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AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone Sodium Phosphate

FDA-approved product (injectable, injection), marketed as Betamethasone Sodium Phosphate, Celestone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone Sodium Phosphate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Ulcerative colitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone Sodium Phosphate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone Sodium Phosphate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intra Articular Injection of Ozone With Corticosteroids vs PRGF in Knee Osteoarthritis

    NCT05837494 · start 2022-06-01

    Registered record
    Registry ID
    NCT05837494
    Conditions
    Intra Articular Injection; Corticosteroids; Plasma Rich in Growth Factors; Knee Osteoarthritis
    Interventions
    Intra-articular Ozone and corticosteroids; intra-articular PRGF Method
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-06-01
    Completion
    2023-05-20
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntra Articular Injection; Corticosteroids; Plasma Rich in Growth Factors; Knee Osteoarthritis
    InterventionIntra-articular Ozone and corticosteroids; intra-articular PRGF Method
    PhaseNot applicable
    Registry statusCompleted

  • Radiofrequency Ablation in the Pain Management of Knee Osteoarthritis

    NCT05303766 · start 2022-04

    Registered record
    Registry ID
    NCT05303766
    Conditions
    Knee Osteoarthritis
    Interventions
    Radio-frequency ablation; Intra-articular steroids; Pulsed Radio-frequency
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-04
    Completion
    2023-03
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKnee Osteoarthritis
    InterventionRadio-frequency ablation; Intra-articular steroids; Pulsed Radio-frequency
    PhaseNot applicable
    Registry statusUnknown

  • Betamethasone and Complications of Lower Third Molar Surgery

    NCT07297264 · start 2022-01-03

    Registered record
    Registry ID
    NCT07297264
    Conditions
    Morbidity; Third Molars Extraction; Steroid Injection
    Interventions
    Betamethasone; normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2022-01-03
    Completion
    2023-03-26
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbidity; Third Molars Extraction; Steroid Injection
    InterventionBetamethasone; normal saline
    PhasePhase 3
    Registry statusTerminated

  • Low Dose Antenatal Corticosteroids for Late Preterm Delivery

    NCT05698966 · start 2022-01-01

    Registered record
    Registry ID
    NCT05698966
    Conditions
    Respiratory Morbidity; Preterm Labor
    Interventions
    we will use reduced dose of acceptable corticosteroids treatment for preterm birth
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2022-01-01
    Completion
    2028-01-01
    Enrolment
    1,510

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Morbidity; Preterm Labor
    Interventionwe will use reduced dose of acceptable corticosteroids treatment for preterm birth
    PhaseNot applicable
    Registry statusRecruiting

  • Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye Disease

    NCT04976816 · start 2021-12-01

    Registered record
    Registry ID
    NCT04976816
    Conditions
    Thyroid Eye Disease
    Interventions
    peri-levator betamethasone injection; peri-levator triamcinolone injection; peri-levator and retrobulbar betamethasone injection; peri-levator and retrobulbar triamcinolone injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2021-12-01
    Completion
    2023-10-30
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Eye Disease
    Interventionperi-levator betamethasone injection; peri-levator triamcinolone injection; peri-levator and retrobulbar betamethasone injection; peri-levator and retrobulbar triamcinolone injection
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Amnion-Based Injections in the Shoulder

    NCT03770546 · start 2021-10-30

    Registered record
    Registry ID
    NCT03770546
    Conditions
    Osteoarthritis of the Shoulder; Adhesive Capsulitis
    Interventions
    Amnion Injection; Betamethasone injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2021-10-30
    Completion
    2023-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis of the Shoulder; Adhesive Capsulitis
    InterventionAmnion Injection; Betamethasone injection
    PhaseNot applicable
    Registry statusWithdrawn

  • Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy

    NCT04153396 · start 2021-09-01

    Registered record
    Registry ID
    NCT04153396
    Conditions
    Pain, Postoperative; Neurosurgery
    Interventions
    The Treatment group; The Control group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-09-01
    Completion
    2022-06-03
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative; Neurosurgery
    InterventionThe Treatment group; The Control group
    PhasePhase 4
    Registry statusCompleted

  • Late Preterm Corticosteroids and Neonatal Hypoglycemia

    NCT04869709 · start 2021-07

    Registered record
    Registry ID
    NCT04869709
    Conditions
    Neonatal Hypoglycemia; Prematurity
    Interventions
    Betamethasone Sodium Phosphate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2021-07
    Completion
    2024-07
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeonatal Hypoglycemia; Prematurity
    InterventionBetamethasone Sodium Phosphate
    PhasePhase 4
    Registry statusUnknown

  • Comparative Study Between Steroid Plus Anesthetic Block and CRF in Participants With Hip Osteoarthritis

    NCT04876859 · start 2021-06-08

    Registered record
    Registry ID
    NCT04876859
    Conditions
    Hip Osteoarthritis; Chronic Pain
    Interventions
    CRF of anterior sensitive branches to the hip; Anesthetic block with steroid injection of anterior sensitive branches to the hip
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Suspended
    Start
    2021-06-08
    Completion
    2024-11-30
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Osteoarthritis; Chronic Pain
    InterventionCRF of anterior sensitive branches to the hip; Anesthetic block with steroid injection of anterior sensitive branches to the hip
    PhasePhase 3
    Registry statusSuspended

  • Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth

    NCT04494529 · start 2021-03-01

    Registered record
    Registry ID
    NCT04494529
    Conditions
    Preterm Birth; Complication of Prematurity; Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications
    Interventions
    12 mg betamethasone + placebo; 24 mg betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-03-01
    Completion
    2021-08-31
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Birth; Complication of Prematurity; Obstetric Labor, Premature; Obstetric Labor Complications +1 more
    Intervention12 mg betamethasone + placebo; 24 mg betamethasone
    PhasePhase 3
    Registry statusCompleted

  • A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease

    NCT04734197 · start 2021-01-11

    Registered record
    Registry ID
    NCT04734197
    Conditions
    Dry Eye Disease
    Interventions
    SURF-100 (Combination of 0.3% Mycophenolic Acid and 0.01% Betamethasone Sodium Phosphate); Mycophenolic Acid 0.1%; Mycophenolic Acid 0.3%; Betamethasone Sodium Phosphate 0.01%; Placebo Comparator: Vehicle; Cyclosporine 0.05% Ophthalmic Emulsion; Lifitegrast 5% Ophthalmic Solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-01-11
    Completion
    2022-03-25
    Enrolment
    349

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDry Eye Disease
    InterventionSURF-100 (Combination of 0.3% Mycophenolic Acid and 0.01% Betamethasone Sodium Phosphate); Mycophenolic Acid 0.1%; Mycophenolic Acid 0.3%; Betamethasone Sodium Phosphate 0.01% +3 more
    PhasePhase 2
    Registry statusCompleted

  • Research Study To See How Well An Eye Drop (SURF-200) Works, What Side Effects There Are, And To Compare It With Vehicle In Subjects With An Episodic Flare-Up of Dry Eye Disease

    NCT04734210 · start 2021-01-07

    Registered record
    Registry ID
    NCT04734210
    Conditions
    Dry Eye Disease
    Interventions
    0.02% Betamethasone Sodium Phosphate; 0.04% Betamethasone Sodium Phosphate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-01-07
    Completion
    2022-10-12
    Enrolment
    139

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDry Eye Disease
    Intervention0.02% Betamethasone Sodium Phosphate; 0.04% Betamethasone Sodium Phosphate; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Effect of ZILRETTA Versus CELESTONE on Quality of Life, Pain, Neuromuscular Function, and Physical Performance

    NCT05058209 · start 2020-11-30

    Registered record
    Registry ID
    NCT05058209
    Conditions
    Osteoarthritis, Knee
    Interventions
    Triamcinolone acetonide extended-release injectable suspension; Betamethasone sodium phosphate and betamethasone acetate Injectable Suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-11-30
    Completion
    2021-04-28
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee
    InterventionTriamcinolone acetonide extended-release injectable suspension; Betamethasone sodium phosphate and betamethasone acetate Injectable Suspension
    PhasePhase 4
    Registry statusCompleted

  • Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)

    NCT04593706 · start 2020-11-01

    Registered record
    Registry ID
    NCT04593706
    Conditions
    Keloid; Hypertrophic Scar; Scars; Scarring
    Interventions
    Betamethasone acetate + Betamethasone sodium phosphate; Dexamethasone sodium phosphate; Methylprednisolone acetate; Triamcinolone acetonide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-11-01
    Completion
    2021-10-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeloid; Hypertrophic Scar; Scars; Scarring
    InterventionBetamethasone acetate + Betamethasone sodium phosphate; Dexamethasone sodium phosphate; Methylprednisolone acetate; Triamcinolone acetonide
    PhaseNot applicable
    Registry statusUnknown

  • Chronic Non Bacterial Prostatitis: a Trial of TRUS Guided Injection of Betamethason

    NCT04210739 · start 2020-07

    Registered record
    Registry ID
    NCT04210739
    Conditions
    Chronic Non Bacterial Prostatitis
    Interventions
    Betamethason Sodium Phosphate
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2020-07
    Completion
    2021-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Non Bacterial Prostatitis
    InterventionBetamethason Sodium Phosphate
    PhaseEarly phase 1
    Registry statusUnknown