Lubiprostone
FDA-approved product (capsule, oral), marketed as Amitiza, Lubiprostone.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Chronic pain
- Constipation
- Constipation disorder
- Irritable bowel syndrome
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Other drugs for constipation
- FDA pharmacologic class
- Chloride Channel Activator FDA label ↗
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA51.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli28.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis24.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Lubiprostone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Trimetrexate GlucuronateExisting use: Other agents against amoebiasis and other protozoal diseases88.6% AI-predicted activityagainst E. coliLab records exist17 registered studies
- Folic AcidExisting use: Acne, Anemia, Anemia (phenotype) and 8 more87.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- MethotrexateExisting use: Acute lymphoblastic leukemia, Adenoma, Arthritis and 21 more86.8% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- PralatrexateExisting use: Cancer, Mature T-cell and NK-cell non-Hodgkin lymphoma, Neoplasm and 2 more82.2% AI-predicted activityagainst E. coli44 registered studies
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives81.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Leucovorin CalciumExisting use: Osteosarcoma67.6% AI-predicted activityagainst E. coli50+ registered studies
- LevoleucovorinExisting use: Anemia, Colorectal adenocarcinoma, Colorectal cancer and 3 more67.6% AI-predicted activityagainst E. coli50+ registered studies
- PyrimethamineExisting use: Malaria, Toxoplasmosis64.6% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Copanlisib DihydrochlorideExisting use: Follicular lymphoma, Neoplasm, Neoplasm of mature B-cells63.5% AI-predicted activityagainst E. coli10 registered studies
- AfamelanotideExisting use: Erythropoietic protoporphyria62.6% AI-predicted activityagainst E. coli23 registered studies
- Rimegepant SulfateExisting use: Migraine disorder61.6% AI-predicted activityagainst E. coli50+ registered studies
- Histrelin AcetateExisting use: Neoplasm, Prostate adenocarcinoma, Prostate cancer61.6% AI-predicted activityagainst E. coli13 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Intestinal Microecology in Chronic Constipation
NCT00934479 · start 2010-04
Registered record
- Registry ID
- NCT00934479
- Conditions
- Other Constipation; Irritable Bowel Syndrome
- Interventions
- Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2010-04
- Completion
- 2012-02
- Enrolment
- 21
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionOther Constipation; Irritable Bowel SyndromeInterventionLubiprostonePhasePhase 1Registry statusCompletedA Trial Comparing Split-Dose Miralax With Amitiza Pretreatment Versus Dulcolax Pretreatment Versus Golytely for Bowel Cleansing Prior to Colonoscopy
NCT00953017 · start 2009-07
Registered record
- Registry ID
- NCT00953017
- Conditions
- Colonoscopy
- Interventions
- Miralax (PEG 3350); Amitiza (Lubiprostone); Dulcolax (Bisacodyl); Golytely (polyethylene glycol)
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2009-07
- Completion
- 2010-05
- Enrolment
- 425
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColonoscopyInterventionMiralax (PEG 3350); Amitiza (Lubiprostone); Dulcolax (Bisacodyl); Golytely (polyethylene glycol)PhasePhase 4Registry statusCompletedLubiprostone as a Treatment for Constipation in Parkinson's Disease
NCT00669461 · start 2009-06
Registered record
- Registry ID
- NCT00669461
- Conditions
- Constipation; Parkinson's Disease
- Interventions
- Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Terminated
- Start
- 2009-06
- Completion
- 2010-09
- Enrolment
- 1
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionConstipation; Parkinson's DiseaseInterventionLubiprostonePhaseNot applicableRegistry statusTerminatedEffects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit
NCT00844831 · start 2009-05
Registered record
- Registry ID
- NCT00844831
- Conditions
- Constipation
- Interventions
- Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2009-05
- Completion
- 2011-05
- Enrolment
- 25
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionConstipationInterventionLubiprostonePhasePhase 4Registry statusCompletedEffect of Lubiprostone on Methanogenesis and Bowel Function in Chronic Constipation.
