Adefovir Dipivoxil
FDA-approved product (tablet, oral), marketed as Adefovir Dipivoxil, Hepsera.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Chronic hepatitis B virus infection
- Hepatitis B virus infection
- Viral disease
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Nucleoside and nucleotide reverse transcriptase inhibitors
- Anti-infective classification
- Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AF08
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA28.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae31.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis49.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Adefovir Dipivoxil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Trimetrexate GlucuronateExisting use: Other agents against amoebiasis and other protozoal diseases88.6% AI-predicted activityagainst E. coliLab records exist17 registered studies
- Folic AcidExisting use: Acne, Anemia, Anemia (phenotype) and 8 more87.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- MethotrexateExisting use: Acute lymphoblastic leukemia, Adenoma, Arthritis and 21 more86.8% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- PralatrexateExisting use: Cancer, Mature T-cell and NK-cell non-Hodgkin lymphoma, Neoplasm and 2 more82.2% AI-predicted activityagainst E. coli44 registered studies
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives81.0% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Leucovorin CalciumExisting use: Osteosarcoma67.6% AI-predicted activityagainst E. coli50+ registered studies
- LevoleucovorinExisting use: Anemia, Colorectal adenocarcinoma, Colorectal cancer and 3 more67.6% AI-predicted activityagainst E. coli50+ registered studies
- PyrimethamineExisting use: Malaria, Toxoplasmosis64.6% AI-predicted activityagainst E. coliLab records exist50+ registered studies
- Copanlisib DihydrochlorideExisting use: Follicular lymphoma, Neoplasm, Neoplasm of mature B-cells63.5% AI-predicted activityagainst E. coli10 registered studies
- AfamelanotideExisting use: Erythropoietic protoporphyria62.6% AI-predicted activityagainst E. coli23 registered studies
- Rimegepant SulfateExisting use: Migraine disorder61.6% AI-predicted activityagainst E. coli50+ registered studies
- Histrelin AcetateExisting use: Neoplasm, Prostate adenocarcinoma, Prostate cancer61.6% AI-predicted activityagainst E. coli13 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Adefovir Dipivoxil For The Treatment Of Patients With Chronic Hepatitis B Related Advanced Fibrosis Or Cirrhosis
NCT00347009 · start 2005-05
Registered record
- Registry ID
- NCT00347009
- Conditions
- Hepatitis B, Chronic; Cirrhosis; Fibrosis; Chronic Hepatitis B
- Interventions
- adefovir dipivoxil
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2005-05
- Completion
- 2009-09
- Enrolment
- 155
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHepatitis B, Chronic; Cirrhosis; Fibrosis; Chronic Hepatitis BInterventionadefovir dipivoxilPhasePhase 4Registry statusCompletedAn Open Label, Multi Centre Phase IV Study of Adefovir Dipivoxil in Korean Patients With Chronic Hepatitis B (CHB)
NCT01205165 · start 2004-12-17
Registered record
- Registry ID
- NCT01205165
- Conditions
- Hepatitis B, Chronic
- Interventions
- Adefor dipivoxil
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2004-12-17
- Completion
- 2006-04-28
- Enrolment
- 104
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHepatitis B, ChronicInterventionAdefor dipivoxilPhasePhase 4Registry statusCompletedEvaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes, Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a
NCT00199732 · start 2004-12
Registered record
- Registry ID
- NCT00199732
- Conditions
- Chronic Hepatitis B
- Interventions
- Not recorded
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2004-12
- Completion
- 2009-07
- Enrolment
- 19
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Hepatitis BInterventionNot recordedPhaseNot recordedRegistry statusCompletedTelbivudine Versus Adefovir Dipivoxil in Adults With HBegAg-Positive, Compensated Chronic Hepatitis B
NCT00115245 · start 2004-11
Registered record
- Registry ID
- NCT00115245
- Conditions
- Chronic Hepatitis B
- Interventions
- Telbivudine (LdT); Adefovir Dipivoxil
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-11
- Completion
- 2006-08
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Hepatitis BInterventionTelbivudine (LdT); Adefovir DipivoxilPhasePhase 3Registry statusCompletedHEPSERA Post Marketing Surveillance
NCT01329419 · start 2004-08
Registered record
- Registry ID
- NCT01329419
- Conditions
- Hepatitis B
- Interventions
- adefovir dipivoxil
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2004-08
- Completion
- 2010-02
- Enrolment
- 4,393
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHepatitis BInterventionadefovir dipivoxilPhaseNot recordedRegistry statusCompletedSafety and Efficacy of Adefovir Dipivoxil in Children and Adolescents With Chronic Hepatitis B
