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AMR Drug RepurposingSmart Screeningresearch prototype

Triptorelin Pamoate

FDA-approved product (injectable, intramuscular), marketed as Trelstar, Triptodur Kit.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Triptorelin Pamoate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Central precocious puberty
  • Metastatic prostate cancer
  • Neoplasm
  • Precocious puberty
  • Prostate adenocarcinoma
  • Prostate carcinoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Gonadotropin releasing hormone analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA61.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis61.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triptorelin Pamoate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triptorelin Pamoate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)

    NCT04961996 · start 2021-08-27

    Registered record
    Registry ID
    NCT04961996
    Conditions
    Early Breast Cancer
    Interventions
    Giredestrant; Physician's Choice of Endocrine Therapy; LHRH Agonist
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    2021-08-27
    Completion
    2033-09-30
    Enrolment
    4,170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEarly Breast Cancer
    InterventionGiredestrant; Physician's Choice of Endocrine Therapy; LHRH Agonist
    PhasePhase 3
    Registry statusActive not recruiting

  • Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty.

    NCT04736602 · start 2021-03-27

    Registered record
    Registry ID
    NCT04736602
    Conditions
    Central Precocious Puberty
    Interventions
    Triptorelin pamoate 15mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-03-27
    Completion
    2022-09-03
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Precocious Puberty
    InterventionTriptorelin pamoate 15mg
    PhasePhase 3
    Registry statusCompleted

  • The Neoadjuvant Combined Hormone Therapy in Premenopausal Women With Locally Advanced ER+/HER2- Breast Cancer

    NCT04753177 · start 2021-01-28

    Registered record
    Registry ID
    NCT04753177
    Conditions
    The Neoadjuvant Therapy
    Interventions
    Ribocyclib, fulvestrant, triptorelin; Doxorubicin, cyclophosphamide, paclitaxel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2021-01-28
    Completion
    2024-01-28
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThe Neoadjuvant Therapy
    InterventionRibocyclib, fulvestrant, triptorelin; Doxorubicin, cyclophosphamide, paclitaxel
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

    NCT04513717 · start 2021-01-21

    Registered record
    Registry ID
    NCT04513717
    Conditions
    Prostate Adenocarcinoma; Stage III Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8
    Interventions
    Apalutamide; Bicalutamide; Biospecimen Collection; Bone Scan; Buserelin; Computed Tomography; Degarelix; Flutamide; Goserelin; Histrelin; Leuprolide; Magnetic Resonance Elastography; Positron Emission Tomography; Quality-of-Life Assessment; Questionnaire Administration; Radiation Therapy; Relugolix; Triptorelin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    2021-01-21
    Completion
    2038-12-31
    Enrolment
    2,753

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Adenocarcinoma; Stage III Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8
    InterventionApalutamide; Bicalutamide; Biospecimen Collection; Bone Scan +14 more
    PhasePhase 3
    Registry statusActive not recruiting

  • Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI

    NCT04727684 · start 2020-08-22

    Registered record
    Registry ID
    NCT04727684
    Conditions
    In Vitro Fertilization; Infertility; Intracytoplasmic Sperm Injection; Polycystic Ovary Syndrome
    Interventions
    Triptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-08-22
    Completion
    2022-05-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIn Vitro Fertilization; Infertility; Intracytoplasmic Sperm Injection; Polycystic Ovary Syndrome
    InterventionTriptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    PhasePhase 4
    Registry statusCompleted

  • Double Trigger in Patients With Low Proportion of Mature Oocytes

    NCT04407052 · start 2020-05-30

    Registered record
    Registry ID
    NCT04407052
    Conditions
    Infertility, Female
    Interventions
    Double trigger; HCG trigger
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2020-05-30
    Completion
    2021-02-02
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female
    InterventionDouble trigger; HCG trigger
    PhasePhase 2
    Registry statusUnknown

  • The Effect of Dual Trigger for Final Oocyte Maturation on IVF/ICSI Outcomes in Patients With Suboptimal Ovarian Response

    NCT04549649 · start 2019-11-01

    Registered record
    Registry ID
    NCT04549649
    Conditions
    Ovarian Stimulation; Reproductive Techniques, Assisted
    Interventions
    Dual triggering
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-11-01
    Completion
    2022-11-30
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Stimulation; Reproductive Techniques, Assisted
    InterventionDual triggering
    PhaseNot applicable
    Registry statusCompleted

  • A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery

    NCT03809000 · start 2019-04-15

    Registered record
    Registry ID
    NCT03809000
    Conditions
    Prostate Cancer
    Interventions
    Radiation Therapy; Enzalutamide; Bicalutamide; GnRH analog
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2019-04-15
    Completion
    2029-09-15
    Enrolment
    188

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionRadiation Therapy; Enzalutamide; Bicalutamide; GnRH analog
    PhasePhase 2
    Registry statusActive not recruiting

  • Trans-vaginal Aspiration of Small Ovarian Endometrioma. Comparison of Two Different Techniques Before ICSI

    NCT03784404 · start 2018-12

    Registered record
    Registry ID
    NCT03784404
    Conditions
    Ovarian Endometrioma
    Interventions
    Transvaginal aspiration; transvaginal aspiration and surgicel injection; Intracytoplasmic sperm injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-12
    Completion
    2019-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Endometrioma
    InterventionTransvaginal aspiration; transvaginal aspiration and surgicel injection; Intracytoplasmic sperm injection
    PhasePhase 4
    Registry statusUnknown

  • Deferred Versus Fresh Embryo Transfers

    NCT03349905 · start 2018-09-24

    Registered record
    Registry ID
    NCT03349905
    Conditions
    Infertility, Female
    Interventions
    fresh transfer; Deferred-frozen embryo transfer
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-09-24
    Completion
    2022-03-31
    Enrolment
    237

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female
    Interventionfresh transfer; Deferred-frozen embryo transfer
    PhaseNot applicable
    Registry statusCompleted

  • A Salvage Trial of AR Inhibition With ADT and Apalutamide With Radiation Therapy Followed by Docetaxel in Men With PSA Recurrent Prostate Cancer After Radical Prostatectomy (STARTAR)

    NCT03311555 · start 2018-03-28

    Registered record
    Registry ID
    NCT03311555
    Conditions
    Prostate Cancer
    Interventions
    Apalutamide; Androgen deprivation; Salvage radiation therapy; Docetaxel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-03-28
    Completion
    2022-12-22
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionApalutamide; Androgen deprivation; Salvage radiation therapy; Docetaxel
    PhasePhase 2
    Registry statusCompleted

  • Early Preparation With Gonadotropin- Releasing Hormon (GnRh) Agonists Injection With Frozen-Thawed Embryo Transfer?

    NCT03353883 · start 2017-06-01

    Registered record
    Registry ID
    NCT03353883
    Conditions
    Infertility, Female
    Interventions
    Triptorelin SR
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2017-06-01
    Completion
    2018-08
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female
    InterventionTriptorelin SR
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Supportive Therapy in Androgen Deprivation Clinic in Improving Health Outcomes and Managing Side Effects in Patients With Prostate Cancer

    NCT02168062 · start 2014-06-16

    Registered record
    Registry ID
    NCT02168062
    Conditions
    Prostate Adenocarcinoma
    Interventions
    Behavioral Dietary Intervention; Counseling; Educational Intervention; Exercise Intervention; Goserelin Acetate; Laboratory Biomarker Analysis; Leuprolide Acetate; Quality-of-Life Assessment; Triptorelin Pamoate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2014-06-16
    Completion
    2018-05-22
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Adenocarcinoma
    InterventionBehavioral Dietary Intervention; Counseling; Educational Intervention; Exercise Intervention +5 more
    PhasePhase 2
    Registry statusTerminated

  • GnRH Agonist Trigger and Modified Luteal Phase Support, Adding a Bolus of GnRHa at the Time of Implantation - a RCT

    NCT02053779 · start 2014-03

    Registered record
    Registry ID
    NCT02053779
    Conditions
    Infertility
    Interventions
    Triptorelin 0.1mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-03
    Completion
    2017-03
    Enrolment
    328

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionTriptorelin 0.1mg
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders

    NCT01926210 · start 2013-09

    Registered record
    Registry ID
    NCT01926210
    Conditions
    Infertility
    Interventions
    mild stimulation protocol; controlled ovarian stimulation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-09
    Completion
    2016-09
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    Interventionmild stimulation protocol; controlled ovarian stimulation
    PhasePhase 4
    Registry statusUnknown