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AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone Sodium Phosphate

FDA-approved product (injectable, injection), marketed as Betamethasone Sodium Phosphate, Celestone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone Sodium Phosphate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Ulcerative colitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone Sodium Phosphate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone Sodium Phosphate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Betamethasone (Betapred®) as Premedication for Reducing Postoperative Vomiting and Pain After Tonsillectomy

    NCT03783182 · start 2019-09-10

    Registered record
    Registry ID
    NCT03783182
    Conditions
    Tonsillectomy; Pain; PONV; Bleeding
    Interventions
    Betamethason Sodium Phosphate; 10% glucose solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-09-10
    Completion
    2025-12-15
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTonsillectomy; Pain; PONV; Bleeding
    InterventionBetamethason Sodium Phosphate; 10% glucose solution
    PhasePhase 4
    Registry statusUnknown

  • Local Steroid Treatment for Idiopathic Granulomatous Mastitis (LSTIGM)

    NCT03766997 · start 2019-02-19

    Registered record
    Registry ID
    NCT03766997
    Conditions
    Granulomatous Mastitis
    Interventions
    Compound Betamethasone Injection; Hydrocortisone Butyrate 0.1% Cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-02-19
    Completion
    2022-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGranulomatous Mastitis
    InterventionCompound Betamethasone Injection; Hydrocortisone Butyrate 0.1% Cream
    PhasePhase 4
    Registry statusUnknown

  • Stress and Fetal Brain Development

    NCT03831126 · start 2019-02-01

    Registered record
    Registry ID
    NCT03831126
    Conditions
    Pregnancy
    Interventions
    Betamethason Sodium Phosphate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2019-02-01
    Completion
    2024-12-31
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy
    InterventionBetamethason Sodium Phosphate
    PhaseNot recorded
    Registry statusUnknown

  • Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells

    NCT03279796 · start 2018-10-01

    Registered record
    Registry ID
    NCT03279796
    Conditions
    Rotator Cuff Tear; Lateral Epicondylitis
    Interventions
    Autologous adipose-derived MSCs; Compound betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2018-10-01
    Completion
    2021-12-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tear; Lateral Epicondylitis
    InterventionAutologous adipose-derived MSCs; Compound betamethasone
    PhasePhase 2
    Registry statusUnknown

  • Injection Technique in Subacromial Impingement Syndrome

    NCT05266391 · start 2018-06-01

    Registered record
    Registry ID
    NCT05266391
    Conditions
    Subacromial Impingement Syndrome
    Interventions
    subacromial corticosteroid injections
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-06-01
    Completion
    2018-09-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubacromial Impingement Syndrome
    Interventionsubacromial corticosteroid injections
    PhaseNot recorded
    Registry statusCompleted

  • Effects of ACS in Twin With LPB: Study Protocol for a RCT

    NCT03547791 · start 2018-05-05

    Registered record
    Registry ID
    NCT03547791
    Conditions
    Twin Pregnancy, Antepartum Condition or Complication
    Interventions
    Betamethason Sodium Phosphate; Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2018-05-05
    Completion
    2024-07-26
    Enrolment
    848

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTwin Pregnancy, Antepartum Condition or Complication
    InterventionBetamethason Sodium Phosphate; Normal saline
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Impact of Autologous Pure Platelet-rich Plasma in the Treatment of Tendon Disease

    NCT03300531 · start 2017-12-01

    Registered record
    Registry ID
    NCT03300531
    Conditions
    Rotator Cuff Tear; Lateral Epicondylitis; Achilles Tendinitis
    Interventions
    Ultrasound-guided pure platelet-rich-plasma (P-PRP) injection; Ultrasound-guided platelet-rich-plasma (PRP) injection; Ultrasound-guided Compound betamethasone injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2017-12-01
    Completion
    2021-12-31
    Enrolment
    540

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tear; Lateral Epicondylitis; Achilles Tendinitis
    InterventionUltrasound-guided pure platelet-rich-plasma (P-PRP) injection; Ultrasound-guided platelet-rich-plasma (PRP) injection; Ultrasound-guided Compound betamethasone injection
    PhasePhase 2
    Registry statusUnknown

  • Effect of Antenatal Corticosteroids on Neonatal Morbidity.