NCT00095121 · start 2004-06
Registered record
- Registry ID
- NCT00095121
- Conditions
- Chronic Hepatitis B
- Interventions
- Placebo (PLB); Adefovir Dipivoxil (ADV); Lamivudine
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-06
- Completion
- 2010-04
- Enrolment
- 173
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Hepatitis BInterventionPlacebo (PLB); Adefovir Dipivoxil (ADV); LamivudinePhasePhase 3Registry statusCompletedSafety and Efficacy Study of LB80380 in the Patients With Lamivudine-Refractory Chronic Hepatitis B
NCT00895596 · start 2004-03
Registered record
- Registry ID
- NCT00895596
- Conditions
- Chronic Hepatitis B
- Interventions
- LB80380
- Study type
- INTERVENTIONAL
- Phase
- Phase 1 / Phase 2
- Registry status
- Completed
- Start
- 2004-03
- Completion
- 2007-12
- Enrolment
- 65
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Hepatitis BInterventionLB80380PhasePhase 1 / Phase 2Registry statusCompletedLamivudine and Adefovir to Treat Chronic Hepatitis B Infection in People With and Without HIV Infection
NCT00023153 · start 2001-08
Registered record
- Registry ID
- NCT00023153
- Conditions
- HIV Infections; Chronic Hepatitis B
- Interventions
- Adefovir Dipivoxil
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2001-08
- Completion
- 2004-10
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV Infections; Chronic Hepatitis BInterventionAdefovir DipivoxilPhasePhase 3Registry statusCompletedLamivudine and Adefovir to Treat Chronic Hepatitis B
NCT00023309 · start 2001-08
Registered record
- Registry ID
- NCT00023309
- Conditions
- HBV (Hepatitis B Virus); Hepatitis B; Hepatitis
- Interventions
- Lamivudine and adefovir; Adefovir alone
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2001-08
- Completion
- 2013-08
- Enrolment
- 41
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHBV (Hepatitis B Virus); Hepatitis B; HepatitisInterventionLamivudine and adefovir; Adefovir alonePhasePhase 2Registry statusCompletedAdefovir Dipivoxil to Treat Hepatitis B in HIV-Infected Patients
NCT00013702 · start 2001-03
Registered record
- Registry ID
- NCT00013702
- Conditions
- Hepatitis B; HIV Infection
- Interventions
- Adefovir
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2001-03
- Completion
- 2004-02
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHepatitis B; HIV InfectionInterventionAdefovirPhasePhase 2Registry statusCompletedThe Safety and Effectiveness of Adefovir Dipivoxil in the Treatment of HIV-Infected Patients
NCT00001082 · start 1996-12
Registered record
- Registry ID
- NCT00001082
- Conditions
- Cytomegalovirus Infections; HIV Infections
- Interventions
- Levocarnitine; Adefovir dipivoxil; Adefovir dipivoxil placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 1996-12
- Completion
- 1999-08
- Enrolment
- 505
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCytomegalovirus Infections; HIV InfectionsInterventionLevocarnitine; Adefovir dipivoxil; Adefovir dipivoxil placeboPhasePhase 3Registry statusCompletedThe Safety and Effectiveness of Adefovir Dipivoxil in HIV-Infected Children
NCT00000843
Registered record
- Registry ID
- NCT00000843
- Conditions
- HIV Infections
- Interventions
- Adefovir dipivoxil
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionAdefovir dipivoxilPhasePhase 1Registry statusCompletedA Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir
NCT00000892
Registered record
- Registry ID
- NCT00000892
- Conditions
- HIV Infections
- Interventions
- Ritonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Delavirdine mesylate
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 1999-08
- Enrolment
- 300
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionRitonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil +2 morePhaseNot applicableRegistry statusCompletedA Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients
NCT00000912
Registered record
- Registry ID
- NCT00000912
- Conditions
- HIV Infections
- Interventions
- Indinavir sulfate; Abacavir sulfate; Amprenavir; Nelfinavir mesylate; Efavirenz; Levocarnitine; Adefovir dipivoxil; Saquinavir
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2000-05
- Enrolment
- 475
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionIndinavir sulfate; Abacavir sulfate; Amprenavir; Nelfinavir mesylate +4 morePhasePhase 2Registry statusCompletedA Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Adefovir Dipivoxil When Added to Standard Antiretroviral Therapy for the Treatment of HIV-Infected Patients With CD4 Cell Counts >= 200/mm3
NCT00002161
Registered record
- Registry ID
- NCT00002161
- Conditions
- HIV Infections
- Interventions
- Adefovir dipivoxil
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 400
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionAdefovir dipivoxilPhaseNot applicableRegistry statusCompleted