Asenapine
FDA-approved product (system, transdermal), marketed as Secuado, Asenapine Maleate, Saphris.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Bipolar disorder
- Bipolar I disorder
- Psychosis
- Schizophrenia
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Diazepines, oxazepines, thiazepines and oxepines
- FDA pharmacologic class
- Atypical Antipsychotic FDA label ↗
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA36.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli32.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae12.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis61.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Asenapine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Trimetrexate GlucuronateExisting use: Other agents against amoebiasis and other protozoal diseases88.6% AI-predicted activityagainst E. coliLab records exist17 registered studies
- Folic AcidExisting use: Acne, Anemia, Anemia (phenotype) and 8 more87.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- MethotrexateExisting use: Acute lymphoblastic leukemia, Adenoma, Arthritis and 21 more86.8% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- PralatrexateExisting use: Cancer, Mature T-cell and NK-cell non-Hodgkin lymphoma, Neoplasm and 2 more82.2% AI-predicted activityagainst E. coli44 registered studies
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives81.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Leucovorin CalciumExisting use: Osteosarcoma67.6% AI-predicted activityagainst E. coli50+ registered studies
- LevoleucovorinExisting use: Anemia, Colorectal adenocarcinoma, Colorectal cancer and 3 more67.6% AI-predicted activityagainst E. coli50+ registered studies
- PyrimethamineExisting use: Malaria, Toxoplasmosis64.6% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Copanlisib DihydrochlorideExisting use: Follicular lymphoma, Neoplasm, Neoplasm of mature B-cells63.5% AI-predicted activityagainst E. coli10 registered studies
- AfamelanotideExisting use: Erythropoietic protoporphyria62.6% AI-predicted activityagainst E. coli23 registered studies
- Rimegepant SulfateExisting use: Migraine disorder61.6% AI-predicted activityagainst E. coli50+ registered studies
- Histrelin AcetateExisting use: Neoplasm, Prostate adenocarcinoma, Prostate cancer61.6% AI-predicted activityagainst E. coli13 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
6-week Trial of the Efficacy and Safety of Asenapine Compared to Placebo in Participants With an Acute Exacerbation of Schizophrenia (P06124)
NCT01098110 · start 2010-05-25
Registered record
- Registry ID
- NCT01098110
- Conditions
- Schizophrenia
- Interventions
- Asenapine 5 mg; Asenapine 10 mg; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2010-05-25
- Completion
- 2014-04-14
- Enrolment
- 532
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionAsenapine 5 mg; Asenapine 10 mg; PlaceboPhasePhase 3Registry statusCompletedLong-term Extension Trial of Asenapine in Subjects With Schizophrenia (Study P06125)
NCT01142596 · start 2010-05-25
Registered record
- Registry ID
- NCT01142596
- Conditions
- Schizophrenia
- Interventions
- Asenapine; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2010-05-25
- Completion
- 2015-04-22
- Enrolment
- 201
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionAsenapine; PlaceboPhasePhase 3Registry statusCompletedReducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics
NCT00806234 · start 2009-01
Registered record
- Registry ID
- NCT00806234
- Conditions
- Psychotic Disorders
- Interventions
- Aripiprazole or Perphenazine; Metformin; Olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone, paliperidone, or olanzapine/fluoxetine
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2009-01
- Completion
- 2014-03
- Enrolment
- 127
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPsychotic DisordersInterventionAripiprazole or Perphenazine; Metformin; Olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone, paliperidone, or olanzapine/fluoxetinePhasePhase 4Registry statusCompleted6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777)
NCT00265343 · start 2005-12
Registered record
- Registry ID
- NCT00265343
- Conditions
- Schizophrenia
- Interventions
- asenapine; olanzapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-12
- Completion
- 2008-01
- Enrolment
- 306
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionasenapine; olanzapinePhasePhase 3Registry statusCompletedLong-Term Efficacy and Safety of Asenapine Using Haloperidol as a Positive Control (41513)(COMPLETED)(P05785)
NCT00156065 · start 2005-09
Registered record
- Registry ID
- NCT00156065
- Conditions
- Schizophrenia
- Interventions
- Haloperidol; Asenapine; Asenapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-09
