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AMR Drug RepurposingSmart Screeningresearch prototype

Tadalafil

FDA-approved product (tablet, oral), marketed as Adcirca, Alyq, Chewtadzy and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Tadalafil
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Benign prostatic hyperplasia
  • Erectile dysfunction
  • Impotence
  • Pulmonary arterial hypertension
  • Pulmonary hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Drugs used in erectile dysfunction
FDA pharmacologic class
Phosphodiesterase 5 Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli30.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tadalafil in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-10.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tadalafil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Chemoimmunotherapy and Radiation in Pancreatic Cancer

    NCT01903083 · start 2013-07

    Registered record
    Registry ID
    NCT01903083
    Conditions
    Locally Advanced Malignant Neoplasm
    Interventions
    Tadalafil; Gemcitabine; Radiation; Pancreaticoduodenectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-07
    Completion
    2017-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLocally Advanced Malignant Neoplasm
    InterventionTadalafil; Gemcitabine; Radiation; Pancreaticoduodenectomy
    PhasePhase 1
    Registry statusCompleted

  • A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension

    NCT01484431 · start 2012-07-17

    Registered record
    Registry ID
    NCT01484431
    Conditions
    Pulmonary Arterial Hypertension
    Interventions
    Tadalafil- Tablet or Oral suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2012-07-17
    Completion
    2019-04-03
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Arterial Hypertension
    InterventionTadalafil- Tablet or Oral suspension
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Phase 3 Study of Tadalafil Once-Daily in Asian Men With Benign Prostatic Hyperplasia (BPH)

    NCT01460342 · start 2011-12

    Registered record
    Registry ID
    NCT01460342
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Tadalafil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-12
    Completion
    2012-10
    Enrolment
    610

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionTadalafil; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Tadalafil and Sildenafil for Duchenne Muscular Dystrophy

    NCT01359670 · start 2011-05

    Registered record
    Registry ID
    NCT01359670
    Conditions
    Duchenne Muscular Dystrophy
    Interventions
    Tadalafil; Sildenafil
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2011-05
    Completion
    2013-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDuchenne Muscular Dystrophy
    InterventionTadalafil; Sildenafil
    PhaseEarly phase 1
    Registry statusCompleted

  • Aortic Stenosis and PhosphodiEsterase iNhibition With Aortic Valve Replacement (ASPEN-AVR): A Pilot Study

    NCT01272388 · start 2011-01

    Registered record
    Registry ID
    NCT01272388
    Conditions
    Aortic Stenosis
    Interventions
    Tadalafil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2011-01
    Completion
    2012-04
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Stenosis
    InterventionTadalafil; Placebo
    PhasePhase 4
    Registry statusTerminated

  • A Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

    NCT01178073 · start 2010-10-01

    Registered record
    Registry ID
    NCT01178073
    Conditions
    Hypertension, Pulmonary
    Interventions
    ambrisentan; tadalafil
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-10-01
    Completion
    2014-07-31
    Enrolment
    610

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension, Pulmonary
    Interventionambrisentan; tadalafil
    PhasePhase 3
    Registry statusCompleted

  • A Study of Tadalafil Use With Finasteride in Men With Enlarged Prostates and Urinary Symptoms

    NCT01139762 · start 2010-09

    Registered record
    Registry ID
    NCT01139762
    Conditions
    Benign Prostatic Hyperplasia; Enlarged Prostate
    Interventions
    Tadalafil; Placebo; Finasteride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-09
    Completion
    2012-05
    Enrolment
    696

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia; Enlarged Prostate
    InterventionTadalafil; Placebo; Finasteride
    PhasePhase 3
    Registry statusCompleted

  • A Study in Benign Prostatic Hyperplasia

    NCT01152190 · start 2010-09

    Registered record
    Registry ID
    NCT01152190
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Tadalafil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-09
    Completion
    2012-07
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionTadalafil; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Do Phosphodiesterase 5A Inhibitors Improve Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Pulmonary Hypertension?

    NCT01197469 · start 2010-09

    Registered record
    Registry ID
    NCT01197469
    Conditions
    Chronic Obstructive Pulmonary Disease; Pulmonary Hypertension
    Interventions
    Tadalafil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-09
    Completion
    2012-09
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease; Pulmonary Hypertension
    InterventionTadalafil; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Tadalafil Effects in Left Ventricle Diastolic Dysfunction in Resistant Hypertensive Patients

    NCT01743911 · start 2010-09

    Registered record
    Registry ID
    NCT01743911
    Conditions
    Hypertension
    Interventions
    sugar pill; Tadalafil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-09
    Completion
    2012-08
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionsugar pill; Tadalafil
    PhaseNot applicable
    Registry statusCompleted

  • A Study in Patients With Erectile Dysfunction

    NCT01122264 · start 2010-05

    Registered record
    Registry ID
    NCT01122264
    Conditions
    Erectile Dysfunction
    Interventions
    Tadalafil; Sildenafil Citrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-05
    Completion
    2011-06
    Enrolment
    770

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction
    InterventionTadalafil; Sildenafil Citrate
    PhasePhase 4
    Registry statusCompleted

  • A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors

    NCT01131104 · start 2010-05

    Registered record
    Registry ID
    NCT01131104
    Conditions
    Nonarteritic Anterior Ischemic Optic Neuropathy
    Interventions
    PDE5 Inhibitors
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-05
    Completion
    2015-12
    Enrolment
    345

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNonarteritic Anterior Ischemic Optic Neuropathy
    InterventionPDE5 Inhibitors
    PhaseNot recorded
    Registry statusCompleted

  • Sildenafil to Tadalafil in Pulmonary Arterial Hypertension (SITAR)

    NCT01043627 · start 2009-12

    Registered record
    Registry ID
    NCT01043627
    Conditions
    Pulmonary Arterial Hypertension
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-12
    Completion
    2011-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Arterial Hypertension
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma

    NCT01117298 · start 2009-11

    Registered record
    Registry ID
    NCT01117298
    Conditions
    Raynaud's Phenomenon; Digital Ulcers; Scleroderma
    Interventions
    Tadalafil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-11
    Completion
    2010-05
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRaynaud's Phenomenon; Digital Ulcers; Scleroderma
    InterventionTadalafil; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Tadalafil in Treating Patients Undergoing Surgery for Cancer of the Oral Cavity or Oropharynx

    NCT00843635 · start 2008-09

    Registered record
    Registry ID
    NCT00843635
    Conditions
    Head and Neck Cancer
    Interventions
    Tadalafil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-09
    Completion
    2015-04
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHead and Neck Cancer
    InterventionTadalafil; Placebo
    PhaseNot applicable
    Registry statusCompleted