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AMR Drug RepurposingSmart Screeningresearch prototype

Leucovorin Calcium

FDA-approved product (for solution, oral), marketed as Leucovorin Calcium, Leucovorin Calcium Preservative Free, Vykoura and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Leucovorin Calcium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Osteosarcoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Detoxifying agents for antineoplastic treatment
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Leucovorin Calcium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Leucovorin Calcium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma

    NCT02037048 · start 2014-02-10

    Registered record
    Registry ID
    NCT02037048
    Conditions
    Adenocarcinoma of the Esophagus; Adenocarcinoma of the Gastroesophageal Junction; Adenocarcinoma of the Gastric Cardia; Stage IIIA Esophageal Cancer; Stage IIIB Esophageal Cancer; Stage IIIC Esophageal Cancer
    Interventions
    oxaliplatin; leucovorin calcium; fluorouracil; therapeutic conventional surgery; radiation therapy; carboplatin; paclitaxel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2014-02-10
    Completion
    2025-10-01
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenocarcinoma of the Esophagus; Adenocarcinoma of the Gastroesophageal Junction; Adenocarcinoma of the Gastric Cardia; Stage IIIA Esophageal Cancer +2 more
    Interventionoxaliplatin; leucovorin calcium; fluorouracil; therapeutic conventional surgery +3 more
    PhasePhase 2
    Registry statusUnknown

  • CPI-613 and Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer

    NCT01835041 · start 2013-04

    Registered record
    Registry ID
    NCT01835041
    Conditions
    Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer
    Interventions
    6,8-bis(benzylthio)octanoic acid; oxaliplatin; leucovorin calcium; irinotecan hydrochloride; fluorouracil; laboratory biomarker analysis
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-04
    Completion
    2023-03-16
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer
    Intervention6,8-bis(benzylthio)octanoic acid; oxaliplatin; leucovorin calcium; irinotecan hydrochloride +2 more
    PhasePhase 1
    Registry statusCompleted

  • Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer

    NCT01666730 · start 2013-02-21

    Registered record
    Registry ID
    NCT01666730
    Conditions
    Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer
    Interventions
    metformin hydrochloride; oxaliplatin; leucovorin calcium; fluorouracil; laboratory biomarker analysis
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-02-21
    Completion
    2018-08-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer
    Interventionmetformin hydrochloride; oxaliplatin; leucovorin calcium; fluorouracil +1 more
    PhasePhase 2
    Registry statusCompleted

  • Liposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil as Second-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

    NCT01375816 · start 2011-05

    Registered record
    Registry ID
    NCT01375816
    Conditions
    Colorectal Cancer
    Interventions
    FOLFIRI 1-Bevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium; liposome-encapsulated irinotecan hydrochloride PEP02; Bevacizumab
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-05
    Completion
    2014-12
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    InterventionFOLFIRI 1-Bevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium +2 more
    PhasePhase 2
    Registry statusTerminated

  • Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers

    NCT01229111 · start 2010-10

    Registered record
    Registry ID
    NCT01229111
    Conditions
    Adult Primary Cholangiocellular Carcinoma; Advanced Adult Primary Liver Cancer; Cholangiocarcinoma of the Extrahepatic Bile Duct; Cholangiocarcinoma of the Gallbladder; Localized Unresectable Adult Primary Liver Cancer; Periampullary Adenocarcinoma; Recurrent Adult Primary Liver Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer
    Interventions
    cediranib maleate; oxaliplatin; leucovorin calcium; fluorouracil
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2010-10
    Completion
    2014-03
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Primary Cholangiocellular Carcinoma; Advanced Adult Primary Liver Cancer; Cholangiocarcinoma of the Extrahepatic Bile Duct; Cholangiocarcinoma of the Gallbladder +7 more
    Interventioncediranib maleate; oxaliplatin; leucovorin calcium; fluorouracil
    PhasePhase 2
    Registry statusTerminated

  • Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment

    NCT00942266 · start 2009-07

    Registered record
    Registry ID
    NCT00942266
    Conditions
    Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer
    Interventions
    fluorouracil; leucovorin calcium; vorinostat; pharmacological study
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-07
    Completion
    2011-12
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer +2 more
    Interventionfluorouracil; leucovorin calcium; vorinostat; pharmacological study
    PhasePhase 2
    Registry statusCompleted

  • Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery

    NCT00660894 · start 2008-04

    Registered record
    Registry ID
    NCT00660894
    Conditions
    Colorectal Cancer
    Interventions
    folinate calcium; tegafur-uracil; tegafur-gimeracil-oteracil potassium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-04
    Completion
    2015-07
    Enrolment
    1,535

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionfolinate calcium; tegafur-uracil; tegafur-gimeracil-oteracil potassium
    PhasePhase 3
    Registry statusCompleted

  • Systemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer

    NCT00769405 · start 2008-02

    Registered record
    Registry ID
    NCT00769405
    Conditions
    Colorectal Cancer; Primary Peritoneal Cavity Cancer
    Interventions
    fluorouracil; leucovorin calcium; oxaliplatin; hyperthermia treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-02
    Completion
    Not recorded
    Enrolment
    264

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer; Primary Peritoneal Cavity Cancer
    Interventionfluorouracil; leucovorin calcium; oxaliplatin; hyperthermia treatment
    PhasePhase 3
    Registry statusCompleted

  • Uracil and Tegafur/Leucovorin (UFT/LV) Versus UFT/LV+ Polysaccharide-K (PSK) for Stage IIIa/IIIb Colorectal Cancer

    NCT00497107 · start 2007-07

    Registered record
    Registry ID
    NCT00497107
    Conditions
    Colorectal Cancer
    Interventions
    UFT, Calcium Folinate, PSK; UFT, Calcium Folinate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2007-07
    Completion
    2013-05
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    InterventionUFT, Calcium Folinate, PSK; UFT, Calcium Folinate
    PhasePhase 3
    Registry statusUnknown

  • Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

    NCT00492999 · start 2007-05

    Registered record
    Registry ID
    NCT00492999
    Conditions
    Colorectal Cancer; Metastatic Cancer
    Interventions
    dexamethasone; floxuridine; fluorouracil; irinotecan hydrochloride; leucovorin calcium; oxaliplatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2007-05
    Completion
    2027-05
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer; Metastatic Cancer
    Interventiondexamethasone; floxuridine; fluorouracil; irinotecan hydrochloride +2 more
    PhasePhase 2
    Registry statusActive not recruiting

  • Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma

    NCT00392834 · start 2006-09

    Registered record
    Registry ID
    NCT00392834
    Conditions
    Lymphoma
    Interventions
    filgrastim; pegfilgrastim; rituximab; cyclophosphamide; cytarabine; doxorubicin hydrochloride; etoposide; ifosfamide; leucovorin calcium; liposomal cytarabine; methotrexate; therapeutic hydrocortisone; vincristine sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-09
    Completion
    2013-07
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    Interventionfilgrastim; pegfilgrastim; rituximab; cyclophosphamide +9 more
    PhasePhase 2
    Registry statusCompleted

  • Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

    NCT00618501 · start 2005-10

    Registered record
    Registry ID
    NCT00618501
    Conditions
    Leukemia
    Interventions
    cytarabine; daunorubicin hydrochloride; etoposide; imatinib mesylate; leucovorin calcium; methotrexate; prednisolone; therapeutic hydrocortisone; vincristine sulfate; allogeneic hematopoietic stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-10
    Completion
    2009-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia
    Interventioncytarabine; daunorubicin hydrochloride; etoposide; imatinib mesylate +6 more
    PhasePhase 2
    Registry statusCompleted

  • Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

    NCT00098787 · start 2005-09-08

    Registered record
    Registry ID
    NCT00098787
    Conditions
    Colorectal Cancer
    Interventions
    bevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium; Oxaliplatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-09-08
    Completion
    2015-04
    Enrolment
    247

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionbevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium +1 more
    PhasePhase 2
    Registry statusCompleted

  • Study of Rituximab-HCVAD Alternating With Rituximab-Methotrexate-Cytarabine Versus Standard Rituximab-CHOP Every 21 Days for Patients With Newly Diagnosed High Risk Aggressive B-Cell Non-Hodgkin's Lymphomas in Patients 60 Years Old or Younger

    NCT00290498 · start 2005-08-01

    Registered record
    Registry ID
    NCT00290498
    Conditions
    Lymphoma
    Interventions
    Rituximab; Cyclophosphamide; Doxorubicin; Vincristine; Dexamethasone; Methotrexate; Cytarabine; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-08-01
    Completion
    2017-08-11
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    InterventionRituximab; Cyclophosphamide; Doxorubicin; Vincristine +4 more
    PhasePhase 2
    Registry statusCompleted

  • Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer

    NCT00096278 · start 2004-09-15

    Registered record
    Registry ID
    NCT00096278
    Conditions
    Colon Adenocarcinoma; Stage IIA Colon Cancer AJCC v7; Stage IIB Colon Cancer AJCC v7; Stage IIC Colon Cancer AJCC v7; Stage IIIA Colon Cancer AJCC v7; Stage IIIB Colon Cancer AJCC v7; Stage IIIC Colon Cancer AJCC v7
    Interventions
    Bevacizumab; Fluorouracil; Leucovorin Calcium; Oxaliplatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-09-15
    Completion
    2012-12-31
    Enrolment
    2,710

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColon Adenocarcinoma; Stage IIA Colon Cancer AJCC v7; Stage IIB Colon Cancer AJCC v7; Stage IIC Colon Cancer AJCC v7 +3 more
    InterventionBevacizumab; Fluorouracil; Leucovorin Calcium; Oxaliplatin
    PhasePhase 3
    Registry statusCompleted