- Completion
- 2007-10
- Enrolment
- 187
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionHaloperidol; Asenapine; AsenapinePhasePhase 3Registry statusCompletedEfficacy and Safety of Asenapine With Placebo and Haloperidol (41023)(P05926)(COMPLETED)
NCT00156104 · start 2005-07-01
Registered record
- Registry ID
- NCT00156104
- Conditions
- Schizophrenia
- Interventions
- Asenapine; Asenapine; Haloperidol; Placebo arm
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-07-01
- Completion
- 2006-09-16
- Enrolment
- 460
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionAsenapine; Asenapine; Haloperidol; Placebo armPhasePhase 3Registry statusCompleted40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857)
NCT00159783 · start 2005-07
Registered record
- Registry ID
- NCT00159783
- Conditions
- Bipolar Disorder
- Interventions
- asenapine; Olanzapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-07
- Completion
- 2007-04
- Enrolment
- 218
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBipolar DisorderInterventionasenapine; OlanzapinePhasePhase 3Registry statusCompleted6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772)
NCT00174265 · start 2005-07
Registered record
- Registry ID
- NCT00174265
- Conditions
- Schizophrenia
- Interventions
- asenapine; olanzapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-07
- Completion
- 2009-05
- Enrolment
- 196
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionasenapine; olanzapinePhasePhase 3Registry statusCompleted12 Week Study of the Safety/Efficacy of Asenapine When Added to Lithium/Valproate in the Treatment of Bipolar Disorder (A7501008 / P05844 / MK-8274-017)
NCT00145470 · start 2005-06-02
Registered record
- Registry ID
- NCT00145470
- Conditions
- Bipolar Disorder
- Interventions
- Asenapine; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-06-02
- Completion
- 2007-03-22
- Enrolment
- 326
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBipolar DisorderInterventionAsenapine; PlaceboPhasePhase 3Registry statusCompletedEfficacy and Safety of Asenapine With Placebo and Olanzapine (41021)(P05933)
NCT00156117 · start 2005-05-12
Registered record
- Registry ID
- NCT00156117
- Conditions
- Schizophrenia
- Interventions
- asenapine; Placebo; olanzapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-05-12
- Completion
- 2006-05-30
- Enrolment
- 417
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionasenapine; Placebo; olanzapinePhasePhase 3Registry statusCompletedEfficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia (25543)(COMPLETED)(P05817)
NCT00212836 · start 2005-04-21
Registered record
- Registry ID
- NCT00212836
- Conditions
- Schizophrenia
- Interventions
- asenapine; olanzapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-04-21
- Completion
- 2007-08-02
- Enrolment
- 481
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionasenapine; olanzapinePhasePhase 3Registry statusCompletedLong-Term Efficacy and Safety of Asenapine Using Olanzapine as a Positive Control (41512)(COMPLETED)(P05784)
NCT00156091 · start 2005-04
Registered record
- Registry ID
- NCT00156091
- Conditions
- Schizophrenia
- Interventions
- Olanzapine; Asenapine; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-04
- Completion
- 2007-06
- Enrolment
- 260
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionOlanzapine; Asenapine; PlaceboPhasePhase 3Registry statusCompletedEfficacy and Safety of Asenapine With Placebo and Olanzapine (41022)(P05947)
NCT00151424 · start 2005-02-15
Registered record
- Registry ID
- NCT00151424
- Conditions
- Schizophrenia
- Interventions
- asenapine; Placebo; Olanzapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-02-15
- Completion
- 2006-02-06
- Enrolment
- 277
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionasenapine; Placebo; OlanzapinePhasePhase 3Registry statusCompleted9 Week Extension Study of Asenapine and Olanzapine in Treatment of Mania (P07007)(COMPLETED)
NCT00143182 · start 2005-01-07
Registered record
- Registry ID
- NCT00143182
- Conditions
- Bipolar Disorder
- Interventions
- Asenapine; Olanzapine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-01-07
- Completion
- 2006-06-28
- Enrolment
- 504
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBipolar DisorderInterventionAsenapine; OlanzapinePhasePhase 3Registry statusCompleted3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009)
NCT00159796 · start 2004-12-14
Registered record
- Registry ID
- NCT00159796
- Conditions
- Bipolar Disorder
- Interventions
- Asenapine; Olanzapine; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-12-14
- Completion
- 2006-04-28
- Enrolment
- 489
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBipolar DisorderInterventionAsenapine; Olanzapine; PlaceboPhasePhase 3Registry statusCompleted