Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Aminocaproic Acid

FDA-approved product (tablet, oral), marketed as Amicar, Aminocaproic, Aminocaproic Acid and 1 more.

Registered studies
36
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Aminocaproic Acid
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Amino acids
FDA pharmacologic class
Antifibrinolytic Agent FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Aminocaproic Acid, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA17.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli8.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae19.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis15.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

36registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Aminocaproic Acid in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Aminocaproic Acid with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

    NCT07644923 · start 2026-08-01

    Registered record
    Registry ID
    NCT07644923
    Conditions
    Postoperative Pain
    Interventions
    Bupivacaine; Lidocaine; Thrombin; Tranexamic acid; Aminocaproic acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-08-01
    Completion
    2029-02-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionBupivacaine; Lidocaine; Thrombin; Tranexamic acid +1 more
    PhasePhase 4
    Registry statusNot yet recruiting

  • Extended Perioperative Administration of Fibrinolysis Inhibitors After Cardiac Surgery

    NCT06493227 · start 2024-08-01

    Registered record
    Registry ID
    NCT06493227
    Conditions
    Thoracic Surgery; Heart Diseases; Fibrinolysis Shutdown
    Interventions
    No routine fibrinolysis inhibitors after surgery; Routine fibrinolysis inhibitors after surgery
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-08-01
    Completion
    2026-06-01
    Enrolment
    1,373

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThoracic Surgery; Heart Diseases; Fibrinolysis Shutdown
    InterventionNo routine fibrinolysis inhibitors after surgery; Routine fibrinolysis inhibitors after surgery
    PhaseNot applicable
    Registry statusRecruiting

  • Intrawound Administration of Vancomycin in TKA

    NCT05338021 · start 2022-05-25

    Registered record
    Registry ID
    NCT05338021
    Conditions
    Knee Osteoarthritis
    Interventions
    Intrawound administration of vancomycin after closure of the arthrotomy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-05-25
    Completion
    2022-09-07
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKnee Osteoarthritis
    InterventionIntrawound administration of vancomycin after closure of the arthrotomy
    PhaseNot applicable
    Registry statusCompleted

  • EACA VS CCA in Postoperative Evaluation of Middle Ear Pressure

    NCT05291312 · start 2022-05-01

    Registered record
    Registry ID
    NCT05291312
    Conditions
    Adenoid Hypertrophy
    Interventions
    Adenoidectomy with endoscopic assisted coblation (EACA) and Adenoidectomy with conventional curettage (CCA)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-05-01
    Completion
    2024-12-01
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenoid Hypertrophy
    InterventionAdenoidectomy with endoscopic assisted coblation (EACA) and Adenoidectomy with conventional curettage (CCA)
    PhaseNot applicable
    Registry statusUnknown

  • Intrawound Administration of Vancomycin in THA

    NCT05338008 · start 2022-05-01

    Registered record
    Registry ID
    NCT05338008
    Conditions
    Hip
    Interventions
    Intrawound administration of vancomycin after closure of the arthrotomy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-05-01
    Completion
    2022-12-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip
    InterventionIntrawound administration of vancomycin after closure of the arthrotomy
    PhaseNot applicable
    Registry statusCompleted

  • Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

    NCT04814433 · start 2021-03-24

    Registered record
    Registry ID
    NCT04814433
    Conditions
    Opioid Pain Medication
    Interventions
    Tranexamic acid; Aminocaproic acid; Recombinant Human Thrombin; Lidocaine Hydrochloride with Epinephrine; Bupivacaine Hydrochloride with Epinephrine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2021-03-24
    Completion
    2023-07-10
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Pain Medication
    InterventionTranexamic acid; Aminocaproic acid; Recombinant Human Thrombin; Lidocaine Hydrochloride with Epinephrine +1 more
    PhasePhase 4
    Registry statusTerminated

  • Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    NCT04278404 · start 2020-03-05

    Registered record
    Registry ID
    NCT04278404
    Conditions
    Coronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension; Pain; Hyperphosphatemia; Primary Hyperaldosteronism; Edema; Hypokalemia; Heart Failure; Hemophilia; Menorrhagia; Insomnia; Pneumonia; Skin Infection; Arrythmia; Asthma in Children; Bronchopulmonary Dysplasia; Adrenal Insufficiency; Fibrinolysis; Hemorrhage; Attention Deficit Hyperactivity Disorder; Multisystem Inflammatory Syndrome in Children (MIS-C); Kawasaki Disease; Coagulation Disorder; Down Syndrome
    Interventions
    The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2020-03-05
    Completion
    2026-12
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension +22 more
    InterventionThe POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusRecruiting

  • Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss After Total Hip Replacement

    NCT04187014 · start 2020-02-06

    Registered record
    Registry ID
    NCT04187014
    Conditions
    Blood Loss, Surgical
    Interventions
    Aminocaproic Acid 1000Mg Tab; Tranexamic acid tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2020-02-06
    Completion
    2021-04-26
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood Loss, Surgical
    InterventionAminocaproic Acid 1000Mg Tab; Tranexamic acid tablets
    PhasePhase 2
    Registry statusCompleted

  • Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement.

    NCT03365999 · start 2017-10-15

    Registered record
    Registry ID
    NCT03365999
    Conditions
    Knee Osteoarthritis; Blood Clot; Transfusion Related Complication; Blood Loss
    Interventions
    Oral Tranexamic Acid; Oral Aminocaproic Acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-10-15
    Completion
    2019-07-01
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKnee Osteoarthritis; Blood Clot; Transfusion Related Complication; Blood Loss
    InterventionOral Tranexamic Acid; Oral Aminocaproic Acid
    PhasePhase 2
    Registry statusCompleted

  • Activated Factor Seven in Traumatic Retro Peritoneal Hematoma

    NCT04424563 · start 2017-05-05

    Registered record
    Registry ID
    NCT04424563
    Conditions
    Traumatic Bleeding
    Interventions
    ventilators; aminocaproic acid; Novo Seven
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-05-05
    Completion
    2019-12-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTraumatic Bleeding
    Interventionventilators; aminocaproic acid; Novo Seven
    PhaseNot recorded
    Registry statusCompleted

  • Management of Intracerebral Hemorrhage With Aminocaproic Acid - Pilot Study

    NCT02639819 · start 2016-06

    Registered record
    Registry ID
    NCT02639819
    Conditions
    Intracerebral Hemorrhage
    Interventions
    ɛ-Aminocaproic Acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2016-06
    Completion
    2017-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Hemorrhage
    Interventionɛ-Aminocaproic Acid
    PhasePhase 1
    Registry statusWithdrawn

  • A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery

    NCT02656472 · start 2016-02

    Registered record
    Registry ID
    NCT02656472
    Conditions
    Pediatric Cardiac Surgery; Complication of Extracorporeal Circulation
    Interventions
    Tranexamic acid; Epsilon Aminocaproic Acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-02
    Completion
    2017-04
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric Cardiac Surgery; Complication of Extracorporeal Circulation
    InterventionTranexamic acid; Epsilon Aminocaproic Acid
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Intravenous EACA on Blood Loss and Transfusion Requirements After Bilateral VRO

    NCT02257580 · start 2015-04-01

    Registered record
    Registry ID
    NCT02257580
    Conditions
    E-Aminocaproic Acid; Bilateral Varus Rotational Osteotomy
    Interventions
    E-Aminocaproic acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04-01
    Completion
    2020-10-26
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionE-Aminocaproic Acid; Bilateral Varus Rotational Osteotomy
    InterventionE-Aminocaproic acid
    PhasePhase 4
    Registry statusCompleted

  • Determination of the Minimal Concentration of Antifibrinolytics Required to Inhibit t-PA-activated Fibrinolysis

    NCT02352675 · start 2015-04

    Registered record
    Registry ID
    NCT02352675
    Conditions
    Congenital Heart Disease; Fibrinolysis; Rotational Thromboelastometry
    Interventions
    Intraoperative Blood Sample
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-04
    Completion
    2016-03
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCongenital Heart Disease; Fibrinolysis; Rotational Thromboelastometry
    InterventionIntraoperative Blood Sample
    PhaseNot recorded
    Registry statusCompleted

  • TXA vs. Amicar in Total Knee and Hip Arthroplasty

    NCT02030821 · start 2015-01

    Registered record
    Registry ID
    NCT02030821
    Conditions
    Blood Loss; Hip Arthritis; Knee Arthritis
    Interventions
    Amicar; TXA
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-01
    Completion
    2017-11-12
    Enrolment
    246

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood Loss; Hip Arthritis; Knee Arthritis
    InterventionAmicar; TXA
    PhasePhase 4
    Registry statusCompleted