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AMR Drug RepurposingSmart Screeningresearch prototype

Protirelin

FDA-approved product (injectable, injection), marketed as Thypinone, Thyrel Trh.

Registered studies
15
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Protirelin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Protirelin. Its therapeutic class is shown instead.

WHO therapeutic group
Tests for thyreoidea function
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae33.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

15registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Protirelin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Protirelin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer

    NCT04868045 · start 2021-04-27

    Registered record
    Registry ID
    NCT04868045
    Conditions
    Thyroid Cancer
    Interventions
    Thyrotropin Releasing Hormone (TRH); levothyroxine; Hypothyroidism QOL questionnaire
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2021-04-27
    Completion
    2023-02-15
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Cancer
    InterventionThyrotropin Releasing Hormone (TRH); levothyroxine; Hypothyroidism QOL questionnaire
    PhasePhase 1
    Registry statusWithdrawn

  • Mechanistic Study of Subclinical Hypothyroidism In the Elderly

    NCT02399475 · start 2015-01-01

    Registered record
    Registry ID
    NCT02399475
    Conditions
    Subclinical Hypothyroidism
    Interventions
    Levothyroxine; Liothyronine; Thyrotropin-Releasing Hormone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01-01
    Completion
    2019-09-30
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubclinical Hypothyroidism
    InterventionLevothyroxine; Liothyronine; Thyrotropin-Releasing Hormone
    PhaseNot applicable
    Registry statusCompleted

  • A Confirmatory Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)

    NCT01970098 · start 2013-10-09

    Registered record
    Registry ID
    NCT01970098
    Conditions
    Spinocerebellar Degeneration
    Interventions
    KPS-0373, High dose; KPS-0373, Low dose; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-10-09
    Completion
    2015-01
    Enrolment
    374

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinocerebellar Degeneration
    InterventionKPS-0373, High dose; KPS-0373, Low dose; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3

    NCT00812149 · start 2008-12-17

    Registered record
    Registry ID
    NCT00812149
    Conditions
    Thyroid Disease; Healthy
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-12-17
    Completion
    2014-05-16
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Disease; Healthy
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of Synthetic Thyrotropin Releasing Hormone (TRH) as a Treatment for Cancer-related Fatigue

    NCT00790296 · start 2006-12

    Registered record
    Registry ID
    NCT00790296
    Conditions
    Cancer-related Fatigue
    Interventions
    Thyrotropin releasing hormone (TRH); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2006-12
    Completion
    2010-03
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCancer-related Fatigue
    InterventionThyrotropin releasing hormone (TRH); Placebo
    PhasePhase 2
    Registry statusTerminated

  • Thyroid and Glucose and Energy Metabolism

    NCT00106119 · start 2005-03

    Registered record
    Registry ID
    NCT00106119
    Conditions
    Thyroid Diseases
    Interventions
    Liothyronine and Levothyroxine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-03
    Completion
    2013-11
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Diseases
    InterventionLiothyronine and Levothyroxine
    PhasePhase 2
    Registry statusCompleted

  • Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities

    NCT00054756 · start 2003-02-07

    Registered record
    Registry ID
    NCT00054756
    Conditions
    Healthy; Pituitary Disease; Thyroid Disease
    Interventions
    TRH (Thyrotropin Releasing Hormone)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-02-07
    Completion
    2014-09-26
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Pituitary Disease; Thyroid Disease
    InterventionTRH (Thyrotropin Releasing Hormone)
    PhasePhase 2
    Registry statusCompleted

  • Study of Antenatal Thyrotropin-Releasing Hormone in Women in Premature Labor to Prevent Lung Disease in Preterm Infants

    NCT00004840 · start 1998-05

    Registered record
    Registry ID
    NCT00004840
    Conditions
    Respiratory Distress Syndrome
    Interventions
    thyrotropin-releasing hormone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1998-05
    Completion
    1998-06
    Enrolment
    996

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome
    Interventionthyrotropin-releasing hormone
    PhaseNot applicable
    Registry statusCompleted

  • Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery

    NCT00004778 · start 1993-08

    Registered record
    Registry ID
    NCT00004778
    Conditions
    Respiratory Distress Syndrome
    Interventions
    betamethasone; dexamethasone; thyrotropin-releasing hormone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1993-08
    Completion
    Not recorded
    Enrolment
    1,090

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome
    Interventionbetamethasone; dexamethasone; thyrotropin-releasing hormone
    PhasePhase 3
    Registry statusCompleted

  • Phase II Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)

    NCT00863538

    Registered record
    Registry ID
    NCT00863538
    Conditions
    Spinocerebellar Degeneration
    Interventions
    KPS-0373
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinocerebellar Degeneration
    InterventionKPS-0373
    PhasePhase 2
    Registry statusCompleted

  • A Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)

    NCT01004016

    Registered record
    Registry ID
    NCT01004016
    Conditions
    Spinocerebellar Degeneration
    Interventions
    KPS-0373; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinocerebellar Degeneration
    InterventionKPS-0373; Placebo
    PhasePhase 2
    Registry statusCompleted

  • A Phase II Double Blind Comparative Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)

    NCT01384435

    Registered record
    Registry ID
    NCT01384435
    Conditions
    SCD
    Interventions
    KPS-0373; KPS-0373; KPS-0373; KPS-0373; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSCD
    InterventionKPS-0373; KPS-0373; KPS-0373; KPS-0373 +1 more
    PhasePhase 2
    Registry statusCompleted

  • An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)

    NCT01970111

    Registered record
    Registry ID
    NCT01970111
    Conditions
    Spinocerebellar Degeneration
    Interventions
    KPS-0373, High dose; KPS-0373, Low dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinocerebellar Degeneration
    InterventionKPS-0373, High dose; KPS-0373, Low dose
    PhasePhase 3
    Registry statusCompleted

  • A Long-Term Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)

    NCT01970124

    Registered record
    Registry ID
    NCT01970124
    Conditions
    Spinocerebellar Degeneration
    Interventions
    KPS-0373, High dose; KPS-0373, Low dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinocerebellar Degeneration
    InterventionKPS-0373, High dose; KPS-0373, Low dose
    PhasePhase 3
    Registry statusCompleted

  • A 24-week Open-label Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)

    NCT01970137

    Registered record
    Registry ID
    NCT01970137
    Conditions
    Spinocerebellar Degeneration
    Interventions
    KPS-0373, High dose; KPS-0373, Low dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinocerebellar Degeneration
    InterventionKPS-0373, High dose; KPS-0373, Low dose
    PhasePhase 3
    Registry statusCompleted