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AMR Drug RepurposingSmart Screeningresearch prototype

Mifepristone

FDA-approved product (tablet, oral), marketed as Korlym, Mifeprex, Mifepristone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Mifepristone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cushing syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Progesterone receptor modulators
FDA pharmacologic class
Progestin Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae39.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mifepristone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

-4.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mifepristone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Mifepristone in Males With Type 2 Diabetes Mellitus

    NCT03052400 · start 2017-02-03

    Registered record
    Registry ID
    NCT03052400
    Conditions
    Type 2 Diabetes Mellitus; Insulin Resistance
    Interventions
    Mifepristone 600 mg daily; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2017-02-03
    Completion
    2021-05-31
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 2 Diabetes Mellitus; Insulin Resistance
    InterventionMifepristone 600 mg daily; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion

    NCT03044093 · start 2017-01

    Registered record
    Registry ID
    NCT03044093
    Conditions
    Second Trimester Abortion
    Interventions
    Mifepristone; Placebo; Misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-01
    Completion
    2019-01
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSecond Trimester Abortion
    InterventionMifepristone; Placebo; Misoprostol
    PhasePhase 4
    Registry statusUnknown

  • 24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E

    NCT03134183 · start 2016-11-19

    Registered record
    Registry ID
    NCT03134183
    Conditions
    Abortion, Second Trimester
    Interventions
    Vaginal Misoprostol; Buccal Misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-11-19
    Completion
    2017-08-01
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, Second Trimester
    InterventionVaginal Misoprostol; Buccal Misoprostol
    PhasePhase 4
    Registry statusCompleted

  • Mifepristone Induction for Fetal Demise

    NCT02620904 · start 2016-07-14

    Registered record
    Registry ID
    NCT02620904
    Conditions
    Intrauterine Fetal Demise; Fetal Death
    Interventions
    Mifepristone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2016-07-14
    Completion
    2020-01
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntrauterine Fetal Demise; Fetal Death
    InterventionMifepristone; placebo
    PhasePhase 4
    Registry statusTerminated

  • Efficacy of Mifepristone - Prostaglandin Analogue Combination in Medical Termination of Pregnancy Beyond 7 Weeks of Amenorrhea

    NCT02614781 · start 2015-11

    Registered record
    Registry ID
    NCT02614781
    Conditions
    Medical Termination of Pregnancy
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-11
    Completion
    2016-05
    Enrolment
    892

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMedical Termination of Pregnancy
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Self-Assessment of Medical Abortion Outcome Using Serial Multi-level Pregnancy Tests

    NCT02570204 · start 2015-09

    Registered record
    Registry ID
    NCT02570204
    Conditions
    Medical Abortion
    Interventions
    Self-assessment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-09
    Completion
    2016-12
    Enrolment
    343

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMedical Abortion
    InterventionSelf-assessment
    PhaseNot applicable
    Registry statusCompleted

  • Outpatient Medical Abortion With Mifepristone and Misoprostol Through 77 Days of Gestation

    NCT02314754 · start 2014-12

    Registered record
    Registry ID
    NCT02314754
    Conditions
    Medical Abortion
    Interventions
    Mifepristone followed by misoprostol 24-48 hours later
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-12
    Completion
    2016-04
    Enrolment
    719

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMedical Abortion
    InterventionMifepristone followed by misoprostol 24-48 hours later
    PhasePhase 4
    Registry statusCompleted

  • CORT125134 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)

    NCT03508635 · start 2014-09

    Registered record
    Registry ID
    NCT03508635
    Conditions
    Healthy
    Interventions
    CORT125134; Matching Placebo of CORT125134; Mifepristone; Prednisone; Glucose
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-09
    Completion
    2015-12
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCORT125134; Matching Placebo of CORT125134; Mifepristone; Prednisone +1 more
    PhasePhase 1
    Registry statusCompleted

  • A Pilot of an Outpatient Regimen of Medical Abortion With Mifepristone and Sublingual Misoprostol in the 11 and 12 Weeks

    NCT02720991 · start 2014-07

    Registered record
    Registry ID
    NCT02720991
    Conditions
    Abortion, 3 Months
    Interventions
    Mifepristone; Sublingual misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-07
    Completion
    2015-04
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, 3 Months
    InterventionMifepristone; Sublingual misoprostol
    PhasePhase 4
    Registry statusCompleted

  • Effects of Mifepristone on Biomarkers of Metabolic Function and Neuropsychological Performance Among Middle-Aged and Older Individuals

    NCT01988610 · start 2013-10

    Registered record
    Registry ID
    NCT01988610
    Conditions
    Depression
    Interventions
    28 days treatment with Mifepristone.
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-10
    Completion
    2017-02
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    Intervention28 days treatment with Mifepristone.
    PhasePhase 1
    Registry statusCompleted

  • Cervical Preparation Before Dilation and Evacuation

    NCT01751087 · start 2013-01

    Registered record
    Registry ID
    NCT01751087
    Conditions
    Abortion, Induced
    Interventions
    Mifepristone; misoprostol; Osmotic dilators; placebo; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-01
    Completion
    2014-06
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, Induced
    InterventionMifepristone; misoprostol; Osmotic dilators; placebo +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Mifepristone and Misoprostol for Mid-trimester Termination of Pregnancy in Armenia

    NCT01766388 · start 2012-12

    Registered record
    Registry ID
    NCT01766388
    Conditions
    Abortion in Second Trimester
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-12
    Completion
    2013-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion in Second Trimester
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone

    NCT01739335 · start 2012-11-19

    Registered record
    Registry ID
    NCT01739335
    Conditions
    Stress Disorders, Post-Traumatic
    Interventions
    Mifepristone Oral Tablet [Korlym]; Placebo Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-11-19
    Completion
    2016-11-16
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStress Disorders, Post-Traumatic
    InterventionMifepristone Oral Tablet [Korlym]; Placebo Oral Tablet
    PhasePhase 2
    Registry statusCompleted

  • Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks

    NCT01636063 · start 2012-06

    Registered record
    Registry ID
    NCT01636063
    Conditions
    Induced Abortion; Abortion Techniques; Mifepristone; Misoprostol
    Interventions
    Mifepristone; Misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2012-06
    Completion
    2014-05
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInduced Abortion; Abortion Techniques; Mifepristone; Misoprostol
    InterventionMifepristone; Misoprostol
    PhaseNot applicable
    Registry statusTerminated

  • Acceptability and Feasibility of a Demedicalized Medical Abortion Regimen in the Caucasus

    NCT02219100 · start 2010-11

    Registered record
    Registry ID
    NCT02219100
    Conditions
    Abortion, First Trimester
    Interventions
    Home administration of 200 mg mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-11
    Completion
    2011-11
    Enrolment
    613

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, First Trimester
    InterventionHome administration of 200 mg mifepristone
    PhaseNot applicable
    Registry statusCompleted