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AMR Drug RepurposingSmart Screeningresearch prototype

Permethrin

FDA-approved product (lotion, topical), marketed as Elimite, Nix, Permethrin.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Permethrin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Parasitic infection

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Pyrethrines, incl. synthetic compounds
FDA pharmacologic class
Pyrethroid FDA label ↗
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC P03AC04; WHO ATC P03AC54

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA41.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis48.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Permethrin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Permethrin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Comparative Study Between Topical Permethrin 5% and Oral Ivermectin for the Treatment of Scabies

    NCT05362513 · start 2021-06-01

    Registered record
    Registry ID
    NCT05362513
    Conditions
    Scabies
    Interventions
    Ivermectin Tablets; Permethrin Cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2021-06-01
    Completion
    2021-11-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScabies
    InterventionIvermectin Tablets; Permethrin Cream
    PhasePhase 1
    Registry statusCompleted

  • Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Mozambique

    NCT04716387 · start 2020-08-18

    Registered record
    Registry ID
    NCT04716387
    Conditions
    Malaria
    Interventions
    Standard LLIN; Piperonyl butoxide ITN; Pyriproxyfen ITN; Chlorfenapyr ITN
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-08-18
    Completion
    2022-09-30
    Enrolment
    8,726

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionStandard LLIN; Piperonyl butoxide ITN; Pyriproxyfen ITN; Chlorfenapyr ITN
    PhaseNot recorded
    Registry statusCompleted

  • Adaptive Interventions for Optimizing Malaria Control: a Cluster-Randomized SMART Trial

    NCT04182126 · start 2019-12-01

    Registered record
    Registry ID
    NCT04182126
    Conditions
    LLIN, PBO LLIN, IRS, Larviciding
    Interventions
    Regular long-lasting insecticidal nets; LLIN plus Piperonyl butoxide-treated LLIN; Long-lasting microbial larvicide; Indoor residual spraying with micro-encapsulated pirimiphos-methyl or other insecticides
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-12-01
    Completion
    2024-08-31
    Enrolment
    122,872

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLLIN, PBO LLIN, IRS, Larviciding
    InterventionRegular long-lasting insecticidal nets; LLIN plus Piperonyl butoxide-treated LLIN; Long-lasting microbial larvicide; Indoor residual spraying with micro-encapsulated pirimiphos-methyl or other insecticides
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Three Novel Bi-treated Long Lasting Insecticidal Nets

    NCT03554616 · start 2019-02-01

    Registered record
    Registry ID
    NCT03554616
    Conditions
    Malaria; Anaemia
    Interventions
    Chlorfenapyr LLIN; pyriproxyfen LLIN; Piperonyl butoxide LLIN; Standard LLIN
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-02-01
    Completion
    2023-02-01
    Enrolment
    4,200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Anaemia
    InterventionChlorfenapyr LLIN; pyriproxyfen LLIN; Piperonyl butoxide LLIN; Standard LLIN
    PhaseNot applicable
    Registry statusCompleted

  • A Bioequivalence Study With Clinical Endpoints to Evaluate the Safety and Therapeutic Equivalence of Permethrin Cream 5% & Elimite™ in Subjects With Scabies

    NCT03973775 · start 2018-04-10

    Registered record
    Registry ID
    NCT03973775
    Conditions
    Scabies
    Interventions
    Permethrin Cream 5%
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-04-10
    Completion
    2018-12-06
    Enrolment
    126

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScabies
    InterventionPermethrin Cream 5%
    PhasePhase 3
    Registry statusCompleted

  • Field Efficacy Of Insecticide Treated Uniforms And Skin Repellents for Malaria Prevention

    NCT02938975 · start 2017-11

    Registered record
    Registry ID
    NCT02938975
    Conditions
    Malaria
    Interventions
    Ultra 30 Insect Repellent Lotion (30% Lipo DEET); Permethrin Factory-Treated Army Combat Uniforms; Placebo lotion; Army combat uniform
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2017-11
    Completion
    2019-06
    Enrolment
    1,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionUltra 30 Insect Repellent Lotion (30% Lipo DEET); Permethrin Factory-Treated Army Combat Uniforms; Placebo lotion; Army combat uniform
    PhasePhase 3
    Registry statusUnknown

  • Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies

    NCT02841215 · start 2017-10-11

    Registered record
    Registry ID
    NCT02841215
    Conditions
    Gale; Severe Forms of Scabies; Oral Parasitic Drug; Ivermectin
    Interventions
    Ivermectin 200 µg/kg; Ivermectin 400 µg/kg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-10-11
    Completion
    2022-01-12
    Enrolment
    133

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGale; Severe Forms of Scabies; Oral Parasitic Drug; Ivermectin
    InterventionIvermectin 200 µg/kg; Ivermectin 400 µg/kg
    PhasePhase 3
    Registry statusCompleted

  • Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies

    NCT03178942 · start 2017-06-01

    Registered record
    Registry ID
    NCT03178942
    Conditions
    Scabies
    Interventions
    Permethrin Cream, 5%; Elimite™ Cream (permethrin) 5%
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-06-01
    Completion
    2017-11-11
    Enrolment
    254

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScabies
    InterventionPermethrin Cream, 5%; Elimite™ Cream (permethrin) 5%
    PhasePhase 3
    Registry statusCompleted

  • The Efficacy of Permethrin 5%, Fusidic Acid 1% and Synthomycine 5% for Demodex - Blepharitis

    NCT03105505 · start 2017-04-28

    Registered record
    Registry ID
    NCT03105505
    Conditions
    Inflammation of the Eyelids
    Interventions
    Permethrin 5%; Synthomycine 5%; Fusidic Acid 1% M/R Eye Drops
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-04-28
    Completion
    2018-09
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammation of the Eyelids
    InterventionPermethrin 5%; Synthomycine 5%; Fusidic Acid 1% M/R Eye Drops
    PhasePhase 4
    Registry statusUnknown

  • Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies.

    NCT02978508 · start 2016-11

    Registered record
    Registry ID
    NCT02978508
    Conditions
    Scabies
    Interventions
    Permethrin Cream, 5%; Elimite
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-11
    Completion
    2017-05
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScabies
    InterventionPermethrin Cream, 5%; Elimite
    PhasePhase 3
    Registry statusCompleted

  • Tick-borne Illness and Clothing Study of Rhode Island

    NCT02613585 · start 2016-02

    Registered record
    Registry ID
    NCT02613585
    Conditions
    Tick Bites; Tick-borne Diseases
    Interventions
    Permethrin Impregnated Clothing
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-02
    Completion
    2020-12
    Enrolment
    135

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTick Bites; Tick-borne Diseases
    InterventionPermethrin Impregnated Clothing
    PhaseNot applicable
    Registry statusCompleted

  • Multilevel Intervention for Preventing Men's Use of Violence in Urban South Africa (Sonke CHANGE Trial)

    NCT02823288 · start 2016-02

    Registered record
    Registry ID
    NCT02823288
    Conditions
    Domestic Violence; Sexual Assault and Rape; Masculinity
    Interventions
    Sonke CHANGE intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-02
    Completion
    2018-08
    Enrolment
    2,603

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDomestic Violence; Sexual Assault and Rape; Masculinity
    InterventionSonke CHANGE intervention
    PhaseNot applicable
    Registry statusUnknown

  • Malaria Elimination Pilot Study in Military Forces in Cambodia

    NCT02653898 · start 2016-01

    Registered record
    Registry ID
    NCT02653898
    Conditions
    Malaria; Parasitic Diseases
    Interventions
    DHA-PIP; Primaquine; Artesunate + Mefloquine; Permethrin (Insecticide treated uniform)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-01
    Completion
    2021-12
    Enrolment
    1,050

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Parasitic Diseases
    InterventionDHA-PIP; Primaquine; Artesunate + Mefloquine; Permethrin (Insecticide treated uniform)
    PhasePhase 4
    Registry statusUnknown

  • A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TB

    NCT02333799 · start 2015-03

    Registered record
    Registry ID
    NCT02333799
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Bedaquiline; PA-824; Linezolid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-03
    Completion
    2020-08-03
    Enrolment
    109

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionBedaquiline; PA-824; Linezolid
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product

    NCT02288637 · start 2014-09

    Registered record
    Registry ID
    NCT02288637
    Conditions
    Malaria; Anaemia
    Interventions
    Olyset Plus LLIN; Conventional Olyset LLIN; IRS
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-09
    Completion
    2018-04
    Enrolment
    3,840

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Anaemia
    InterventionOlyset Plus LLIN; Conventional Olyset LLIN; IRS
    PhaseNot applicable
    Registry statusCompleted