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AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone Sodium Phosphate

FDA-approved product (injectable, injection), marketed as Betamethasone Sodium Phosphate, Celestone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone Sodium Phosphate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Ulcerative colitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone Sodium Phosphate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone Sodium Phosphate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery

    NCT07626463 · start 2026-05-30

    Registered record
    Registry ID
    NCT07626463
    Conditions
    Laparoscopic Surgery; Laparoscopic Appendectomy; Laparoscopic Cholecystectomy; Laparoscopic Hernia Repair Surgery; Infiltration Anesthesia
    Interventions
    Pre-incisional infiltration with ropivacaine and diprospan; Pre-incisional infiltration with ropivacaine alone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-05-30
    Completion
    2028-05-30
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic Surgery; Laparoscopic Appendectomy; Laparoscopic Cholecystectomy; Laparoscopic Hernia Repair Surgery +1 more
    InterventionPre-incisional infiltration with ropivacaine and diprospan; Pre-incisional infiltration with ropivacaine alone
    PhaseNot applicable
    Registry statusRecruiting

  • PRP vs PRP+Betamethasone vs Betamethasone Injection for Upper Trapezius Myofascial Pain

    NCT07547605 · start 2026-05-15

    Registered record
    Registry ID
    NCT07547605
    Conditions
    Myofascial Pain Dysfunction Syndrome; Trigger Points, Myofascial; Trigger Point in Trapezius Muscle
    Interventions
    Autologous Platelet-Rich Plasma (PRP); PRP plus Betamethasone; Betamethasone (Diprospan)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-05-15
    Completion
    2027-01
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyofascial Pain Dysfunction Syndrome; Trigger Points, Myofascial; Trigger Point in Trapezius Muscle
    InterventionAutologous Platelet-Rich Plasma (PRP); PRP plus Betamethasone; Betamethasone (Diprospan)
    PhasePhase 4
    Registry statusRecruiting

  • Efficacy of Corticosteroid Injection and Nerve Hydrodissection in Carpal Tunnel Syndrome

    NCT06882603 · start 2025-10-14

    Registered record
    Registry ID
    NCT06882603
    Conditions
    Carpal Tunnel Syndrome (CTS)
    Interventions
    hydrodissection; Steroid injection; Exercise
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-10-14
    Completion
    2026-05-05
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarpal Tunnel Syndrome (CTS)
    Interventionhydrodissection; Steroid injection; Exercise
    PhaseNot applicable
    Registry statusRecruiting

  • Ropiclobet for Regional Anesthesia and Post-Operative Pain Control in Upper Extremity Surgery

    NCT07131657 · start 2025-09-02

    Registered record
    Registry ID
    NCT07131657
    Conditions
    Nerve Block; Upper Extremity Surgery
    Interventions
    Ropivacaine + Clonidine + Betamethasone; Ropivacaine + Clonidine + Betamethasone; Ropivacaine + Clonidine + Betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2025-09-02
    Completion
    2025-12-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNerve Block; Upper Extremity Surgery
    InterventionRopivacaine + Clonidine + Betamethasone; Ropivacaine + Clonidine + Betamethasone; Ropivacaine + Clonidine + Betamethasone
    PhasePhase 2
    Registry statusCompleted

  • Effect of Pre-delivery Dexamethasone in Comparison With Betamethasone on Fetal Heart Trace

    NCT07078786 · start 2025-07-13

    Registered record
    Registry ID
    NCT07078786
    Conditions
    Cardiotocography; Steroids
    Interventions
    Betamethason Sodium Phosphate; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-07-13
    Completion
    2025-10-15
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiotocography; Steroids
    InterventionBetamethason Sodium Phosphate; Dexamethasone
    PhasePhase 4
    Registry statusRecruiting

  • Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus

    NCT06498180 · start 2024-12-31

    Registered record
    Registry ID
    NCT06498180
    Conditions
    Oral Lichen Planus; Periodontal Diseases
    Interventions
    Periodontal initial treatment under local anesthesia; Glucocorticoid Therapy; oral hygiene instruction
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2024-12-31
    Completion
    2028-03-31
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus; Periodontal Diseases
    InterventionPeriodontal initial treatment under local anesthesia; Glucocorticoid Therapy; oral hygiene instruction
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Phase I Study of Ropivacaine, Clonidine, and Betamethasone Combination for Sciatic Nerve Block in the Popliteal Region

    NCT06781632 · start 2024-11-13

    Registered record
    Registry ID
    NCT06781632
    Conditions
    Healthy; Nerve Block
    Interventions
    ropivacaine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2024-11-13
    Completion
    2025-04-25
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Nerve Block
    Interventionropivacaine
    PhasePhase 1
    Registry statusCompleted

  • Analgesic Efficacy of Preemptive Stepwise Infiltration Anesthesia for Perioperative Analgesia After TKA

