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AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone

FDA-approved product (tablet, oral), marketed as Celestone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA53.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae30.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis25.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Topical Tapinarof Versus Betamethasone in the Treatment of Plaque Psoriasis

    NCT07635043 · start 2026-08-01

    Registered record
    Registry ID
    NCT07635043
    Conditions
    Psoriasis (PsO)
    Interventions
    Betamethasone Dipropionate 0.05% Cream; Tapinarof Cream 1%
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-08-01
    Completion
    2026-11-30
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis (PsO)
    InterventionBetamethasone Dipropionate 0.05% Cream; Tapinarof Cream 1%
    PhasePhase 4
    Registry statusNot yet recruiting

  • Clinical and Economic Evaluation of Point-of-care Ultrasound-guided Infiltration for Subacromial and Carpal Tunnel Syndromes in Primary Care: a Cluster-randomized Study Protocol.

    NCT07692516 · start 2026-06-01

    Registered record
    Registry ID
    NCT07692516
    Conditions
    Subacromial Impingement Syndrome; Carpal Tunnel Syndrome (CTS); Pain Management
    Interventions
    Standard Oral Treatment; Conventional Infiltration; Ultrasound-Guided Infiltration
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2026-06-01
    Completion
    2028-06-30
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubacromial Impingement Syndrome; Carpal Tunnel Syndrome (CTS); Pain Management
    InterventionStandard Oral Treatment; Conventional Infiltration; Ultrasound-Guided Infiltration
    PhasePhase 4
    Registry statusActive not recruiting

  • Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?

    NCT07447739 · start 2026-04

    Registered record
    Registry ID
    NCT07447739
    Conditions
    Respiratory Distress Syndrome (RDS); Bronchopulmonary Dysplasia (BPD)
    Interventions
    Betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-04
    Completion
    2029-03
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome (RDS); Bronchopulmonary Dysplasia (BPD)
    InterventionBetamethasone
    PhasePhase 2
    Registry statusNot yet recruiting

  • A Study to Evaluate the Efficacy,Safety,Tolerability,Pharmacokinetics,and Immunogenicty of Plonmarlimab in Subjects With Acute Gouty Arthritis

    NCT07453004 · start 2026-03-26

    Registered record
    Registry ID
    NCT07453004
    Conditions
    Acute Gouty Arthritis
    Interventions
    Plonmarlimab; Compound betamethasone; Plonmarlimab placebo; Compound betamethasone placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2026-03-26
    Completion
    2027-12-31
    Enrolment
    170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Gouty Arthritis
    InterventionPlonmarlimab; Compound betamethasone; Plonmarlimab placebo; Compound betamethasone placebo
    PhasePhase 2
    Registry statusRecruiting

  • Comparison of Efficacy of Betamethasone Gel With Lidocaine Gel in Prevention of Post Endotracheal Intubation Sore Throat.

    NCT07256834 · start 2025-11-22

    Registered record
    Registry ID
    NCT07256834
    Conditions
    Post Operative Sore Throat at 6hrs and 24hrs After Endotracheal Intubation
    Interventions
    Betamethasone dipropionate 0.05%; Lidocaine hydrochloride 2%
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Not yet recruiting
    Start
    2025-11-22
    Completion
    2025-12-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Operative Sore Throat at 6hrs and 24hrs After Endotracheal Intubation
    InterventionBetamethasone dipropionate 0.05%; Lidocaine hydrochloride 2%
    PhasePhase 1 / Phase 2
    Registry statusNot yet recruiting

  • Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography

    NCT06527235 · start 2025-03-06

    Registered record
    Registry ID
    NCT06527235
    Conditions
    Meniscus Lesion
    Interventions
    ultrasound-guided betamethasone infiltration of the meniscal wall; ultrasound-guided isotonic saline (placebo) infiltration of the meniscal wall
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2025-03-06
    Completion
    2028-06-01
    Enrolment
    152

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMeniscus Lesion
    Interventionultrasound-guided betamethasone infiltration of the meniscal wall; ultrasound-guided isotonic saline (placebo) infiltration of the meniscal wall
    PhasePhase 3
    Registry statusRecruiting

  • Suprascapular Nerve Block in the Management of Patients Diagnosed With Adhesive Capsulitis

    NCT07097571 · start 2025-02-26

    Registered record
    Registry ID
    NCT07097571
    Conditions
    Adhesive Capsulitis of the Shoulder; Suprascapular Nerve Block
    Interventions
    Glenohumeral Joint Injection and Suprascapular Nerve Block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2025-02-26
    Completion
    2026-08-26
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdhesive Capsulitis of the Shoulder; Suprascapular Nerve Block
    InterventionGlenohumeral Joint Injection and Suprascapular Nerve Block
    PhaseNot applicable
    Registry statusActive not recruiting

  • Analgesic Efficacy of Preemptive Stepwise Infiltration Anesthesia for Perioperative Analgesia After TKA

