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AMR Drug RepurposingSmart Screeningresearch prototype

Dicloxacillin Sodium

FDA-approved product (capsule, oral), marketed as Dicloxacillin Sodium, Dycill, Dynapen and 1 more.

Registered studies
17
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Dicloxacillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta-lactamase resistant penicillins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CF01

Repurposing investigation

Dicloxacillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA24.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli26.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae50.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis41.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

17registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Dicloxacillin Sodium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Dicloxacillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Staphylococcus Aureus and The Skin Microbiome During Flare And Resolution Of Atopic Dermatitis

    NCT05578482 · start 2022-10-24

    Registered record
    Registry ID
    NCT05578482
    Conditions
    Atopic Dermatitis; Atopic Dermatitis Eczema; Atopic Dermatitis Flare
    Interventions
    Dicloxacillin Oral Capsule; Elocon 0.1 % Topical Cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-10-24
    Completion
    2023-05
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtopic Dermatitis; Atopic Dermatitis Eczema; Atopic Dermatitis Flare
    InterventionDicloxacillin Oral Capsule; Elocon 0.1 % Topical Cream
    PhasePhase 4
    Registry statusUnknown

  • Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture

    NCT05530174 · start 2022-09-01

    Registered record
    Registry ID
    NCT05530174
    Conditions
    Fracture of Hip; Total Hip Arthroplasty; Prosthetic-joint Infection; Fracture Acetabular
    Interventions
    Antibiotic dosage practice
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2022-09-01
    Completion
    2025-04-01
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFracture of Hip; Total Hip Arthroplasty; Prosthetic-joint Infection; Fracture Acetabular
    InterventionAntibiotic dosage practice
    PhaseNot applicable
    Registry statusActive not recruiting

  • Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA

    NCT05530551 · start 2022-09-01

    Registered record
    Registry ID
    NCT05530551
    Conditions
    Osteoarthritis, Hip; Total Hip Arthroplasty; Prosthetic-joint Infection
    Interventions
    Antibiotic dosage practice
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-09-01
    Completion
    2025-09-01
    Enrolment
    20,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Hip; Total Hip Arthroplasty; Prosthetic-joint Infection
    InterventionAntibiotic dosage practice
    PhaseNot applicable
    Registry statusCompleted

  • Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis

    NCT05398679 · start 2022-08-17

    Registered record
    Registry ID
    NCT05398679
    Conditions
    Endocarditis Infective
    Interventions
    Cefaclor; Ciprofloxacin Tablets; Ciprofloxacin Injection; Clindamycin Oral Capsule; Clindamycin Injection; Dicloxacillin Oral Capsule; Dicloxacillin; Fusidic Acid Only Product in Oral Dose Form; Fusidic Acid Only Product in Parenteral Dose Form; Levofloxacin Oral Tablet; Levofloxacin Injection; Linezolid Oral Tablet; Linezolid Injectable Product; Moxifloxacin tablet; Moxifloxacin Injectable Product; Rifampicin Only Product in Oral Dose Form; Rifampicin Only Product in Parenteral Dose Form; Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim]; Sulfamethoxazole / Trimethoprim Injectable Product; Tedizolid Oral Tablet; Tedizolid Injection; Amoxicillin Capsules; Amoxicillin; Cefaclor Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2022-08-17
    Completion
    2027-12-30
    Enrolment
    360

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndocarditis Infective
    InterventionCefaclor; Ciprofloxacin Tablets; Ciprofloxacin Injection; Clindamycin Oral Capsule +20 more
    PhasePhase 4
    Registry statusRecruiting

  • Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)

    NCT05156437 · start 2022-03-16

    Registered record
    Registry ID
    NCT05156437
    Conditions
    Endocarditis
    Interventions
    Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin; Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2022-03-16
    Completion
    2024-10-31
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndocarditis
    InterventionAmoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin; Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline
    PhasePhase 4
    Registry statusTerminated

  • The Effect of Dicloxacillin on Oral Absorption of Drugs

    NCT05073627 · start 2022-02-07

    Registered record
    Registry ID
    NCT05073627
    Conditions
    Healthy Volunteers; Drug-drug Interaction
    Interventions
    Dicloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2022-02-07
    Completion
    2022-06-22
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers; Drug-drug Interaction
    InterventionDicloxacillin
    PhasePhase 1
    Registry statusCompleted

