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AMR Drug RepurposingSmart Screeningresearch prototype

Atracurium Besylate

FDA-approved product (injectable, injection), marketed as Atracurium Besylate, Atracurium Besylate Preservative Free, Tracrium and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Atracurium Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Neuromuscular Blockade

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Atracurium Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Atracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Comparison of Anaesthesia Requirement for Ventilation With Endotracheal Tube Versus Proseal Laryngeal Mask Airway

    NCT03812718 · start 2019-03-04

    Registered record
    Registry ID
    NCT03812718
    Conditions
    Cholelithiases; Cholecystolithiasis
    Interventions
    Endotracheal tube (ETT); ProSeal Laryngeal Mask Airway (PLMA)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2019-03-04
    Completion
    2026-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholelithiases; Cholecystolithiasis
    InterventionEndotracheal tube (ETT); ProSeal Laryngeal Mask Airway (PLMA)
    PhaseNot applicable
    Registry statusRecruiting

  • Postoperative Analgesia of Quadratus Lumborum Block Versus Epidural Block After Major Abdominal Surgeries

    NCT04541732 · start 2019-01-01

    Registered record
    Registry ID
    NCT04541732
    Conditions
    Elective Major Abdominal Surgery
    Interventions
    Thoracic epidural block; Ultrasound-guided bilateral quadratus lumborum block; Induction of general anaesthesia with propofol; Muscle Relaxant; Maintenance of general anaesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-01-01
    Completion
    2019-05-06
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionElective Major Abdominal Surgery
    InterventionThoracic epidural block; Ultrasound-guided bilateral quadratus lumborum block; Induction of general anaesthesia with propofol; Muscle Relaxant +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of CLSB With Sedation Versus General Endotracheal Anesthesia on Postoperative Outcomes in Elderly Patients Undergoing Hip Fracture Surgery

    NCT03318133 · start 2018-12-04

    Registered record
    Registry ID
    NCT03318133
    Conditions
    Anesthesia Morbidity; Anesthesia; Adverse Effect
    Interventions
    anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-12-04
    Completion
    2023-12-31
    Enrolment
    1,086

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia Morbidity; Anesthesia; Adverse Effect
    Interventionanesthesia
    PhaseNot applicable
    Registry statusUnknown

  • ED50 of Cis-atracurium for Laryngeal Mask Incubation in General Anesthesia

    NCT03668262 · start 2018-09-15

    Registered record
    Registry ID
    NCT03668262
    Conditions
    Urologic Diseases
    Interventions
    Cis-atracurium
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-09-15
    Completion
    2019-01-30
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrologic Diseases
    InterventionCis-atracurium
    PhaseNot recorded
    Registry statusCompleted

  • Quadratus Lumborum Block Using Loss-of-resistance Versus Ultrasound-guided Technique

    NCT03328481 · start 2018-05-28

    Registered record
    Registry ID
    NCT03328481
    Conditions
    Lower Abdominal Surgery; Quadratus Lumborum Block
    Interventions
    Loss-of-resistance Quadratus lumborum block; Ultrasound-guided Quadratus lumborum block; General anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-05-28
    Completion
    2018-09-20
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLower Abdominal Surgery; Quadratus Lumborum Block
    InterventionLoss-of-resistance Quadratus lumborum block; Ultrasound-guided Quadratus lumborum block; General anesthesia
    PhaseNot applicable
    Registry statusUnknown

  • Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS

    NCT03376854 · start 2018-05-01

    Registered record
    Registry ID
    NCT03376854
    Conditions
    Respiratory Distress Syndrome, Adult; Sars-CoV2
    Interventions
    Hypothermia; Neuromuscular Blocking Agents; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2018-05-01
    Completion
    2021-04-27
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome, Adult; Sars-CoV2
    InterventionHypothermia; Neuromuscular Blocking Agents; Standard of Care
    PhasePhase 2
    Registry statusWithdrawn

  • Analgesic Efficacy of Duloxetine in Patients Undergoing Lumbar Discectomy

    NCT03549026 · start 2018-01-05

    Registered record
    Registry ID
    NCT03549026
    Conditions
    Acute Pain
    Interventions
    Duloxetine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-01-05
    Completion
    2019-12-25
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    InterventionDuloxetine; placebo
    PhaseNot applicable
    Registry statusUnknown

  • The Immune Modulation of Bilateral Paravertebral Block and Propofol in Spine Surgery.

