionAlbaconazole oral solution
    PhasePhase 2
    Registry statusTerminated

  • Reducing Vaginal Infections in Women

    NCT00170430 · start 2003-05

    Registered record
    Registry ID
    NCT00170430
    Conditions
    Bacterial Diseases; Other Mycoses; Sexually Transmitted Infection
    Interventions
    Fluconazole; Metronizadole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-05
    Completion
    2006-12
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Diseases; Other Mycoses; Sexually Transmitted Infection
    InterventionFluconazole; Metronizadole
    PhasePhase 3
    Registry statusCompleted

  • Anidulafungin Versus Fluconazole in the Treatment of Candidemia

    NCT00058682 · start 2003-04

    Registered record
    Registry ID
    NCT00058682
    Conditions
    Candida; Candidiasis
    Interventions
    Anidulafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-04
    Completion
    2005-01
    Enrolment
    248

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandida; Candidiasis
    InterventionAnidulafungin
    PhasePhase 3
    Registry statusCompleted

  • Prediction of Drug Interactions With CYP2C9 Substrates

    NCT00226538 · start 1999-08

    Registered record
    Registry ID
    NCT00226538
    Conditions
    Healthy Volunteers
    Interventions
    Phenytoin; Rifampicin; Diclophenac; Fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1999-08
    Completion
    Not recorded
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionPhenytoin; Rifampicin; Diclophenac; Fluconazole
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone

    NCT00000788

    Registered record
    Registry ID
    NCT00000788
    Conditions
    Candidiasis; HIV Infections
    Interventions
    Methadone hydrochloride; Fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1994-06
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandidiasis; HIV Infections
    InterventionMethadone hydrochloride; Fluconazole
    PhasePhase 1
    Registry statusCompleted