Aminocaproic Acid
FDA-approved product (tablet, oral), marketed as Amicar, Aminocaproic, Aminocaproic Acid and 1 more.
- Registered studies
- 36
- Lab records
- 0
- Pathogens at ≥40%
- 0 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBL- WHO therapeutic group
- Amino acids
- FDA pharmacologic class
- Antifibrinolytic Agent FDA label ↗
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
No supported pathogen reaches ≥40% AI-predicted activity for Aminocaproic Acid, so it is not among the repurposing candidates. Its predictions are shown below.
AI-predicted activity
AI prediction · nothing measured- MRSA17.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli8.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae19.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis15.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
36registered studies name this medicine, for any condition. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Aminocaproic Acid with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- FurazolidoneExisting use: Other antiinfectives and antiseptics91.4% AI-predicted activityagainst M. tuberculosisLab records exist49 registered studies
- TriflupromazineExisting use: Psychosis90.6% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- ValdecoxibExisting use: Dysmenorrhea, Osteoarthritis, Rheumatic disease and 1 more88.6% AI-predicted activityagainst M. tuberculosisLab records exist31 registered studies
- CelecoxibExisting use: Ankylosing spondylitis, Cancer, Colorectal neoplasm and 15 more87.6% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Dorzolamide HydrochlorideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma86.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- MethazolamideExisting use: Glaucoma, Open-angle glaucoma85.6% AI-predicted activityagainst M. tuberculosisLab records exist11 registered studies
- AcetazolamideExisting use: Altitude sickness, Angle-closure glaucoma, Congestive heart failure and 5 more85.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Trifluoperazine HydrochlorideExisting use: Anxiety disorder, Mental or behavioural disorder, Psychosis and 1 more84.6% AI-predicted activityagainst M. tuberculosis1 registered study
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives84.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- NitrofurazoneExisting use: Eye infection, Leishmaniasis, Trypanosomiasis84.0% AI-predicted activityagainst M. tuberculosis8 registered studies
- BrinzolamideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma83.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- ZonisamideExisting use: Epilepsy, Focal-onset seizure, Partial epilepsy and 1 more82.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
NCT07644923 · start 2026-08-01
Registered record
- Registry ID
- NCT07644923
- Conditions
- Postoperative Pain
- Interventions
- Bupivacaine; Lidocaine; Thrombin; Tranexamic acid; Aminocaproic acid
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Not yet recruiting
- Start
- 2026-08-01
- Completion
- 2029-02-01
- Enrolment
- 40
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPostoperative PainInterventionBupivacaine; Lidocaine; Thrombin; Tranexamic acid +1 morePhasePhase 4Registry statusNot yet recruitingExtended Perioperative Administration of Fibrinolysis Inhibitors After Cardiac Surgery
NCT06493227 · start 2024-08-01
Registered record
- Registry ID
- NCT06493227
- Conditions
- Thoracic Surgery; Heart Diseases; Fibrinolysis Shutdown
- Interventions
- No routine fibrinolysis inhibitors after surgery; Routine fibrinolysis inhibitors after surgery
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Recruiting
- Start
- 2024-08-01
- Completion
- 2026-06-01
- Enrolment
- 1,373
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionThoracic Surgery; Heart Diseases; Fibrinolysis ShutdownInterventionNo routine fibrinolysis inhibitors after surgery; Routine fibrinolysis inhibitors after surgeryPhaseNot applicableRegistry statusRecruitingIntrawound Administration of Vancomycin in TKA
NCT05338021 · start 2022-05-25
Registered record
- Registry ID
- NCT05338021
- Conditions
- Knee Osteoarthritis
- Interventions
- Intrawound administration of vancomycin after closure of the arthrotomy
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2022-05-25
- Completion
- 2022-09-07
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionKnee OsteoarthritisInterventionIntrawound administration of vancomycin after closure of the arthrotomyPhaseNot applicableRegistry statusCompletedEACA VS CCA in Postoperative Evaluation of Middle Ear Pressure
NCT05291312 · start 2022-05-01
Registered record
- Registry ID
- NCT05291312
- Conditions
- Adenoid Hypertrophy
- Interventions
- Adenoidectomy with endoscopic assisted coblation (EACA) and Adenoidectomy with conventional curettage (CCA)
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2022-05-01
- Completion
- 2024-12-01
- Enrolment
- 70
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAdenoid HypertrophyInterventionAdenoidectomy with endoscopic assisted coblation (EACA) and Adenoidectomy with conventional curettage (CCA)PhaseNot applicableRegistry statusUnknownIntrawound Administration of Vancomycin in THA
NCT05338008 · start 2022-05-01
Registered record
- Registry ID
- NCT05338008
- Conditions
- Hip
- Interventions
- Intrawound administration of vancomycin after closure of the arthrotomy
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2022-05-01
- Completion
- 2022-12-31
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHipInterventionIntrawound administration of vancomycin after closure of the arthrotomyPhaseNot applicableRegistry statusCompletedEvaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
NCT04814433 · start 2021-03-24
Registered record
- Registry ID
- NCT04814433
- Conditions
- Opioid Pain Medication
- Interventions