    NCT03437213 · start 2018-01-01

    Registered record
    Registry ID
    NCT03437213
    Conditions
    Immune Suppression
    Interventions
    Total intravenous anesthesia group; Total intravenous plus block group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-01-01
    Completion
    2020-09-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImmune Suppression
    InterventionTotal intravenous anesthesia group; Total intravenous plus block group
    PhaseNot applicable
    Registry statusCompleted

  • Evaluation of Atracurium-vecuronium Combination in Laparosocpic Surgery

    NCT03371953 · start 2017-12-20

    Registered record
    Registry ID
    NCT03371953
    Conditions
    Patients Undergoing Laparoscopic Surgery
    Interventions
    Vecuronium; Atracurium; Vecuronium + Atracurium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-12-20
    Completion
    2018-10-25
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients Undergoing Laparoscopic Surgery
    InterventionVecuronium; Atracurium; Vecuronium + Atracurium
    PhasePhase 4
    Registry statusUnknown

  • Effect of Cervical Epidural Analgesia on the Occurrence of Pharyngocutaneous Fistula

    NCT02870556 · start 2016-12-20

    Registered record
    Registry ID
    NCT02870556
    Conditions
    Cutaneous Fistula; Laryngectomy
    Interventions
    cervical epidural analgesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-12-20
    Completion
    2019-12-10
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCutaneous Fistula; Laryngectomy
    Interventioncervical epidural analgesia
    PhaseNot applicable
    Registry statusUnknown

  • Dexmedetomidine and Desflurane Consumption

    NCT02652312 · start 2016-02

    Registered record
    Registry ID
    NCT02652312
    Conditions
    Anesthesia
    Interventions
    Dexmedetomidine; Placebo; Ondansetron; fentanyl; propofol; Atracurium; diclofenac sodium; desflurane
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-02
    Completion
    2016-10
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia
    InterventionDexmedetomidine; Placebo; Ondansetron; fentanyl +4 more
    PhaseNot applicable
    Registry statusCompleted

  • Transversus Abdominis Plane Block for Laparoscopic Appendicectomy in Children

    NCT02505841 · start 2015-05

    Registered record
    Registry ID
    NCT02505841
    Conditions
    Laparoscopic Appendectomy
    Interventions
    TAP block with Ropivacaine; Curare
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-05
    Completion
    2017-06
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic Appendectomy
    InterventionTAP block with Ropivacaine; Curare
    PhaseNot applicable
    Registry statusUnknown

  • Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass

    NCT02840006 · start 2014-09

    Registered record
    Registry ID
    NCT02840006
    Conditions
    Myocardial Revascularization; Spinal Anesthesia; Postoperative Care; Fentanyl
    Interventions
    General anesthesia only; General anesthesia and Spinal anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-09
    Completion
    Not recorded
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Revascularization; Spinal Anesthesia; Postoperative Care; Fentanyl
    InterventionGeneral anesthesia only; General anesthesia and Spinal anesthesia
    PhasePhase 4
    Registry statusCompleted

  • The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy

    NCT02109133 · start 2014-05

    Registered record
    Registry ID
    NCT02109133
    Conditions
    Robot-Assisted Laparoscopic Radical Prostatectomy
    Interventions
    deep neuromuscular blockade; moderate neuromuscular blockade; Rocuronium; Sugammadex; Atracurium; Neostigmine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-05
    Completion
    2014-12
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRobot-Assisted Laparoscopic Radical Prostatectomy
    Interventiondeep neuromuscular blockade; moderate neuromuscular blockade; Rocuronium; Sugammadex +2 more
    PhaseNot applicable
    Registry statusCompleted

  • A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial

    NCT01870011 · start 2013-12

    Registered record
    Registry ID
    NCT01870011
    Conditions
    End Stage Renal Disease
    Interventions
    Desflurane balanced anesthesia; Propofol total intravenous anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-12
    Completion
    2014-11
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnd Stage Renal Disease
    InterventionDesflurane balanced anesthesia; Propofol total intravenous anesthesia
    PhasePhase 4
    Registry statusCompleted