    NCT03446937 · start 2017-12-01

    Registered record
    Registry ID
    NCT03446937
    Conditions
    Neonatal Respiratory Distress Syndrome
    Interventions
    Dexamethasone Sodium Phosphate Injection; Betamethasone Sodium Phosphate Injection (Medication); Water for injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-12-01
    Completion
    2019-05-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeonatal Respiratory Distress Syndrome
    InterventionDexamethasone Sodium Phosphate Injection; Betamethasone Sodium Phosphate Injection (Medication); Water for injection
    PhaseNot applicable
    Registry statusCompleted

  • Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study

    NCT03707795 · start 2017-08-21

    Registered record
    Registry ID
    NCT03707795
    Conditions
    Familial Amyotrophic Lateral Sclerosis
    Interventions
    Betamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2017-08-21
    Completion
    2019-01-10
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFamilial Amyotrophic Lateral Sclerosis
    InterventionBetamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
    PhaseEarly phase 1
    Registry statusCompleted

  • A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain

    NCT03240783 · start 2017-07-08

    Registered record
    Registry ID
    NCT03240783
    Conditions
    Acute Sciatica
    Interventions
    Betamethasone OR Dexamethasone Injectable; Normal Saline Flush, 0.9% Injectable Solution; Dexamethasone Oral Tablet; Sham Injection and/or oral placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2017-07-08
    Completion
    2018-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Sciatica
    InterventionBetamethasone OR Dexamethasone Injectable; Normal Saline Flush, 0.9% Injectable Solution; Dexamethasone Oral Tablet; Sham Injection and/or oral placebo
    PhasePhase 2
    Registry statusUnknown

  • Injection of Corticoids for the Treatment of Acute Sprains of the Proximal Interphalangeal Joints of the Fingers.

    NCT02916940 · start 2016-11-16

    Registered record
    Registry ID
    NCT02916940
    Conditions
    Sprain
    Interventions
    Diprophos
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-11-16
    Completion
    2020-02-11
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSprain
    InterventionDiprophos
    PhasePhase 2
    Registry statusCompleted

  • "Corticoid-16" in Long Term When Administered Systemically in Patients in Routine Medical Practice

    NCT03119454 · start 2016-10

    Registered record
    Registry ID
    NCT03119454
    Conditions
    Pharmacological Action
    Interventions
    Diprospan
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-10
    Completion
    2016-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacological Action
    InterventionDiprospan
    PhaseNot recorded
    Registry statusCompleted

  • Investigation of Corticosteroid Versus Placebo Injection in Patients With Syndesmotic Ligament Injury or High Ankle Sprain

    NCT02892500 · start 2016-04

    Registered record
    Registry ID
    NCT02892500
    Conditions
    Ankle Injuries
    Interventions
    bupivacaine hydrochloride and betamethasone sodium phosphate; bupivacaine hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2016-04
    Completion
    2016-09-21
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnkle Injuries
    Interventionbupivacaine hydrochloride and betamethasone sodium phosphate; bupivacaine hydrochloride
    PhasePhase 2
    Registry statusTerminated

  • Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy

    NCT02652884 · start 2016-01

    Registered record
    Registry ID
    NCT02652884
    Conditions
    Transient Hypoparathyroidism
    Interventions
    phosphate and betamethasone acetate, 2 mL.; saline 0.9% NaCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-01
    Completion
    2017-12
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTransient Hypoparathyroidism
    Interventionphosphate and betamethasone acetate, 2 mL.; saline 0.9% NaCl
    PhasePhase 4
    Registry statusUnknown

  • Intra-articular Betamethasone and the Hypothalamic-pituitary-adrenal Axis

    NCT01799408 · start 2012-10

    Registered record
    Registry ID
    NCT01799408
    Conditions
    Adrenal Suppression
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-10
    Completion
    2013-02
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdrenal Suppression
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted