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AMR Drug RepurposingSmart Screeningresearch prototype

Streptomycin Sulfate

FDA-approved product (injectable, injection), marketed as Streptomycin Sulfate.

Registered studies
32
Lab records
63
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Streptomycin Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Chancroid
  • Granuloma inguinale
  • Infection
  • Pneumonia
  • Septicemic plague
  • Tuberculosis
  • Tularemia
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antibiotics; Streptomycins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01GA01; WHO ATC A07AA04; WHO ATC A07AA54

Repurposing investigation

Streptomycin Sulfate is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA74.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli71.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae75.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis87.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

32registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 4 of 4 lab records
  • K. pneumoniae: measured active in 15 of 15 lab records
  • M. tuberculosis: measured active in 41 of 42 lab records
Open Streptomycin Sulfate in ChEMBL Registered studies below
Show the 63 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Streptomycin Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Evaluation of Viral Replication by Tonate Virus (TONV) and Zika Virus (ZIKV), Within an ex Vivo Trophoblast and Placental Model

    NCT05589012 · start 2023-11-01

    Registered record
    Registry ID
    NCT05589012
    Conditions
    Zika Virus Infection
    Interventions
    Cell line and virus; Infection of human placental culture explants; Determination of viral load in tissues by qRT-PCR
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2023-11-01
    Completion
    2024-04-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionZika Virus Infection
    InterventionCell line and virus; Infection of human placental culture explants; Determination of viral load in tissues by qRT-PCR
    PhaseNot recorded
    Registry statusWithdrawn

  • Comparison of Keloid Volume and Symptoms Reduction Between Intralesional Umbilical-Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide Injection as Keloid Therapy: A Randomised Controlled Trial

    NCT05887804 · start 2021-10-01

    Registered record
    Registry ID
    NCT05887804
    Conditions
    Keloid; Stem Cell
    Interventions
    umbilical cord-derived mesenchymal stem cells (UC-MSC); umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM); Triamcinolone Acetonide (TA)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-10-01
    Completion
    2022-06-09
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeloid; Stem Cell
    Interventionumbilical cord-derived mesenchymal stem cells (UC-MSC); umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM); Triamcinolone Acetonide (TA)
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Intralesian Injection of Umbilical Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide on Type 1:3 Collagen Ratio and Interleukin-10 Levels in Keloid: A Randomised Controlled Trial

    NCT05939817 · start 2021-10-01

    Registered record
    Registry ID
    NCT05939817
    Conditions
    Keloid; Stem Cell
    Interventions
    umbilical cord-derived mesenchymal stem cells (UC-MSC); umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM); Triamcinolone Acetonide (TA)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-10-01
    Completion
    2022-06-09
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeloid; Stem Cell
    Interventionumbilical cord-derived mesenchymal stem cells (UC-MSC); umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM); Triamcinolone Acetonide (TA)
    PhasePhase 4
    Registry statusCompleted

  • Mucosal-Associated Invariant T Cells in Cases of Miscarriage

    NCT04492098 · start 2021-06-01

    Registered record
    Registry ID
    NCT04492098
    Conditions
    Miscarriage
    Interventions
    MAIT cells
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-06-01
    Completion
    2022-12-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMiscarriage
    InterventionMAIT cells
    PhaseNot recorded
    Registry statusCompleted

  • Safety of Sabin Inactivated Poliovirus Vaccine in Adults, Children and Infants and Lot Consistency Immunogenicity, and Safety of the msIPV in 2 Months Old Infants

    NCT05386810 · start 2020-11-05

    Registered record
    Registry ID
    NCT05386810
    Conditions
    Poliomyelitis
    Interventions
    Experimental vaccine; IPV control vaccine; single-person sIPV control vaccine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2020-11-05
    Completion
    2023-07-20
    Enrolment
    1,572

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPoliomyelitis
    InterventionExperimental vaccine; IPV control vaccine; single-person sIPV control vaccine
    PhasePhase 3
    Registry statusCompleted

  • Ciprofloxacin Versus an Aminoglycoside Followed by Ciprofloxacin for Bubonic Plague

    NCT04110340 · start 2020-02-15

    Registered record
    Registry ID
    NCT04110340
    Conditions
    Plague, Bubonic; Plague, Pneumonic
    Interventions
    Ciprofloxacin; Streptomycin; Gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2020-02-15
    Completion
    2025-02-05
    Enrolment
    222