- Tranexamic acid; Aminocaproic acid; Recombinant Human Thrombin; Lidocaine Hydrochloride with Epinephrine; Bupivacaine Hydrochloride with Epinephrine
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Terminated
- Start
- 2021-03-24
- Completion
- 2023-07-10
- Enrolment
- 46
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionOpioid Pain MedicationInterventionTranexamic acid; Aminocaproic acid; Recombinant Human Thrombin; Lidocaine Hydrochloride with Epinephrine +1 morePhasePhase 4Registry statusTerminatedPharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
NCT04278404 · start 2020-03-05
Registered record
- Registry ID
- NCT04278404
- Conditions
- Coronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension; Pain; Hyperphosphatemia; Primary Hyperaldosteronism; Edema; Hypokalemia; Heart Failure; Hemophilia; Menorrhagia; Insomnia; Pneumonia; Skin Infection; Arrythmia; Asthma in Children; Bronchopulmonary Dysplasia; Adrenal Insufficiency; Fibrinolysis; Hemorrhage; Attention Deficit Hyperactivity Disorder; Multisystem Inflammatory Syndrome in Children (MIS-C); Kawasaki Disease; Coagulation Disorder; Down Syndrome
- Interventions
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Recruiting
- Start
- 2020-03-05
- Completion
- 2026-12
- Enrolment
- 5,000
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCoronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension +22 moreInterventionThe POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:PhaseNot recordedRegistry statusRecruitingOral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss After Total Hip Replacement
NCT04187014 · start 2020-02-06
Registered record
- Registry ID
- NCT04187014
- Conditions
- Blood Loss, Surgical
- Interventions
- Aminocaproic Acid 1000Mg Tab; Tranexamic acid tablets
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2020-02-06
- Completion
- 2021-04-26
- Enrolment
- 90
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBlood Loss, SurgicalInterventionAminocaproic Acid 1000Mg Tab; Tranexamic acid tabletsPhasePhase 2Registry statusCompletedOral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement.
NCT03365999 · start 2017-10-15
Registered record
- Registry ID
- NCT03365999
- Conditions
- Knee Osteoarthritis; Blood Clot; Transfusion Related Complication; Blood Loss
- Interventions
- Oral Tranexamic Acid; Oral Aminocaproic Acid
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2017-10-15
- Completion
- 2019-07-01
- Enrolment
- 92
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionKnee Osteoarthritis; Blood Clot; Transfusion Related Complication; Blood LossInterventionOral Tranexamic Acid; Oral Aminocaproic AcidPhasePhase 2Registry statusCompletedActivated Factor Seven in Traumatic Retro Peritoneal Hematoma
NCT04424563 · start 2017-05-05
Registered record
- Registry ID
- NCT04424563
- Conditions
- Traumatic Bleeding
- Interventions
- ventilators; aminocaproic acid; Novo Seven
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2017-05-05
- Completion
- 2019-12-30
- Enrolment
- 80
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionTraumatic BleedingInterventionventilators; aminocaproic acid; Novo SevenPhaseNot recordedRegistry statusCompletedManagement of Intracerebral Hemorrhage With Aminocaproic Acid - Pilot Study
NCT02639819 · start 2016-06
Registered record
- Registry ID
- NCT02639819
- Conditions
- Intracerebral Hemorrhage
- Interventions
- ɛ-Aminocaproic Acid
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Withdrawn
- Start
- 2016-06
- Completion
- 2017-12
- Enrolment
- 0
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIntracerebral HemorrhageInterventionɛ-Aminocaproic AcidPhasePhase 1Registry statusWithdrawnA Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery
NCT02656472 · start 2016-02
Registered record
- Registry ID
- NCT02656472
- Conditions
- Pediatric Cardiac Surgery; Complication of Extracorporeal Circulation
- Interventions
- Tranexamic acid; Epsilon Aminocaproic Acid
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2016-02
- Completion
- 2017-04
- Enrolment
- 22
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPediatric Cardiac Surgery; Complication of Extracorporeal CirculationInterventionTranexamic acid; Epsilon Aminocaproic AcidPhasePhase 4Registry statusCompletedThe Effect of Intravenous EACA on Blood Loss and Transfusion Requirements After Bilateral VRO
NCT02257580 · start 2015-04-01
Registered record
- Registry ID
- NCT02257580
- Conditions
- E-Aminocaproic Acid; Bilateral Varus Rotational Osteotomy
- Interventions
- E-Aminocaproic acid
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2015-04-01
- Completion
- 2020-10-26
- Enrolment
- 28
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionE-Aminocaproic Acid; Bilateral Varus Rotational OsteotomyInterventionE-Aminocaproic acidPhasePhase 4Registry statusCompletedDetermination of the Minimal Concentration of Antifibrinolytics Required to Inhibit t-PA-activated Fibrinolysis
NCT02352675 · start 2015-04
Registered record
- Registry ID
- NCT02352675
- Conditions
- Congenital Heart Disease; Fibrinolysis; Rotational Thromboelastometry
- Interventions
- Intraoperative Blood Sample
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2015-04
- Completion
- 2016-03
- Enrolment
- 40
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCongenital Heart Disease; Fibrinolysis; Rotational ThromboelastometryInterventionIntraoperative Blood SamplePhaseNot recordedRegistry statusCompletedTXA vs. Amicar in Total Knee and Hip Arthroplasty
NCT02030821 · start 2015-01
Registered record
- Registry ID
- NCT02030821
- Conditions
- Blood Loss; Hip Arthritis; Knee Arthritis
- Interventions
- Amicar; TXA
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2015-01
- Completion
- 2017-11-12
- Enrolment
- 246
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBlood Loss; Hip Arthritis; Knee ArthritisInterventionAmicar; TXAPhasePhase 4Registry statusCompleted