    NCT06600815 · start 2024-09-30

    Registered record
    Registry ID
    NCT06600815
    Conditions
    Total Knee Arthroplasty; Pain Management
    Interventions
    preemptive stepwise infiltration anaesthesia(PSIA); postoperative local infiltration analgesia(PLIA)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-09-30
    Completion
    2025-12
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTotal Knee Arthroplasty; Pain Management
    Interventionpreemptive stepwise infiltration anaesthesia(PSIA); postoperative local infiltration analgesia(PLIA)
    PhaseNot applicable
    Registry statusRecruiting

  • Effectiveness of a Single Dose of Betamethasone in Children With Symptomatic Adenovirus Infection

    NCT06299813 · start 2024-03-20

    Registered record
    Registry ID
    NCT06299813
    Conditions
    Adenovirus
    Interventions
    Bentelan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2024-03-20
    Completion
    2026-04-01
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus
    InterventionBentelan; Placebo
    PhasePhase 3
    Registry statusUnknown

  • The Effects of Two Different Treatment Protocols on Shoulder Function, Quality of Life, and Ultrasound Parameters in Patients With Frozen Shoulder

    NCT05956171 · start 2023-10-01

    Registered record
    Registry ID
    NCT05956171
    Conditions
    Frozen Shoulder; Shoulder Capsulitis; Shoulder Pain
    Interventions
    Intra-articular corticosteroid injection; Ultrasound Guided Hydrodilatation with corticosteroid injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-10-01
    Completion
    2024-03
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFrozen Shoulder; Shoulder Capsulitis; Shoulder Pain
    InterventionIntra-articular corticosteroid injection; Ultrasound Guided Hydrodilatation with corticosteroid injection
    PhaseNot applicable
    Registry statusUnknown

  • Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)

    NCT05114096 · start 2023-07-20

    Registered record
    Registry ID
    NCT05114096
    Conditions
    Preterm Birth; Premature Birth; Complication of Prematurity; Obstetric Labor, Premature; Pregnancy Complications
    Interventions
    Celestone + placebo; Celestone + Celestone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2023-07-20
    Completion
    2029-12-31
    Enrolment
    3,254

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Birth; Premature Birth; Complication of Prematurity; Obstetric Labor, Premature +1 more
    InterventionCelestone + placebo; Celestone + Celestone
    PhasePhase 4
    Registry statusRecruiting

  • Corticosteroids in Carpal Tunnel Syndrome. Prospective Randomised Controlled Non-inferiority Study

    NCT06272682 · start 2023-07-17

    Registered record
    Registry ID
    NCT06272682
    Conditions
    Carpal Tunnel Syndrome
    Interventions
    Systemic bethametasone injection; Local bethametasone injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-07-17
    Completion
    2025-10-11
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarpal Tunnel Syndrome
    InterventionSystemic bethametasone injection; Local bethametasone injection
    PhaseNot applicable
    Registry statusUnknown

  • Investigation of the Effect of Central Sensitization (CS) on Steroid Injection Response in Rotator Cuff Lesion

    NCT05926895 · start 2023-06-02

    Registered record
    Registry ID
    NCT05926895
    Conditions
    Central Sensitisation; Subacromial Impingement Syndrome
    Interventions
    Injection of 1 CC Betamethasone Dipropionate + Betamethasone Sodium Phosphate (Diprospan) and 4 cc 2% Prilocaine (Priloc)mixture into the subacromial space
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-02
    Completion
    2024-12-30
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Sensitisation; Subacromial Impingement Syndrome
    InterventionInjection of 1 CC Betamethasone Dipropionate + Betamethasone Sodium Phosphate (Diprospan) and 4 cc 2% Prilocaine (Priloc)mixture into the subacromial space
    PhaseNot applicable
    Registry statusCompleted

  • Safety & Efffficacy of Genakumab in Patients With Frequent Flares

    NCT05983445 · start 2023-01-11

    Registered record
    Registry ID
    NCT05983445
    Conditions
    Acute Gout Arthritis
    Interventions
    genakumab; placebo for Diprospan; placebo for genakumab; Diprospan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2023-01-11
    Completion
    2024-04-03
    Enrolment
    313

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Gout Arthritis
    Interventiongenakumab; placebo for Diprospan; placebo for genakumab; Diprospan
    PhasePhase 3
    Registry statusCompleted

  • Opioid-free Total Hip Arthroplasty

    NCT04421196 · start 2022-09-15

    Registered record
    Registry ID
    NCT04421196
    Conditions
    Hip Osteoarthritis
    Interventions
    Exclusion of opioid analgesics
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2022-09-15
    Completion
    2023-12-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Osteoarthritis
    InterventionExclusion of opioid analgesics
    PhaseNot applicable
    Registry statusWithdrawn