  • Oral-only Antibiotics for Bone and Joint Infections in Children

    NCT04563325 · start 2020-09-15

    Registered record
    Registry ID
    NCT04563325
    Conditions
    Osteomyelitis; Septic Arthritis; Bone Infection; Joint Infection; Bone and Joint Infection
    Interventions
    Oral co-amoxiclav or oral dicloxacillin only; IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-09-15
    Completion
    2024-08-05
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis; Septic Arthritis; Bone Infection; Joint Infection +1 more
    InterventionOral co-amoxiclav or oral dicloxacillin only; IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
    PhasePhase 4
    Registry statusCompleted

  • Intramedullary Nailing vs External Ring Fixation for the Treatment of Tibial Shaft Fractures

    NCT03945669 · start 2019-11-01

    Registered record
    Registry ID
    NCT03945669
    Conditions
    Tibial Shaft Fracture
    Interventions
    Intramedullary Nailing; External Ring fixation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-11-01
    Completion
    2024-06-24
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTibial Shaft Fracture
    InterventionIntramedullary Nailing; External Ring fixation
    PhaseNot applicable
    Registry statusCompleted

  • Individualized Treatment of Acute Achilles Tendon Rupture

    NCT03525964 · start 2018-10-02

    Registered record
    Registry ID
    NCT03525964
    Conditions
    Achilles Tendon Rupture
    Interventions
    Individualized treatment of Acute Achilles tendon rupture.; Non-operative treatment; Operative treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-10-02
    Completion
    2024-09-24
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAchilles Tendon Rupture
    InterventionIndividualized treatment of Acute Achilles tendon rupture.; Non-operative treatment; Operative treatment
    PhaseNot applicable
    Registry statusCompleted

  • Achilles Tendon Elongation and Gait Pattern After Rupture.

    NCT03543943 · start 2018-06-04

    Registered record
    Registry ID
    NCT03543943
    Conditions
    Achilles Tendon Rupture
    Interventions
    Individualized treatment of Acute Achilles tendon rupture.; Non-operative treatment; Operative treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-06-04
    Completion
    2020-12-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAchilles Tendon Rupture
    InterventionIndividualized treatment of Acute Achilles tendon rupture.; Non-operative treatment; Operative treatment
    PhaseNot applicable
    Registry statusCompleted

  • Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia

    NCT03108690 · start 2017-10-01

    Registered record
    Registry ID
    NCT03108690
    Conditions
    Bacteremia
    Interventions
    Continuous infusion of beta-lactam antibiotics .; Therapeutic drug monitoring of beta-lactam antibiotics.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-10-01
    Completion
    2023-03-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionContinuous infusion of beta-lactam antibiotics .; Therapeutic drug monitoring of beta-lactam antibiotics.
    PhasePhase 4
    Registry statusWithdrawn

  • Dicloxacillin: Clinical Relevance of Drug-drug Interactions by Induction of Drug Metabolism.

    NCT02983890 · start 2016-10-06

    Registered record
    Registry ID
    NCT02983890
    Conditions
    Healthy
    Interventions
    Dicloxacillin; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-10-06
    Completion
    2017-10-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionDicloxacillin; Placebos
    PhasePhase 1
    Registry statusCompleted

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • Antibiotic Concentrations Among Critically Ill Patients

    NCT01543334 · start 2012-03

    Registered record
    Registry ID
    NCT01543334
    Conditions
    Administration of Antibiotics in Intensive Care Units
    Interventions
    Blood sampling
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-03
    Completion
    2012-04-01
    Enrolment
    98

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdministration of Antibiotics in Intensive Care Units
    InterventionBlood sampling
    PhaseNot recorded
    Registry statusCompleted

  • Determinants of Warfarin Metabolism

    NCT00162474 · start 2003-09

    Registered record
    Registry ID
    NCT00162474
    Conditions
    Healthy
    Interventions
    Warfarin; Phenytoin; Losartan & Hydrochlorothiazide; Flurbiprofen; Siponimod; Dicloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2003-09
    Completion
    2030-12
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionWarfarin; Phenytoin; Losartan & Hydrochlorothiazide; Flurbiprofen +2 more
    PhaseNot applicable
    Registry statusRecruiting