Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- SelpercatinibExisting use: Cancer, Medullary thyroid gland carcinoma, Neoplasm and 4 more59.0% AI-predicted activityagainst M. tuberculosis42 registered studies
- SulindacExisting use: Osteoarthritis, Rheumatic disease, Rheumatoid arthritis and 1 more59.0% AI-predicted activityagainst M. tuberculosis40 registered studies
- SumatriptanExisting use: Migraine disorder59.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- SuvorexantExisting use: Insomnia59.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- TravoprostExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma59.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Sunitinib MalateExisting use: Cancer, Clear cell renal carcinoma, Gastrointestinal stromal tumor and 6 more59.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Delavirdine MesylateExisting use: Viral disease58.9% AI-predicted activityagainst M. tuberculosis27 registered studies
- Desmopressin AcetateExisting use: Central diabetes insipidus, Diabetes insipidus, Enuresis and 5 more58.9% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Terlipressin AcetateExisting use: Hepatorenal syndrome, Kidney failure, Renal insufficiency58.9% AI-predicted activityagainst M. tuberculosis7 registered studies
- Amlodipine MaleateExisting use: Angina pectoris, Cardiovascular disease, Congestive heart failure and 11 more58.8% AI-predicted activityagainst M. tuberculosis2 registered studies
- Indocyanine GreenExisting use: Other diagnostic agents58.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Levamlodipine MaleateExisting use: Cardiovascular disease, Hypertension58.8% AI-predicted activityagainst M. tuberculosis4 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.