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AMR Drug RepurposingSmart Screeningresearch prototype

Pyrimethamine

FDA-approved product (tablet, oral), marketed as Daraprim, Pyrimethamine.

Registered studies
50+
Lab records
9
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Pyrimethamine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Malaria
  • Toxoplasmosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Diaminopyrimidines
FDA pharmacologic class
Dihydrofolate Reductase Inhibitor Antimalarial FDA label ↗
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC P01BD01; WHO ATC P01BD51; FDA class Dihydrofolate Reductase Inhibitor Antimalarial

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli64.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae11.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • E. coli: measured active in 9 of 9 lab records
Open Pyrimethamine in ChEMBL Registered studies below
Show the 9 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Pyrimethamine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)

    NCT03143218 · start 2017-04-17

    Registered record
    Registry ID
    NCT03143218
    Conditions
    Malaria,Falciparum; Children, Only
    Interventions
    RABIPUR®; RTS,S/AS01; SMC with SP+AQ; SMC placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-04-17
    Completion
    2020-03-31
    Enrolment
    5,920

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria,Falciparum; Children, Only
    InterventionRABIPUR®; RTS,S/AS01; SMC with SP+AQ; SMC placebo
    PhasePhase 3
    Registry statusCompleted

  • Prevention of Malaria in HIV-uninfected Pregnant Women and Infants

    NCT02793622 · start 2016-09

    Registered record
    Registry ID
    NCT02793622
    Conditions
    Malaria
    Interventions
    Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy; Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-09
    Completion
    2018-12-04
    Enrolment
    782

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionMonthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy; Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy
    PhasePhase 3
    Registry statusCompleted

  • Seasonal Malaria Chemoprevention With or Without Lipid-based Nutrient Supplement in Children Aged 6-59 Months in Mali

    NCT03035305 · start 2016-08

    Registered record
    Registry ID
    NCT03035305
    Conditions
    Malaria
    Interventions
    Lipid-based Nutrient Supplement (LNS); Seasonal malaria chemoprevention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-08
    Completion
    2016-11
    Enrolment
    36,717

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionLipid-based Nutrient Supplement (LNS); Seasonal malaria chemoprevention
    PhaseNot applicable
    Registry statusCompleted

  • Phase 2 Efficacy Study of Primaquine and Methylene Blue

    NCT02831023 · start 2016-07

    Registered record
    Registry ID
    NCT02831023
    Conditions
    Malaria
    Interventions
    Sulphadoxine-pyrimethamine; 0.25 mg/kg primaquine; Dihydroartemisinin-piperaquine; Methylene blue; Amodiaquine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-07
    Completion
    2017-01
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionSulphadoxine-pyrimethamine; 0.25 mg/kg primaquine; Dihydroartemisinin-piperaquine; Methylene blue +1 more
    PhasePhase 2
    Registry statusCompleted

  • A Study to Assess Current Standard Malaria Treatment Guidelines in the Republic of the Sudan

    NCT02592408 · start 2015-11

    Registered record
    Registry ID
    NCT02592408
    Conditions
    Malaria
    Interventions
    ASP; SDPQ; 14DPQ; 14DPQ on Day 42
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-11
    Completion
    2016-05
    Enrolment
    320

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionASP; SDPQ; 14DPQ; 14DPQ on Day 42
    PhasePhase 4
    Registry statusCompleted

  • Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants

    NCT02163447 · start 2014-06-23

    Registered record
    Registry ID
    NCT02163447
    Conditions
    Malaria
    Interventions
    Monthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy; Monthly dihydroartemisinin-piperaquine (DP) for infants; 3-monthly dihydroartemisinin-piperaquine (DP) for infants
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-06-23
    Completion
    2018-05-14
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionMonthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy; 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy; Monthly dihydroartemisinin-piperaquine (DP) for infants +1 more
    PhasePhase 3
    Registry statusCompleted

  • Package of Interventions After Recovering From Moderate Acute Malnutrition

    NCT02351687 · start 2014-04

    Registered record
    Registry ID
    NCT02351687
    Conditions
    Malnutrition
    Interventions
    Lipid Nutrient Supplement; Sulfadoxine-pyrimethamine; Albendazole; Zinc; Insecticide-treated bednet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-04
    Completion
    2016-06
    Enrolment
    1,499