    NCT06600815 · start 2024-09-30

    Registered record
    Registry ID
    NCT06600815
    Conditions
    Total Knee Arthroplasty; Pain Management
    Interventions
    preemptive stepwise infiltration anaesthesia(PSIA); postoperative local infiltration analgesia(PLIA)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-09-30
    Completion
    2025-12
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTotal Knee Arthroplasty; Pain Management
    Interventionpreemptive stepwise infiltration anaesthesia(PSIA); postoperative local infiltration analgesia(PLIA)
    PhaseNot applicable
    Registry statusRecruiting

  • Effect of Corticosteroid Injection in Symptomatic Pulpitis Cases

    NCT07704398 · start 2023-10-23

    Registered record
    Registry ID
    NCT07704398
    Conditions
    Periapical Periodontitis
    Interventions
    Corticosteroid; Standard endodontic treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-10-23
    Completion
    2026-04-23
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriapical Periodontitis
    InterventionCorticosteroid; Standard endodontic treatment
    PhaseNot applicable
    Registry statusCompleted

  • The Effects of Two Different Treatment Protocols on Shoulder Function, Quality of Life, and Ultrasound Parameters in Patients With Frozen Shoulder

    NCT05956171 · start 2023-10-01

    Registered record
    Registry ID
    NCT05956171
    Conditions
    Frozen Shoulder; Shoulder Capsulitis; Shoulder Pain
    Interventions
    Intra-articular corticosteroid injection; Ultrasound Guided Hydrodilatation with corticosteroid injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-10-01
    Completion
    2024-03
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFrozen Shoulder; Shoulder Capsulitis; Shoulder Pain
    InterventionIntra-articular corticosteroid injection; Ultrasound Guided Hydrodilatation with corticosteroid injection
    PhaseNot applicable
    Registry statusUnknown

  • Efficacy and Safety of Timolol for TKI Induced Paronychia

    NCT06140186 · start 2023-04-01

    Registered record
    Registry ID
    NCT06140186
    Conditions
    Paronychia
    Interventions
    Topical Timolol; Betamethasone Valerate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2023-04-01
    Completion
    2024-03-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParonychia
    InterventionTopical Timolol; Betamethasone Valerate
    PhasePhase 3
    Registry statusUnknown

  • Efficacies of Different Managements in Patients With Trigger Finger

    NCT06382623 · start 2022-10-01

    Registered record
    Registry ID
    NCT06382623
    Conditions
    Trigger Finger
    Interventions
    The percutaneous A1 pulley release; The peritendinous Betamethasone group
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-10-01
    Completion
    2023-06-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTrigger Finger
    InterventionThe percutaneous A1 pulley release; The peritendinous Betamethasone group
    PhaseNot recorded
    Registry statusCompleted

  • Comparative Bioavailability of Betamethasone Oral Solution Metered Spray (GTX-102) in Healthy Subjects

    NCT05531890 · start 2022-09-13

    Registered record
    Registry ID
    NCT05531890
    Conditions
    Ataxia Telangiectasia
    Interventions
    GTX-102 medium dose fast Period 1 and Period 2; GTX-102 medium dose slow Period 1 and Period 2; GTX-102 high dose fast Period 1 and Period 2; GTX-102 low dose fast Period 1 and Period 2; Betamethasone solution as intramuscular injection Period 1 and Period 2; Betamethasone Oral Solution Period 1 and Period 2
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2022-09-13
    Completion
    2023-05-03
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtaxia Telangiectasia
    InterventionGTX-102 medium dose fast Period 1 and Period 2; GTX-102 medium dose slow Period 1 and Period 2; GTX-102 high dose fast Period 1 and Period 2; GTX-102 low dose fast Period 1 and Period 2 +2 more
    PhasePhase 1
    Registry statusUnknown

  • Topical Calcipotriol /Betamethasone Ointment in the Treatment of Plaque Psoriasis

    NCT06011083 · start 2022-08-01

    Registered record
    Registry ID
    NCT06011083
    Conditions
    Psoriasis Vulgaris; Fractional CO2 Laser
    Interventions
    Topical Ointment containing Calcipotriol 0.05 mg/gm and Betamethasone dipropionate 0.5 mg/gm; Fractional carbon dioxide (CO2) laser
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-08-01
    Completion
    2023-08-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis Vulgaris; Fractional CO2 Laser
    InterventionTopical Ointment containing Calcipotriol 0.05 mg/gm and Betamethasone dipropionate 0.5 mg/gm; Fractional carbon dioxide (CO2) laser
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Intercostal Nerve Block for Chronic Post-thoracotomy Pain

    NCT05556122 · start 2022-07-04

    Registered record
    Registry ID
    NCT05556122
    Conditions
    Nerve Block
    Interventions
    intercostal nerve block; lateral intercostal nerve block; ropivacaine + compound betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-07-04
    Completion
    2022-12-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNerve Block
    Interventionintercostal nerve block; lateral intercostal nerve block; ropivacaine + compound betamethasone
    PhaseNot applicable
    Registry statusUnknown