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlague, Bubonic; Plague, Pneumonic
    InterventionCiprofloxacin; Streptomycin; Gentamicin
    PhasePhase 3
    Registry statusCompleted

  • Induced Pluripotent Stem Cells for the Development of Novel Drug Therapies for Inborn Errors of Metabolism (iPSC-IEM)

    NCT04097275 · start 2019-08-01

    Registered record
    Registry ID
    NCT04097275
    Conditions
    Inborn Errors of Metabolism
    Interventions
    Skin biopsy; Withdraw of blood
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2019-08-01
    Completion
    2024-08-01
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInborn Errors of Metabolism
    InterventionSkin biopsy; Withdraw of blood
    PhaseNot recorded
    Registry statusUnknown

  • Population Pharmacokinetics of Anti-tuberculosis Drugs in Children With Tuberculosis

    NCT03625739 · start 2018-07-01

    Registered record
    Registry ID
    NCT03625739
    Conditions
    Tuberculosis
    Interventions
    anti-tuberculosis drug
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2018-07-01
    Completion
    2026-12-31
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    Interventionanti-tuberculosis drug
    PhaseNot recorded
    Registry statusRecruiting

  • The Individualized M(X) Drug-resistant TB Treatment Strategy Study

    NCT03237182 · start 2017-06-14

    Registered record
    Registry ID
    NCT03237182
    Conditions
    Tuberculosis, Multidrug-Resistant
    Interventions
    Individualized TB treatment with multiple drugs; Standardized TB treatment with multiple drugs
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-06-14
    Completion
    2022-12-19
    Enrolment
    205

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis, Multidrug-Resistant
    InterventionIndividualized TB treatment with multiple drugs; Standardized TB treatment with multiple drugs
    PhasePhase 4
    Registry statusTerminated

  • A Novel Surgical Method in the Treatment of Unstable Vitiligo

    NCT03013049 · start 2016-01

    Registered record
    Registry ID
    NCT03013049
    Conditions
    Vitiligo
    Interventions
    Non cultured epidermal cell suspension; Non cultured dermal cell suspension
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-01
    Completion
    2017-06
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitiligo
    InterventionNon cultured epidermal cell suspension; Non cultured dermal cell suspension
    PhaseNot applicable
    Registry statusUnknown

  • An Exploratory Study of TMC207 in Japanese Participants With Pulmonary Multi-Drug Resistant Tuberculosis (MDR-TB)

    NCT02365623 · start 2015-02-18

    Registered record
    Registry ID
    NCT02365623
    Conditions
    Tuberculosis, Multidrug-Resistant
    Interventions
    TMC207 (bedaquiline); Background Regimen (BR)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-02-18
    Completion
    2018-11-08
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis, Multidrug-Resistant
    InterventionTMC207 (bedaquiline); Background Regimen (BR)
    PhasePhase 2
    Registry statusCompleted

  • Effect Of Mesenchymal Stem Cells Transfusion on the Diabetic Peripheral Neuropathy Patients .

    NCT02387749 · start 2014-05

    Registered record
    Registry ID
    NCT02387749
    Conditions
    Diabetic Peripheral Neuropathy
    Interventions
    mesenchymal stem cells
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-05
    Completion
    2016-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Peripheral Neuropathy
    Interventionmesenchymal stem cells
    PhaseNot applicable
    Registry statusCompleted

  • FGF19 and the Expression of IRS-1 and GLUT-1 in Gestational Diabetes Mellitus

    NCT03816605 · start 2014-04

    Registered record
    Registry ID
    NCT03816605
    Conditions
    Gestational Diabetes Mellitus
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-04
    Completion
    2016-04
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGestational Diabetes Mellitus
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • AllogeneiC Human Mesenchymal Stem Cells (hMSC) in Patients With Aging FRAilTy Via IntravenoUS Delivery

    NCT02065245 · start 2014-03-03

    Registered record
    Registry ID
    NCT02065245
    Conditions
    Frailty
    Interventions
    Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs); Placebo; Penicillin/Streptomycin-Free Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2014-03-03
    Completion
    2020-10-02
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFrailty
    InterventionAllogeneic Human Mesenchymal Stem Cells (allo-hMSCs); Placebo; Penicillin/Streptomycin-Free Allogeneic Human Mesenchymal Stem Cells (allo-hMSCs)
    PhasePhase 1 / Phase 2
    Registry statusCompleted