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalnutrition
    InterventionLipid Nutrient Supplement; Sulfadoxine-pyrimethamine; Albendazole; Zinc +1 more
    PhaseNot applicable
    Registry statusCompleted

  • SPK Study in Afghanistan

    NCT01707199 · start 2012-10

    Registered record
    Registry ID
    NCT01707199
    Conditions
    Uncomplicated P. Falciparum Malaria
    Interventions
    Artesunate + Sulphadoxine-pyrimethamine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-10
    Completion
    2014-01
    Enrolment
    83

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUncomplicated P. Falciparum Malaria
    InterventionArtesunate + Sulphadoxine-pyrimethamine
    PhaseNot applicable
    Registry statusCompleted

  • Trial of Malaria Seasonal IPTc Combined With Community Case Management

    NCT01449045 · start 2011-07

    Registered record
    Registry ID
    NCT01449045
    Conditions
    Malaria
    Interventions
    IPTc+CCM; Community Case Management with artemether-lumefantrine (AL)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-07
    Completion
    2012-02
    Enrolment
    4,554

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionIPTc+CCM; Community Case Management with artemether-lumefantrine (AL)
    PhasePhase 3
    Registry statusCompleted

  • Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda

    NCT01184911 · start 2010-10

    Registered record
    Registry ID
    NCT01184911
    Conditions
    Intermittent Preventive Treatment; Placental Malaria
    Interventions
    Sulfadoxine-pyrimethamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2010-10
    Completion
    2011-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntermittent Preventive Treatment; Placental Malaria
    InterventionSulfadoxine-pyrimethamine
    PhasePhase 4
    Registry statusWithdrawn

  • Impact of IPT With Sulfadoxin Pyrimetamin on Pregnant Women and Their Babies Outcomes in Peri-urban Areas of Bobo-Dioulasso(Burkina Faso)

    NCT01255605 · start 2010-09

    Registered record
    Registry ID
    NCT01255605
    Conditions
    Malaria, Pregnancy
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-06
    Enrolment
    772

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria, Pregnancy
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Chemopreventive Therapy for Malaria in Ugandan Children

    NCT00948896 · start 2010-06

    Registered record
    Registry ID
    NCT00948896
    Conditions
    Malaria
    Interventions
    trimethoprim-sulfamethoxazole (TS; TMP/SMX); sulfadoxine-pyrimethamine (SP); dihydroartemisinin-piperaquine (DP)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-06
    Completion
    2014-04
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    Interventiontrimethoprim-sulfamethoxazole (TS; TMP/SMX); sulfadoxine-pyrimethamine (SP); dihydroartemisinin-piperaquine (DP)
    PhasePhase 3
    Registry statusCompleted

  • A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands

    NCT00964691 · start 2009-08

    Registered record
    Registry ID
    NCT00964691
    Conditions
    Malaria; Malaria in Pregnancy
    Interventions
    Sulphadoxine-pyrimethamine; Chloroquine prophylaxis
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-08
    Completion
    2010-08
    Enrolment
    2,504

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Malaria in Pregnancy
    InterventionSulphadoxine-pyrimethamine; Chloroquine prophylaxis
    PhasePhase 4
    Registry statusTerminated

  • Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease)

    NCT01102686 · start 2009-08

    Registered record
    Registry ID
    NCT01102686
    Conditions
    Gangliosidoses, GM2; Sandhoff Disease; Tay-Sachs Disease
    Interventions
    Pyrimethamine; Leucovorin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2009-08
    Completion
    2010-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGangliosidoses, GM2; Sandhoff Disease; Tay-Sachs Disease
    InterventionPyrimethamine; Leucovorin
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Artesunate Plus Sulfadoxine-pyrimethamine Pharmacokinetics, Efficacy, Gametocytes Carriage and Birth Outcomes in Pregnant Women With Malaria

    NCT00331708 · start 2006-04

    Registered record
    Registry ID
    NCT00331708
    Conditions
    Malaria
    Interventions
    Artesunate plus sulfadoxine-pyrimethamine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2006-04
    Completion
    2007-07
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionArtesunate plus sulfadoxine-pyrimethamine
    PhaseNot applicable
    Registry statusTerminated