NCT01190020 · start 2009-02
Registered record
- Registry ID
- NCT01190020
- Conditions
- Chronic Constipation, Methanogenesis
- Interventions
- Lubiprostone; Lubiprostone Control
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2009-02
- Completion
- 2012-03
- Enrolment
- 41
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Constipation, MethanogenesisInterventionLubiprostone; Lubiprostone ControlPhasePhase 1Registry statusCompletedShort Term Safety and Efficacy of Lubiprostone in Adults With Cystic Fibrosis
NCT00706004 · start 2008-07
Registered record
- Registry ID
- NCT00706004
- Conditions
- Constipation; Cystic Fibrosis
- Interventions
- lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2008-07
- Completion
- 2009-12
- Enrolment
- 9
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionConstipation; Cystic FibrosisInterventionlubiprostonePhaseNot applicableRegistry statusCompletedEfficacy of Lubiprostone in Combination With Standard PEG Preparation
NCT00689026 · start 2008-05
Registered record
- Registry ID
- NCT00689026
- Conditions
- Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
- Interventions
- Lubiprostone; Polyethylene glycol with electrolytes
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Terminated
- Start
- 2008-05
- Completion
- 2010-03
- Enrolment
- 60
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionDiabetes Mellitus, Type 1; Diabetes Mellitus, Type 2InterventionLubiprostone; Polyethylene glycol with electrolytesPhaseNot applicableRegistry statusTerminatedRandomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy
NCT00746395 · start 2008-04
Registered record
- Registry ID
- NCT00746395
- Conditions
- Inflammatory Bowel Disease
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2008-04
- Completion
- 2008-09
- Enrolment
- 45
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionInflammatory Bowel DiseaseInterventionLubiprostone; PlaceboPhasePhase 4Registry statusCompletedAmitiza® Plus GoLYTELY® (PEG) Versus Placebo Plus GoLYTELY® for Outpatient Colonoscopy Preparation
NCT00645801 · start 2008-03
Registered record
- Registry ID
- NCT00645801
- Conditions
- Colonoscopy
- Interventions
- lubiprostone (Amitiza); Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2008-03
- Completion
- 2011-07
- Enrolment
- 158
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColonoscopyInterventionlubiprostone (Amitiza); PlaceboPhasePhase 4Registry statusCompletedLubiprostone Effects on Visceral Pain Sensitivity
NCT01166789 · start 2008-02
Registered record
- Registry ID
- NCT01166789
- Conditions
- Irritable Bowel Syndrome
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2008-02
- Completion
- 2010-08
- Enrolment
- 62
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIrritable Bowel SyndromeInterventionLubiprostone; PlaceboPhasePhase 1Registry statusCompletedOpioid-induced Bowel Dysfunction: Long-Term Assessment of Lubiprostone
NCT00620061 · start 2007-12
Registered record
- Registry ID
- NCT00620061
- Conditions
- Opioid-Induced Bowel Dysfunction
- Interventions
- Lubiprostone 24
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2007-12
- Completion
- 2009-09
- Enrolment
- 439
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionOpioid-Induced Bowel DysfunctionInterventionLubiprostone 24PhasePhase 3Registry statusCompletedEffect of Lubiprostone on Nutritional Status and Pulmonary Function in Adults With Cystic Fibrosis
NCT00577499 · start 2007-10
Registered record
- Registry ID
- NCT00577499
- Conditions
- Cystic Fibrosis; Constipation; Nutrition
- Interventions
- Not recorded
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Terminated
- Start
- 2007-10
- Completion
- 2009-06
- Enrolment
- 7
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCystic Fibrosis; Constipation; NutritionInterventionNot recordedPhaseNot recordedRegistry statusTerminatedSplit Dose Golytely With Amitiza Pretreatment Versus Split Dose Golytely Plus Placebo in Outpatient Colonoscopy
NCT00611442 · start 2007-10
Registered record
- Registry ID
- NCT00611442
- Conditions
- Bowel Preparation for Colonoscopy
- Interventions
- lubiprostone; placebo
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2007-10
- Completion
- 2008-01
- Enrolment
- 191
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBowel Preparation for ColonoscopyInterventionlubiprostone; placeboPhaseNot applicableRegistry statusCompletedLubiprostone, Colonic Motility and Sensation
NCT00953043 · start 2007-09
Registered record
- Registry ID
- NCT00953043
- Conditions
- Healthy
- Interventions
- lubiprostone; Placebo; Bowel preparation
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2007-09
- Completion
- 2009-07
- Enrolment
- 60
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthyInterventionlubiprostone; Placebo; Bowel preparationPhasePhase 4Registry statusCompletedEffects of Lubiprostone on Gastric Function in Patients With Chronic Idiopathic Constipation
NCT01460225 · start 2007-09
Registered record
- Registry ID
- NCT01460225
- Conditions
- Chronic Idiopathic Constipation
- Interventions
- lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2007-09
- Completion
- 2011-01
- Enrolment
- 19
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Idiopathic ConstipationInterventionlubiprostonePhasePhase 4Registry statusCompleted